The DOI matches its Crossref record; 54 of the 55 references it cites were found in a registry or an index.
Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure
Open accessAbstract
-induced mitochondrial permeability transition pore opening. Of interest, disruption of autophagic flux was sufficient to decrease cardiac mitochondrial function in sham-treated animals and increase cardiomyocyte toxicity upon mitochondrial stress. Importantly, 8 wk of exercise training, starting 4 wk after myocardial infarction at a time when autophagy and mitochondrial oxidative capacity were already impaired, improved cardiac autophagic flux. These changes were followed by reduced mitochondrial number:size ratio, increased mitochondrial bioenergetics and better cardiac function. Moreover, exercise training increased cardiac mitochondrial number, size and oxidative capacity without affecting autophagic flux in sham-treated animals. Further supporting an autophagy mechanism for exercise-induced improvements of mitochondrial bioenergetics in heart failure, acute in vivo inhibition of autophagic flux was sufficient to mitigate the increased mitochondrial oxidative capacity triggered by exercise in failing hearts. Collectively, our findings uncover the potential contribution of exercise in restoring cardiac autophagy flux in heart failure, which is associated with better mitochondrial quality control, bioenergetics and cardiac function.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Moreover, exercise is the best non-pharmacological strategy to reactivate mitophagy, which reduces the accumulation of ROS and thus, improves mitochondrial health and delays the loss of muscle mass that accompanies various pathologies, including aging sarcopenia, heart failure and neurogenic myopathy [224, 238–240].”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [239]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.019 · Cited by 12,536
Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., de Ferranti, S., Després, J.-P., Fullerton, H. J., Howard, V. J., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000152 · Cited by 5,797
Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M. L., Konstam, M. A., MANCINI, D. M., Michl, K., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.192065 · Cited by 3,739
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability
Gomes, L. C., Benedetto, G. D., & Scorrano, L. (2011) · Nature Cell Biology · doi:10.1038/ncb2220 · Cited by 1,735
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress
Nakai, A., Yamaguchi, O., Takeda, T., Higuchi, Y., Hikoso, S., Taniike, M., Omiya, S., Mizote, I., Matsumura, Y., Asahi, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1574 · Cited by 1,520
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
Tanaka, A., Cleland, M. M., Xu, S., Narendra, D. P., Suen, D.-F., Karbowski, M., & Youle, R. J. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201007013 · Cited by 1,369
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure
Liesa, M., & Shirihai, O. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.002 · Cited by 1,341
PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria
Chen, Y., & Dorn, G. W. (2013) · Science · doi:10.1126/science.1231031 · Cited by 1,323
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
Oka, T., Hikoso, S., Yamaguchi, O., Taneike, M., Takeda, T., Tamai, T., Oyabu, J., Murakawa, T., Nakayama, H., Nishida, K., et al. (2012) · Nature · doi:10.1038/nature10992 · Cited by 1,201
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
He, C., Bassik, M. C., Moresi, V., Sun, K., Wei, Y., Zou, Z., An, Z., Loh, J., Fisher, J., Sun, Q., et al. (2012) · Nature · doi:10.1038/nature10758 · Cited by 1,136
Cited by
Sorted by citations
Items 101–145 of 145
Nijholt, K. T., Sánchez-Aguilera, P., Mahmoud, B., Gerding, A., Wolters, J. C., Wolters, A. H. G., Giepmans, B. N. G., Silljé, H. H. W., de Boer, R. A., Bakker, B. M., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-45961-z · Cited by 5
Visco, V., Forte, M., Giallauria, F., D’Ambrosio, L., Piccoli, M., Schiattarella, G. G., Mancusi, C., Salerno, N., Cesaro, A., Perrone, M. A., et al. (2025) · International Journal of Cardiology · doi:10.1016/j.ijcard.2025.133166 · Cited by 4
Ma, Z., Cen, Y., Xun, W., Mou, C., Yu, J., Hu, Y., Liu, C., Sun, J., Bi, R., Qiu, Y., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-95637-z · Cited by 4
Zhang, X., Song, Y., Mai, H., Feng, W., Sun, J., Zhao, Z., Zhou, S., Zhao, A. Z., Mu, Y., & Li, F. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117366 · Cited by 4
Exercise-Mediated Autophagy in Cardiovascular Diseases
Jia, S., Zhang, H., Liang, J., Zhang, Y., Guo, Y., & Chen, N. (2021) · Springer eBooks · doi:10.1007/978-981-16-4525-9_9 · Cited by 4
The Role and Underlying Mechanisms of Exercise in Heart Failure
Zhang, C.-Y., Li, K.-L., Zhao, X., Zhang, Z., Yin, A.-W., & Wang, R. (2024) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2508285 · Cited by 4
Dhanabalan, K., Huisamen, B., & Lochner, A. (2020) · Cardiovascular journal of South Africa/Cardiovascular journal of Southern Africa · doi:10.5830/cvja-2019-067 · Cited by 4
Editorial: Mitochondrial Metabolism in Ischemic Heart Disease
Yang, L., Wang, S., Wu, J., Ma, L., Li, Y., & Tang, H. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.961580 · Cited by 4
Reduce, Reuse, Recycle, Run ! : 4 Rs to improve cardiac health in advanced age
Cho, J. M., Ghosh, R., Mookherjee, S., Boudina, S., & Symons, J. D. (2022) · Aging · doi:10.18632/aging.204415 · Cited by 3
Insights from Exercise-induced Cardioprotection-from Clinical Application to Basic Research
Jiang, H., Zhang, B., Jia, D., Yang, W., Sun, A., & Ge, J. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191008102047 · Cited by 3
Huang, S., Chen, Z., Li, H.-M., Zheng, L., Zhou, Z., Peng, X., & Tang, C. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1642389 · Cited by 2
Qin, S., Ma, Y., Ren, W., Xi, Y., Li, H., Bo, W., & Tian, Z. (2026) · The FASEB Journal · doi:10.1096/fj.202500863rrrr · Cited by 2
The Thyroid-Oxidative Stress Axis in Heart Failure
Gaggini, M., Traghella, I., & Vassalle, C. (2020) · Springer eBooks · doi:10.1007/978-3-030-36871-5_14 · Cited by 2
Biomarkers in Hypertension and Hypertension-related Disorders
Ribeiro, P. D. C., de Oliveira, L. F., Filho, D. M., Parreira, R. C., Vieira, M. S., Marques, B. L., Freitas, E. M. D. M., da Silva, W. N., Santiago, H. C., Birbrair, A., et al. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220921113403 · Cited by 2
Gouveia, M., Schmidt, C., Basilio, P. G., Aveiro, S. S., Domingues, P. M., Xia, K., Colón, W., Vitorino, R. M. P., Ferreira, R. M., Santos, M., et al. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04884-z · Cited by 2
Pyruvate dehydrogenase alleviates macrophage autophagy in Hcy-induced ApoE–/– mice
Liu, Q., Feng, L., Hu, S., Ding, N., Ma, F., Hao, Y., Li, G., Xiong, J., Zhang, H., & Jiang, Y. (2025) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025021 · Cited by 2
Laine-Menéndez, S., la Torre, M. F.-D., Fiuza‐Luces, C., Delmiro, A., Arenas, J., Martín, M. A., Boya, P., Lucía, A., & Morán, M. (2022) · Antioxidants · doi:10.3390/antiox11030510 · Cited by 2
Exercise Therapy for Patients with Heart Failure: Focusing on the Pathophysiology of Skeletal Muscle
Morotomi, N., Sakuma, K., & Sakai, K. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.97291 · Cited by 1
The Role of Autophagy in Heart Disease
Mohiuddin, O., Abraham, S., Zhang, H., & Ruiz‐Velasco, A. (2024) · International Journal of Drug Discovery and Pharmacology · doi:10.53941/ijddp.2024.100021 · Cited by 1
Fu, Y., Jin, L., Zhang, Y., Gong, H., Zhang, Y., Liu, P., Jiang, T., Qin, X., & Zheng, Q. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.116024 · Cited by 1
FECHAMENTO DO FORAME OVAL PATENTE: UMA REVISÃO DE LITERATURA
Silva, A. E. D., Volpato, L. B., da Silva, W. C. F. N., Bonini, J. S., Bahr, A. C., Somensi, L. B., & de Gregório, E. (2023) · Revista Contemporânea · doi:10.56083/rcv3n6-029 · Cited by 1
A Subject Review on Application of Analytical Chemistry in the Mitochondrial Medicine
S., J. J. M. (2024) · International Journal of Pharmaceutical Sciences and Nanotechnology · doi:10.37285/ijpsn.2024.17.3.10 · Cited by 1
Mori, M. A. (2021) · Biophysical Reviews · doi:10.1007/s12551-021-00888-5 · Cited by 1
Pelozin, B. R. D. A., Rodrigues, L. F., de Oliveira, E. M., & Fernandes, T. M. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.100625 · Cited by 1
Abreu, P., & Kowaltowski, A. J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/845438
Self-citationObesity-induced hepatic changes during pregnancy
Grilo, L. F. (2019) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Effects of physiologic inputs on autophagy
Eisenberg, T., Abdellatif, M., Ljubojević-Holzer, S., & Sedej, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822003-0.00001-2
Prospective Advances in Exercise-Induced Autophagy on Health
Liang, J., Kirberger, M., & Chen, N. (2021) · Springer eBooks · doi:10.1007/978-981-16-4525-9_11
Exercise preserves fitness capacity during aging through AMPK and mitochondrial dynamicsPreprint
Campos, J. C., Bozi, L. H. M., Traa, A., van der Bliek, A. M., Raamsdonk, J. M. V., Blackwell, T. K., & Ferreira, J. C. B. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.20.496837
Self-citationLashgari, A. A., Azarbayjani, M. A., Peeri, M., & Nasehi, M. (2022) · فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران · doi:10.52547/iau.32.3.281
Plasticidade mitocondrial na doença de Chagas
Ribeiro, M. A. C. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2022.tde-21082023-154733
Prospects for the Use of Cell Cultures in Modeling Myocardial Diseases: Hypertrophic Cardiomyopathy
Klass, A. L., Shadrina, M. I., Slominsky, P. A., & Filatova, E. V. (2024) · Cell and Tissue Biology · doi:10.1134/s1990519x24700305
Aging-related comorbidities, life-style interventions and therapeutic strategies in heart failure
Phan, N. N., & Yunus, F.-U.-N. (2025) · doi:10.32948/ajsep.2025.03.20
Xu, L., Chen, C., Wang, K., & Wang, T. (2025) · BMC Cardiovascular Disorders · doi:10.1186/s12872-025-05442-9
Tagashira, H., Abe, F., Yoshizaki, M., & Numata, T. (2025) · Cureus · doi:10.7759/cureus.99981
Liu, Z., Su, W., Li, X., Guo, L., & Gao, W. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.02.029
Rôle du stress oxydant dans le remodelage cardiaque induit par l'obésité
Masri, Y. E. (2024) · theses.fr (ABES) · doi:10.70675/8079719dzd619z4251z9b8fz80e07d39e6c9
Wei, T., Zhou, C., You, J., Sun, Y., & Zhang, Q. (2026) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-026-10781-9
Beyond autophagic flux: selective autophagy adaptors and cargo prioritization in cardiac disease
Espitia-Corredor, J., Olivares-Silva, F., Alanis, C., Deng, Y., & Wang, Z. V. (2026) · Cardiology Plus · doi:10.1097/cp9.0000000000000161
Exploring the role of CaMKII in exercise-induced cardioprotection
Xu, Y., Liu, Z., & Li, X. (2026) · Human Cell · doi:10.1007/s13577-026-01425-w
Yin, Y., & Li, Z. (2026) · Aging Cell · doi:10.1111/acel.70729
Abbasi, A., Vieira, R. P., & Lopes, F. D. T. Q. S. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1870091
Kao, S., Yousaf, F., Ishaq, S., Shah, I. A., Wu, B.-T., & Lee, S.-D. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.116070
Metadata
- Authors
- Campos, J. C., Queliconi, B. B., Bozi, L. H. M., Bechara, L. R. G., Dourado, P. M. M., Andres, A. M., Jannig, P. R., Gomes, K. M. S., Zambelli, V. O., Rocha-Resende, C., Guatimosim, S., Brum, P. C., Mochly-Rosen, D., Gottlieb, R. A., Kowaltowski, A. J., & Ferreira, J. C. B.
- Affiliations
- Cedars-Sinai Medical Center (US)
- Universidade de São Paulo (BR)
- Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
- Instituto Butantan (BR)
- Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil
- School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil
- Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA
- Corresponding author
- Ferreira, Julio C. B.
- ORCID
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2017-08-03
- Volume
- 13
- Issue
- 8
- Pages
- 1304-1317
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- PMC
- PMC5584854
- OpenAlex
- W2624424641
- Cited by
- 146
- References
- 55
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 12 · 2023: 15 · 2022: 25 · 2021: 21 · 2020: 21 · 2019: 15 · 2018: 10 · 2017: 3
- FWCI
- 10.46
- Type
- journal article
- Language
- en
- Update notices
- correction (2024-03-21)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Autophagy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Institute on Alcohol Abuse and Alcoholism (R37AA011147)
- National Heart, Lung, and Blood Institute (R01HL052141, P01HL112730, R01HL132075)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- exercise training, autophagic flux, mitochondrial quality control, heart failure, myocardial infarction, mitochondrial permeability transition pore, mitochondrial bioenergetics, cardiomyocyte toxicity, mitochondrial oxidative capacity, cardiac function
- MeSH terms
- Animals, Autophagy, Cell Line, Cell Survival, Heart Failure, Male, Mitochondria, Physical Conditioning, Animal, Down-Regulation, Rats, Wistar, Mice, Mitochondrial Dynamics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
