Effects of anatomical location on in vivo percutaneous penetration in man
Abstract
Purpose Percutaneous penetration in man is affected by several factors: chemical properties, skin anatomy variables, and environmental conditions can all modify the quantity of chemical that penetrates through the skin barrier. The amount of chemical or drug that penetrates the cutaneous barrier must be considered due to the local and systemic absorption that may occur. Regional variation in percutaneous absorption is an additional factor to recognize when analysing chemical percutaneous penetration. Although it has been studied that certain anatomic sites allow for increased absorption, there is limited literature regarding in vivo data in man. This overview catalogues and analyses studies performed in man to quantify chemical permeation at varying anatomical locations. We also review what is known about the pharmacokinetics of Food and Drug Administration approved medication patches and semisolids and the regional variation in absorption that they may display. This research work aims to create an updated, concise overview of the pertinent studies available regarding percutaneous penetration and regional variability. Materials and methods We searched PubMed, Web of Science, Google Scholar and the United States Food and Drug Administration's online database for approved transdermal delivery systems from January 1965 to March 2020, with the search words: percutaneous absorption, regional variation, anatomical location, along with extensive bibliographical review. We further ut…
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In humans, dosed substances are absorbed more readily around the face, which is considered to have thinner skin than the trunk and limbs, suggesting that absorption depends on skin thickness.
“In humans, dosed substances are absorbed more readily around the face, which is considered to have thinner skin than that around the trunk and limbs, suggesting that it depends on the thickness of the skin50, 51.”
From Morphological characteristics and notes of the skin in preclinical toxicity assessment (2023) · cites this paper as [50]
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- Authors
- Bormann, J. L., & Maibach, H. I.
- Affiliations
- University of South Dakota (US)
- Dermatology Department, UCSF, San Francisco, CA, USA
- Corresponding author
- Bormann, Jordan L.
- ORCID
- Bormann, Jordan L.
- Venue
- Cutaneous and Ocular Toxicology
- Publisher
- Informa UK Limited
- Published
- 2020-07-02
- Volume
- 39
- Issue
- 3
- Pages
- 213-222
- ISSN
- 1556-9527 (ISSN-L)
- 1556-9535
- OpenAlex
- W3041609207
- Cited by
- 28
- References
- 35
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 4
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cutaneous and Ocular Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- percutaneous absorption, anatomical location, transdermal drug delivery, transdermal patch, pharmacokinetics, skin barrier
- MeSH terms
- Administration, Cutaneous, Pharmaceutical Preparations, Humans, Skin, Skin Absorption
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