Cited by 1,341Mitochondrial Function and PathologyAutophagy in Disease and TherapyAdipose Tissue and Metabolism

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

Open access
Liesa, Marc, Shirihai, Orian S.·2013·Cell Metabolism

Abstract

Mitochondrial fusion, fission, and mitophagy form an essential axis of mitochondrial quality control. However, quality control might not be the only task carried out by mitochondrial dynamics. Recent studies link mitochondrial dynamics to the balance between energy demand and nutrient supply, suggesting changes in mitochondrial architecture as a mechanism for bioenergetic adaptation to metabolic demands. By favoring either connected or fragmented architectures, mitochondrial dynamics regulates bioenergetic efficiency and energy expenditure. Placement of bioenergetic adaptation and quality control as competing tasks of mitochondrial dynamics might provide a new mechanism, linking excess nutrient environment to progressive mitochondrial dysfunction, common to age-related diseases.

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Registry

Crossref · 10.1016/j.cmet.2013.03.002

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115 of 115 references verified0 citation errors · 0 not checkable

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  • Mitochondrial mass is dynamic, and individual organelles can fuse with or shed from the network to meet the metabolic requirements of the cell.

    “The mitochondrial mass is dynamic; individual organelles can fuse or shed from the network to address the metabolic requirements of the cell97–99”

    From The role of mitochondria in rheumatic diseases (2022) · cites this paper as [97]

  • Mitochondrial architectural changes might offer a new molecular mechanism to connect nutrient availability to bioenergetic adaptations.

    “Thus, mitochondrial architectural changes might offer a new molecular mechanism to connect nutrient availability to bioenergetic adaptations (Liesa & Shirihai, 2013).”

    From Mitochondrial response to nutrient availability and its role in metabolic disease (2014) · cites this paper as Liesa & Shirihai, 2013

  • Under nutrient scarcity, mitochondrial fusion is typically observed.

    “Under these circumstances, mitochondrial fusion is typically observed (Liesa & Shirihai, 2013) (Fig 2A).”

    From Mitochondrial response to nutrient availability and its role in metabolic disease (2014) · cites this paper as Liesa & Shirihai, 2013

  • Mitochondrial fission is induced within minutes after lipid overload in INS-1 cells.

    “Along with this fusion deficiency, mitochondrial fission is induced within minutes after a lipid overload in INS-1 cells (Molina et al, 2009; Liesa & Shirihai, 2013) (Fig 3A).”

    From Mitochondrial response to nutrient availability and its role in metabolic disease (2014) · cites this paper as Liesa & Shirihai, 2013

  • Mitochondrial fission events promoted mitochondrial uncoupled respiration.

    “These mitochondrial fission events promoted mitochondrial uncoupled respiration (Liesa & Shirihai, 2013; Wikstrom et al, 2014).”

    From Mitochondrial response to nutrient availability and its role in metabolic disease (2014) · cites this paper as Liesa & Shirihai, 2013

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  1. Nicholls DG Ferguson SJ 2002 Bioenergetics 3 Academic Press

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Authors
Liesa, M., & Shirihai, O. S.
Affiliations
Boston University (US)
Corresponding author
Shirihai, Orian S.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2013-04
Volume
17
Issue
4
Pages
491-506
ISSN
1550-4131 (ISSN-L)
OpenAlex
W2019455536
Cited by
1,341
References
115
Citations by year
2026: 71 · 2025: 110 · 2024: 135 · 2023: 115 · 2022: 107 · 2021: 143 · 2020: 142 · 2019: 100 · 2018: 117 · 2017: 82 · 2016: 79 · 2015: 70 · 2014: 52 · 2013: 17
FWCI
6.84
Type
journal article
Language
en
Open access
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Heart, Lung, and Blood Institute (R01HL071629)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK035914, P30DK046200, R01 DK35914, R01 DK56690, R01DK074778, R01DK056690)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
mitochondrial dynamics, mitochondrial fusion, mitochondrial fission, mitophagy, mitochondrial quality control, nutrient utilization, energy expenditure, mitochondrial architecture, mitochondrial dysfunction, age-related diseases
MeSH terms
Adenosine Triphosphate, Aging, Animals, Adipose Tissue, Brown, Diabetes Mellitus, Type 2, Energy Metabolism, Humans, Mitochondria, Obesity, Muscle, Skeletal, Insulin-Secreting Cells, Mitochondrial Dynamics

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