The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Heterotopic ossification: A review
Open accessAbstract
Heterotopic ossification is defined as the presence of lamellar bone at locations where bone normally does not exist. The condition must be distinguished from metastatic calcifications, which mainly occur in hypercalcaemia, and dystrophic calcifications in tumours. It is a frequent complication following central nervous system disorders (brain injuries, tumours, encephalitis, spinal cord lesions), multiple injuries, hip surgery and burns. In addition to this acquired form, hereditary causes also exist, such as fibrodysplasia ossificans progressiva, progressive osseous heteroplasia and Albright's hereditary osteodystrophy. Although these conditions are extremely rare, they can provide useful information on the physiopathology of heterotopic ossification, and thus lead to novel and causal treatment modalities. Heterotopic ossification is no trivial complication. A limitation of the range of joint motion may have serious consequences for the daily functioning of people who are already severely incapacitated because of their original lesion. Increased contractures and spasticity, pressure ulcers and increasing pain further compromise the patient's capabilities. Consequently, we feel that attention should be paid to the pathogenesis and particularly the prevention and treatment of this disorder.
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Cites
Ectopic Ossification Following Total Hip Replacement: INCIDENCE AND A METHOD OF CLASSIFICATION
BROOKER, A. F., BOWERMAN, J. W., ROBINSON, R. A., & RILEY, L. H. (1973) · The Journal of Bone & Joint Surgery · doi:10.2106/00004623-197355080-00006 · Cited by 2,800
Ectopic Ossification Following Total Hip Replacement: Incidence and a Method of Classification
Banaszkiewicz, P. A. (2014) · Classic Papers in Orthopaedics · doi:10.1007/978-1-4471-5451-8_25 · Cited by 2,537
A Clinical Perspective on Common Forms of Acquired Heterotopic Ossification
GARLAND, D. E. (1991) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199102000-00003 · Cited by 447
Ritter, M., & Vaughan, R. (1977) · The Journal of Bone & Joint Surgery · doi:10.2106/00004623-197759030-00009 · Cited by 304
Neurogenic heterotopic ossification in spinal cord injury
van Kuijk, A., Geurts, A., & van Kuppevelt, H. (2002) · Spinal Cord · doi:10.1038/sj.sc.3101309 · Cited by 268
Jee, W. S. S., Ueno, K., Deng, Y. P., & Woodbury, D. M. (1985) · Calcified Tissue International · doi:10.1007/bf02554834 · Cited by 245
Genetic Mapping of Ossification of the Posterior Longitudinal Ligament of the Spine
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Cited by
Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists
Shimono, K., Tung, W.-E., Macolino, C., Chi, A. H.-T., Didizian, J. H., Mundy, C., Chandraratna, R. A., Mishina, Y., Enomoto-Iwamoto, M., Pacifici, M., et al. (2011) · Nature Medicine · doi:10.1038/nm.2334 · Cited by 334
ANGPTL4 binds to the leptin receptor to regulate ectopic bone formation
Hu, H., Luo, S., Lai, P., Lai, M., Mao, L., Zhang, S., Jiang, Y., Wen, J., Zhou, W., Liu, X., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2310685120 · Cited by 18
Metadata
- Authors
- Vanden Bossche, L., & Vanderstraeten, G.
- Venue
- Journal of Rehabilitation Medicine
- Publisher
- Medical Journals Sweden AB
- Published
- 2005-05-01
- Volume
- 37
- Issue
- 3
- Pages
- 129-136
- ISSN
- 1650-1977 (ISSN-L)
- OpenAlex
- W2065885294
- Cited by
- 448
- References
- 15
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
