Glutaminolysis and autophagy in cancer

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mTOR Signaling in Growth Control and Disease

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

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Autophagy and the Integrated Stress Response

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The Role of Atg Proteins in Autophagosome Formation

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Defining the role of mTOR in cancer

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The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

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Self-consumption: the interplay of autophagy and apoptosis

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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

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Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

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Autophagy and Metabolism

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Mammalian autophagy: core molecular machinery and signaling regulation

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Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

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Glutamine addiction: a new therapeutic target in cancer

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Deconvoluting the context-dependent role for autophagy in cancer

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Termination of autophagy and reformation of lysosomes regulated by mTOR

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Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

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Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks

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Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

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Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

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HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia

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Autophagy-deficient mice develop multiple liver tumors

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MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

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Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

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Emerging regulation and functions of autophagy

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Functional and physical interaction between Bcl‐XL and a BH3‐like domain in Beclin‐1

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Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer

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Making new contacts: the mTOR network in metabolism and signalling crosstalk

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Targeting cellular metabolism to improve cancer therapeutics

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Autophagy—a key player in cellular and body metabolism

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Principles and Current Strategies for Targeting Autophagy for Cancer Treatment

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Amino acid signalling upstream of mTOR

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Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

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AMP-activated Protein Kinase Suppresses Protein Synthesis in Rat Skeletal Muscle through Down-regulated Mammalian Target of Rapamycin (mTOR) Signaling

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Autophagy as a target for anticancer therapy

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Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

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Regulation of mTORC1 by amino acids

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Glutaminolysis Activates Rag-mTORC1 Signaling

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The mitochondrial transporter family (SLC25): physiological and pathological implications

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Autophagy regulation by nutrient signaling

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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

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Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

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Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes

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The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

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Balancing Akt with S6K

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p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

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Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling

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Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of Autophagy

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