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Thyroid hormone (T 3 ) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy
Open accessAbstract
The thyroid hormone triiodothyronine (T3) activates thermogenesis by uncoupling electron transport from ATP synthesis in brown adipose tissue (BAT) mitochondria. Although T3 can induce thermogenesis by sympathetic innervation, little is known about its cell autonomous effects on BAT mitochondria. We thus examined effects of T3 on mitochondrial activity, autophagy, and metabolism in primary brown adipocytes and BAT and found that T3 increased fatty acid oxidation and mitochondrial respiration as well as autophagic flux, mitophagy, and mitochondrial biogenesis. Interestingly, there was no significant induction of intracellular reactive oxygen species (ROS) despite high mitochondrial respiration and UCP1 induction by T3. However, when cells were treated with Atg5 siRNA to block autophagy, induction of mitochondrial respiration by T3 decreased, and was accompanied by ROS accumulation, demonstrating a critical role for autophagic mitochondrial turnover. We next generated an Atg5 conditional knockout mouse model (Atg5 cKO) by injecting Ucp1 promoter-driven Cre-expressing adenovirus into Atg5Flox/Flox mice to examine effects of BAT-specific autophagy on thermogenesis in vivo. Hyperthyroid Atg5 cKO mice exhibited lower body temperature than hyperthyroid or euthyroid control mice. Metabolomic analysis showed that T3 increased short and long chain acylcarnitines in BAT, consistent with increased β-oxidation. T3 also decreased amino acid levels, and in conjunction with SIRT1 activation, decreased MTOR activity to stimulate autophagy. In summary, T3 has direct effects on mitochondrial autophagy, activity, and turnover in BAT that are essential for thermogenesis. Stimulation of BAT activity by thyroid hormone or its analogs may represent a potential therapeutic strategy for obesity and metabolic diseases.Abbreviations: ACACA: acetyl-Coenzyme A carboxylase alpha; AMPK: AMP-activated protein kinase; Acsl1: acyl-CoA synthetase long-chain family member 1; ATG5: autophagy related 5; ATG7: autophagy related 7; ATP: adenosine triphosphate; BAT: brown adipose tissue; cKO: conditional knockout; COX4I1: cytochrome c oxidase subunit 4I1; Cpt1b: carnitine palmitoyltransferase 1b, muscle; CQ: chloroquine; DAPI: 4ʹ,6-diamidino-2-phenylindole; DIO2: deiodinase, iodothyronine, type 2; DMEM: Dulbecco’s modified Eagle’s medium; EIF4EBP1: eukaryotic translation initiation factor 4E binding protein 1; Fabp4: fatty acid binding protein 4, adipocyte; FBS: fetal bovine serum; FCCP: carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone; FGF: fibroblast growth factor; FOXO1: forkhead box O1; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; Gpx1: glutathione peroxidase 1; Lipe: lipase, hormone sensitive; MAP1LC3B: microtubule-associated protein 1 light chain 3; mRNA: messenger RNA; MTORC1: mechanistic target of rapamycin kinase complex 1; NAD: nicotinamide adenine dinucleotide; Nrf1: nuclear respiratory factor 1; OCR: oxygen consumption rate; PBS: phosphate-buffered saline; PCR: polymerase chain reaction; PPARGC1A: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; Pnpla2: patatin-like phospholipase domain containing 2; Prdm16: PR domain containing 16; PRKA: protein kinase, AMP-activated; RPS6KB: ribosomal protein S6 kinase; RFP: red fluorescent protein; ROS: reactive oxygen species; SD: standard deviation; SEM: standard error of the mean; siRNA: small interfering RNA; SIRT1: sirtuin 1; Sod1: superoxide dismutase 1, soluble; Sod2: superoxide dismutase 2, mitochondrial; SQSTM1: sequestosome 1; T3: 3,5,3ʹ-triiodothyronine; TFEB: transcription factor EB; TOMM20: translocase of outer mitochondrial membrane 20; UCP1: uncoupling protein 1 (mitochondrial, proton carrier); ULK1: unc-51 like kinase 1; VDAC1: voltage-dependent anion channel 1; WAT: white adipose tissue
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“T3 regulates mitochondrial uncoupling by different mechanisms: (1) by sympathetic stimulation [61], (2) by increasing acylcarnitine production [61], thereby activating mitochondrial respiration/uncoupling, and (3) by directly stimulating the transcription of the Ucp1 gene [37].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [61]
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“Indeed, hyperthyroidic Atg5KO mice are characterized by a lower body temperature and lower mitochondrial uncoupling than WT littermates [61].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [61]
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Citations
Cites
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882
Newgard, C. B., An, J., Bain, J. R., Muehlbauer, M. J., Stevens, R. D., Lien, L. F., Haqq, A. M., Shah, S. H., Arlotto, M., Slentz, C. A., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.02.002 · Cited by 3,165
Brown and beige fat: Development, function and therapeutic potential
Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328
Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., & Ohsumi, Y. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0704 · Cited by 2,105
Towards a molecular understanding of adaptive thermogenesis
Lowell, B. B., & Spiegelman, B. M. (2000) · Nature · doi:10.1038/35007527 · Cited by 1,630
Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist
Cypess, A. M., Weiner, L. S., Roberts‐Toler, C., Franquet, E., Kessler, S., Kahn, P. A., English, J., Chatman, K., Trauger, S. A., Doria, A., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.009 · Cited by 1,053
Amino acid signalling upstream of mTOR
Jewell, J. L., Russell, R. C., & Guan, K.-L. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3522 · Cited by 894
Deiodinases: implications of the local control of thyroid hormone action
Bianco, A. C., & Kim, B. W. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29812 · Cited by 845
Regulation of mTORC1 by amino acids
Bar-Peled, L., & Sabatini, D. M. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.03.003 · Cited by 773
Research works printed but not linked: 4
- Obregon MJ, 1989, Am J Physiol, 257, E625
- Hernandez A, 1996, Am J Physiol, 271, E15
- Silva JE, 1986, Am J Physiol, 251, E639
- Lopez-Soriano FJ, 1986, Biochem Int, 12, 471
Cited by
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Items 101–200 of 228
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Li, F., Zhang, F., Yi, X., Quan, L., Yang, X., Yin, C., Ma, Z., Wu, R., Zhao, W., Ling, M., et al. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101747 · Cited by 14
Qi, F., Fu, D., Cai, H., Zheng, Y., Wang, N., & Xu, Z. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202418240 · Cited by 14
Wu, X., Li, J., Chang, K., Yang, F., Jia, Z. H., Sun, C., Li, Q., & Xu, Y. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.158901 · Cited by 14
Nguyen, V. T.-T., Vu, V. V., & Pham, P. V. (2023) · Adipocyte · doi:10.1080/21623945.2023.2237164 · Cited by 15
Takeda, Y., & Dai, P. (2020) · Scientific Reports · doi:10.1038/s41598-020-60769-x · Cited by 13
Zhang, X., Zhan, S., Yang, S., Zhong, T., Guo, J., Cao, J., Wang, Y., Li, L., Zhang, H., & Wang, L. (2021) · Animals · doi:10.3390/ani11051351 · Cited by 13
Leow, M. K., Anantharaj, R., Narasimhan, K., Verma, S. K., Yaligar, J., Le, G. T. T., Sun, L., Goh, H. J., Govindharajulu, P., Sadananthan, S. A., et al. (2022) · Bioscience Reports · doi:10.1042/bsr20212543 · Cited by 12
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de Jong, L. M., Zhang, Z., den Hartog, Y., Sijsenaar, T. J. P., Cardoso, R. M., Manson, M. L., Hankemeier, T., Lindenburg, P. W., Salvatori, D. C. F., Eck, M. V., et al. (2022) · Scientific Reports · doi:10.1038/s41598-021-04524-w · Cited by 12
Wang, Y., Li, J., Lu, D., Meng, Q., Song, N., Zhou, H., Xiao, X., Sun, L., & Zhu, H. (2022) · Journal of Proteomics · doi:10.1016/j.jprot.2022.104500 · Cited by 12
Hu, Y., Zhou, F., Lei, F., Lin, L., Huang, X., Sun, T., Liu, W., Zhang, X., Cai, J., She, Z., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1115354 · Cited by 12
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Maglione, A., do Nascimento, B. P. P., Ribeiro, M. O., de Souza, T. J. L., da Silva, R. E. C., Sato, M. A., Penatti, C. A. A., Britto, L. R., de Souza, J. S., Maciel, R. M. B., et al. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-01055-9 · Cited by 11
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Li, X., Zhao, C., Mao, C., Sun, G., Yang, F., Wang, L., & Wang, X. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167090 · Cited by 11
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Hu, Y., Huang, Y., Jiang, Y., Weng, L., Cai, Z., & He, B. (2024) · Current Obesity Reports · doi:10.1007/s13679-024-00559-y · Cited by 11
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Sun, L., Goh, H. J., Govindharajulu, P., Sun, L., Henry, C. J., & Leow, M. K. (2020) · Scientific Reports · doi:10.1038/s41598-020-66697-0 · Cited by 11
Du, K., Chen, G.-H., Bai, X., Chen, L., Hu, S., Li, Y., Wang, G., He, J.-W., & Lai, S. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.981661 · Cited by 10
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Gao, K., Li, Y., Su, Y., Lin, Z., Yang, X., Xu, M., Huang, Y., Chen, S., Xie, Y., & Li, Z. (2021) · PubMed Central · Cited by 10
Wang, Y., Sun, Y., Wang, Q., Wang, Q., & Kuang, H. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115772 · Cited by 10
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Yu, Z., Yu, T., Li, X., Lin, W., Li, X., Zhai, M., Yin, J., Zhao, L., Liu, X., Zhao, B., et al. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116259 · Cited by 9
Romão, J. S., Neto, J. G. O., de Andrade, C. B. V., de Carvalho, J. J., Pazos-Moura, C. C., & Oliveira, K. J. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123254 · Cited by 9
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Miniewska, K., Godzień, J., Mojsak, P., Maliszewska, K., Kretowski, A. J., & Ciborowski, M. (2020) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2020.113623 · Cited by 10
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Abruzzese, G. A., Arboccó, F. C. V., Ferrer, M. J., Silva, A. F., & Motta, A. B. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-32554-0_2 · Cited by 8
Tripathi, M., Gauthier, K. C., Sandireddy, R., Zhou, J., Guptta, P., Sakthivel, S., Teo, W. W., Naing, Y. T., Arul, K., Tikno, K., et al. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.101997 · Cited by 9
Oh, J.-M., Kim, G., Jeong, J., & Chun, S. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117838 · Cited by 12
Ahmed, F., Hetty, S., Vranic, M., Fanni, G., Kullberg, J., Pereira, M. J., & Eriksson, J. W. (2022) · Adipocyte · doi:10.1080/21623945.2022.2102116 · Cited by 8
Xie, Y., Li, X., Liang, H., Chu, M., Cao, G., & Jiang, Y. (2025) · BMC Genomics · doi:10.1186/s12864-025-11380-9 · Cited by 7
Chen, Q.-C., Cai, W., Ni, Q., Lin, S., Jiang, C., Yi, Y., Liu, L., Liu, Q., & Shen, C. (2025) · International Journal of Obesity · doi:10.1038/s41366-025-01793-7 · Cited by 7
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Ohba, K., & Iwaki, T. (2022) · Endocrine Journal · doi:10.1507/endocrj.ej22-0177 · Cited by 9
Kapri, D., Fanibunda, S. E., & Vaidya, V. A. (2022) · Vitamins and hormones · doi:10.1016/bs.vh.2021.10.001 · Cited by 6
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Li, G.-L., Ping, J., Chen, H.-J., Zhang, W., Fan, J., Peng, D.-S., Zhang, L., & Yan, Y. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118695 · Cited by 6
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Kube‐Golovin, I., Jastrow, H., Führer, D., & Zwanziger, D. (2021) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-1404-7939 · Cited by 4
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Huang, J., Zhou, C., Yu, Z., Song, Z., Deng, H., Chao, H., & Zeng, T. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1603069 · Cited by 3
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Jia, F., Wang, Y., Gao, S., Zhang, R. L., Chen, S., Zhang, H., Ma, Y., Zhang, Z., Guo, J., Zhang, X., et al. (2026) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(26)61104-1 · Cited by 3
Liu, S., Zhao, J., Dong, S., Zhang, Y., Zhao, Y., Ran, N., Yang, G., Peng, C., Yang, X., Song, G., et al. (2026) · Phytotherapy Research · doi:10.1002/ptr.70291 · Cited by 3
Liu, J., Wang, Z., Wang, H., Yu, L., Yu, Y., & Sun, H. (2025) · Journal of Neuroendocrinology · doi:10.1111/jne.70093 · Cited by 4
Gureev, A. P., Alimova, A. A., Silachev, D. N., & Plotnikov, E. Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216491 · Cited by 3
Fan, C., Ren, Y., Zhang, W., Wen, J., Zhang, W., Lin, S., Bai, Y., Zheng, T., Abay, B., Li, M., et al. (2024) · Mitochondrion · doi:10.1016/j.mito.2024.101919 · Cited by 3
Altinoz, M. A., Serdar, M. A., Altinoz, S. M., Eroğlu, M., Muhçu, M., Kumru, P., & Özpınar, A. (2025) · Nutrients · doi:10.3390/nu17122017 · Cited by 3
Liao, L., Feng, J., Fu, X., Cao, L., Fan, M., Huang, C., Zhang, J., Zhang, L., Chen, P., & You, F. (2022) · Journal of Healthcare Engineering · doi:10.1155/2022/9274060 · Cited by 3
RetractedGutiérrez-García, A., Olivas-Aguirre, F. J., & Olivas-Aguirre, M. (2025) · Receptors · doi:10.3390/receptors4040019 · Cited by 2
Integrating bile acid metabolism into precision nutrition strategies for improved swine performance
Li, S., He, Y., Shaoyong, W., Wang, Y., & Jin, M. (2025) · Animal nutrition · doi:10.1016/j.aninu.2025.05.013 · Cited by 2
Mitophagy in bladder cancer: a double-edged sword in tumor progression and therapy
Chen, Q., Chen, T., Gan, L., Lu, Y., & Qian, B. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08042-z · Cited by 2
Yin, X., Xu, Z., Zhang, X., Wu, J., & Lu, W. (2023) · Cell Cycle · doi:10.1080/15384101.2023.2169521 · Cited by 2
Subcutaneous adipose tissue alteration in aging process associated with thyroid hormone signaling
Zhang, W., Zhu, H., Ma, Z., Yu, J., Yang, Y., Lu, X.-B., Lv, Y., & Wang, X. (2023) · BMC Medical Genomics · doi:10.1186/s12920-023-01641-5 · Cited by 2
Hyperactive browning and hypermetabolism: potentially dangerous element in critical illness
Huang, L., Zhu, L., Zhao, Z., & Jiang, S. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1484524 · Cited by 2
Xie, L., Yang, S., Chen, M., Li, J., He, Y., Peng, C., Xu, Y., Huang, W., Luo, T., Yu, F. H. Z., et al. (2025) · The FASEB Journal · doi:10.1096/fj.202500698r · Cited by 2
Chen, H., Jia, T., Wang, Z., & Zhu, W. (2023) · Journal of Experimental Zoology Part A Ecological and Integrative Physiology · doi:10.1002/jez.2680 · Cited by 2
Transcriptome dataset of mouse adipose tissue across estrous cycles
Zheng, H., Bai, Y., Wu, S., Jiang, Z., Pei, Q., & Yao, M. (2024) · Scientific Data · doi:10.1038/s41597-024-03942-5 · Cited by 2
Sex-specific differences in mitochondrial function and its role in health disparities
Mishra, S., & Singh, K. K. (2023) · Principles of Gender-Specific Medicine · doi:10.1016/b978-0-323-88534-8.00014-6 · Cited by 1
APOC1 inhibit NKTCL doxorubicin sensitivity by promoting mitophagy
Xiao, S., Kuang, J., yang, J., Wang, H., sun, Y., Zhang, H., Zhang, Z., Shi, M., Qi, K., Jiang, M., et al. (2025) · IUBMB Life · doi:10.1002/iub.2942 · Cited by 1
Zhang, K., He, S., Wang, Q. Y., Li, J.-J., Yao, C., Shan, C., Zhang, L., Zhong-ying, L., Liu, P., Li, M.-Y., et al. (2025) · Animals · doi:10.3390/ani15050692 · Cited by 1
Another pleiotropic effect of SGLT2 inhibitors: Is it a new frontier in thyroid function regulation?
Szklarz, M., Wołos-Kłosowicz, K., Szulc, J., Górny, J. M., Modzelewski, R., & Matuszewski, W. (2026) · Thyroid Research · doi:10.1186/s13044-025-00282-3 · Cited by 1
Functional role of THRAP3 in modulating thyroid hormone–mediated gene networks in C2C12 myotubes
Fukushima, T., Kuse, S., Hasegawa, Y., Fujioka, T., Nikawa, T., Masubuchi, S., & Sakakibara, I. (2026) · PLoS ONE · doi:10.1371/journal.pone.0341353 · Cited by 1
The Role of Iron in Adipose Tissue Function, Crosstalk, and Transdifferentiation
Guo, J., Yu, P., 李陈康, 聂桂英, Xu, W., Chen, M., Li, L., Peng, T., & Xie, W. (2026) · Cell Biochemistry and Function · doi:10.1002/cbf.70229 · Cited by 1
Huang, W., Yao, J., Shi, Y., & Huang, H. (2026) · International Journal of Endocrinology · doi:10.1155/ije/9291433 · Cited by 1
Non-shivering thermogenesis and its current advances in clinical trials targeting obesity
Wu, Z. (2022) · Highlights in Science Engineering and Technology · doi:10.54097/hset.v8i.1212 · Cited by 1
Tripathi, M., Gauthier, K. C., Sandireddy, R., Zhou, J., Gupta, P. S., Sakthivel, S., Teo, W. W., Naing, Y. T., Arul, K., Tikno, K., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.16.468891 · Cited by 1
Metadata
- Authors
- Yau, W. W., Singh, B. K., Lesmana, R., Zhou, J., Sinha, R. A., Wong, K. A., Wu, Y., Bay, B.-H., Sugii, S., Sun, L., & Yen, P. M.
- Affiliations
- National University of Singapore (SG)
- Sanjay Gandhi Post Graduate Institute of Medical Sciences (IN)
- Agency for Science, Technology and Research (SG)
- Corresponding author
- Yen, Paul M.
- ORCID
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2018-09-13
- Volume
- 15
- Issue
- 1
- Pages
- 131-150
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- PMC
- PMC6287687
- OpenAlex
- W2889919383
- Cited by
- 229
- References
- 67
- Citations by year
- 2026: 18 · 2025: 33 · 2024: 39 · 2023: 35 · 2022: 39 · 2021: 30 · 2020: 25 · 2019: 9 · 2018: 1
- FWCI
- 11.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Autophagy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Funders
- MOH | National Medical Research Council (NMRC) (NMRC/CIRG/1457/2016, NMRC/CSA/ 0054/2013, NMRC/OFYIRG/0002/2016, NMRC/CIRG/1340/2012)
- Agency for Science, Technology and Research (A*STAR) (R-913-301-197-304)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- triiodothyronine, thyroid hormones, brown adipose tissue, thermogenesis, mitochondrial biogenesis, mitophagy, mTOR, SIRT1, fatty acid oxidation, mitochondrial respiration, reactive oxygen species, UCP1, acylcarnitines, fatty acid beta-oxidation, obesity, hyperthyroidism, body temperature
- MeSH terms
- Animals, Organelle Biogenesis, Adipose Tissue, Brown, Cells, Cultured, Hyperthyroidism, Male, Mice, Inbred C57BL, Mitochondria, Triiodothyronine, Signal Transduction, Mice, Knockout, Mice, TOR Serine-Threonine Kinases, Mitophagy
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