CoChat
Sign Up
Cited by 16Attention Deficit Hyperactivity DisorderAdvancements in Transdermal Drug DeliveryPharmaceutical studies and practices

Effects of Application to Two Different Skin Sites on the Pharmacokinetics of Transdermal Methylphenidate in Pediatric Patients with Attention-Deficit/Hyperactivity Disorder

González, Mario A., Campbell, Dawn, Rubin, Jonathan·2009·Journal of Child and Adolescent Psychopharmacology
DOI 10.1089/cap.2008.0081
Open this paper in CoChat — free account

Abstract

Objective: This study was conducted to quantify the rate and extent of methylphenidate (MPH) absorption from a transdermal system when applied to two different skin sites in pediatric subjects with attention-deficit/hyperactivity disorder (ADHD). Methods: In an open-label, single-dose, randomized, two-way crossover study, children (6–12 years) with ADHD were randomized to wear one MPH transdermal system (MTS) on the hip area or on the scapular area for 16 hours. The following week, subjects were crossed over to the opposite application site. Serial blood samples were collected after each MTS application and pharmacokinetic (PK) parameters for d,l -MPH were calculated. Worn MTS units were assayed to calculate the Apparent Dose absorbed from MTS. Results: PK analyses included 23 subjects. Hip and scapular application resulted in quantifiable levels of d,l -MPH, with approximately 31% higher bioavailability upon hip application. Logarithm transformed mean ratios for area under the curve (AUC) and C max indicated a lack of equivalence between the two sites. Conclusion: MTS applied to both hip and scapular areas resulted in quantifiable plasma levels of d,l -MPH. Bioavailability of MPH from the same transdermal delivery system appears to differ substantially when applied to two different skin surfaces in young children but with similar overall skin effects assessments.

Integrity signals

Registry

Crossref · 10.1089/cap.2008.0081

Cites

15 of 15 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Greater absorption of methylphenidate occurs when the patch is applied to the buttocks rather than to the subscapular area.

    “Greater absorption of medication occurs when the patch is applied to the buttocks rather than to the subscapular area [47].”

    From Advances in understanding and treating ADHD (2011) · cites this paper as [47]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
González, M. A., Campbell, D., & Rubin, J.
Affiliations
  • P'Kinetics International, Inc.
  • DAC and Associates Consulting
  • Takeda (United States) (US)
ORCID
Rubin, Jonathan
Venue
Journal of Child and Adolescent Psychopharmacology
Publisher
SAGE Publications
Published
2009-06
Volume
19
Issue
3
Pages
227-232
ISSN
  • 1044-5463 (ISSN-L)
  • 1557-8992
DOI
10.1089/cap.2008.0081
OpenAlex
W1992397132
Cited by
16
References
15
Citations by year
2025: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2017: 1 · 2014: 1 · 2013: 1
FWCI
1.64
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Journal of Child and Adolescent Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
Keywords
methylphenidate, transdermal drug delivery, attention deficit hyperactivity disorder, pediatric patients, pharmacokinetics, bioavailability, skin effect
MeSH terms
Administration, Cutaneous, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Biological Availability, Female, Hip, Humans, Male, Methylphenidate, Scapula, Skin Absorption, Cross-Over Studies, Area Under Curve

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review