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Moderate alcohol use and reduced mortality risk: Systematic error in prospective studies

Fillmore, Kaye Middleton, Kerr, William C., Stockwell, Tim, Chikritzhs, Tanya, Bostrom, Alan·2006·Addiction Research & Theory

DOI 10.1080/16066350500497983

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Abstract

The majority of prospective studies on alcohol use and mortality risk indicates that abstainers are at increased risk of mortality from both all causes and coronary heart disease (CHD). This meta-analysis of 54 published studies tested the extent to which a systematic misclassification error was committed by including as ‘abstainers’ many people who had reduced or stopped drinking, a phenomenon associated with ageing and ill health. The studies judged to be error free found no significant all-cause or cardiac protection, suggesting that the cardiac protection afforded by alcohol may have been over-estimated. Estimates of mortality from heavier drinking may also be higher than previously estimated.

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Authors: Fillmore, K. M., Kerr, W. C., Stockwell, T., Chikritzhs, T., & Bostrom, A.
Affiliations: University of California, San Francisco (US)
Alcohol Research Group (US)
University of Victoria (CA)
Curtin University (AU)
Corresponding author: Fillmore, Kaye Middleton
ORCID: Kerr, William C.
Stockwell, Tim
Chikritzhs, Tanya
Venue: Addiction Research & Theory
Publisher: Informa UK Limited
Published: 2006-01
Volume: 14
Issue: 2
Pages: 101-132
ISSN: 1058-6989 (ISSN-L)
1606-6359
1476-7392
DOI: 10.1080/16066350500497983
OpenAlex: W2058841902
Cited by: 295
References: 114
Citations by year: 2026: 5 · 2025: 8 · 2024: 5 · 2023: 2 · 2022: 9 · 2021: 9 · 2020: 10 · 2019: 6 · 2018: 13 · 2017: 11 · 2016: 22 · 2015: 13 · 2014: 14 · 2013: 23 · 2012: 20
FWCI: 21.46
Type: journal article
Language: en
Open access: closed
Locations: Addiction Research & Theory (publishedVersion)
eSpace (Curtin University) (submittedVersion)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Keywords: alcohol consumption, mortality risk, coronary artery disease, all-cause mortality, misclassification, heavy drinking, aging, prospective study, cardioprotection

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Moderate alcohol use and reduced mortality risk: Systematic error in prospective studies

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