Alcohol and coronary heart disease: a meta-analysis.
Abstract
Objective To estimate parameters of the function relating alcohol consumption with the risk of coronary heart disease and to identify the sources of heterogeneity in the parameter estimates. Methods A search of the epidemiological literature from 1966 to 1998 was performed using several bibliographic databases. Meta-regression models were fitted to evaluate non-linear effects of alcohol intake on the relative risk. The effects of some characteristics of the studies, including an index of their quality, were considered as putative sources of heterogeneity of the estimates. Publication bias was also investigated. Findings Among the 196 initially reviewed articles, 51 were selected. Since qualitative characteristics of the studies were significant sources of heterogeneity, the pooled dose-response functions were based on the 28 cohort studies with higher quality. Risk decreased from 0 to 20 g/day (RR = 0.80; 95% CI: 0.78, 0.83); there was evidence of a protective effect up to 72 g/day (RR = 0.96; 95% CI: 0.92, 1.00) and increased risk above > or = 89 g/day (RR = 1.05; 95% CI: 1.00, 1.11). Lower protective effects and harmful effects were found in women, in men living in countries outside the Mediterranean area and in studies where fatal events were used as the outcome. Evidence of publication bias for moderate intakes and of heterogeneity of the estimates across studies for higher intakes were found. Conclusions The degree of protection from moderate doses of alcohol should be r…
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Alcohol use may be beneficial or harmful depending on the specific disease outcome and patterns of alcohol consumption.
“Alcohol use may be beneficial or harmful depending on the specific disease outcome and patterns of alcohol consumption [29], [30].”
From The Preventable Causes of Death in the United States: Comparative Risk Assessment of Dietary, Lifestyle, and Metabolic Risk Factors (2009) · cites this paper as [30]
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- Authors
- Corrao, G., Rubbiati, L., Bagnardi, V., Zambon, A., & Poikolainen, K.
- Affiliations
- University of Milano-Bicocca (IT)
- Venue
- Addiction
- Publisher
- Wiley
- Published
- 2000-10
- Volume
- 95
- Issue
- 10
- Pages
- 1505-1523
- ISSN
- 0965-2140 (ISSN-L)
- 1360-0443
- OpenAlex
- W1979209029
- Cited by
- 875
- References
- 0
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 12 · 2023: 17 · 2022: 14 · 2021: 24 · 2020: 18 · 2019: 24 · 2018: 37 · 2017: 29 · 2016: 26 · 2015: 33 · 2014: 47 · 2013: 55 · 2012: 58
- FWCI
- 17.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Addiction (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- alcohol consumption, coronary artery disease, dose-response relationship, moderate drinking, protective effect of alcohol, publication bias, study quality, sex differences, Mediterranean countries, drinking patterns
- MeSH terms
- Alcohol Drinking, Coronary Disease, Dose-Response Relationship, Drug, Female, Humans, Male, Mathematical Computing, Regression Analysis, Research Design, Risk Factors, Sex Factors, Confidence Intervals, Odds Ratio, Publication Bias
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