Cited by 105Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsBlood properties and coagulation

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The effects of particle size, shape, density and flow characteristics on particle margination to vascular walls in cardiovascular diseases

Ta, Hang T., Truong, Nghia P., Whittaker, Andrew K., Davis, Thomas P., Peter, Karlheinz·2018·Expert Opinion on Drug Delivery

DOI 10.1080/17425247.2017.1316262

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Abstract

INTRODUCTION: Vascular-targeted drug delivery is a promising approach for the treatment of atherosclerosis, due to the vast involvement of endothelium in the initiation and growth of plaque, a characteristic of atherosclerosis. One of the major challenges in carrier design for targeting cardiovascular diseases (CVD) is that carriers must be able to navigate the circulation system and efficiently marginate to the endothelium in order to interact with the target receptors. AREAS COVERED: This review draws on studies that have focused on the role of particle size, shape, and density (along with flow hemodynamics and hemorheology) on the localization of the particles to activated endothelial cell surfaces and vascular walls under different flow conditions, especially those relevant to atherosclerosis. EXPERT OPINION: Generally, the size, shape, and density of a particle affect its adhesion to vascular walls synergistically, and these three factors should be considered simultaneously when designing an optimal carrier for targeting CVD. Available preliminary data should encourage more studies to be conducted to investigate the use of nano-constructs, characterized by a sub-micrometer size, a non-spherical shape, and a high material density to maximize vascular wall margination and minimize capillary entrapment, as carriers for targeting CVD.

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Authors: Ta, H. T., Truong, N. P., Whittaker, A. K., Davis, T. P., & Peter, K.
Affiliations: The University of Queensland (AU)
Monash University (AU)
University of Warwick (GB)
Baker Heart and Diabetes Institute (AU)
Corresponding author: Ta, Hang T.
Peter, Karlheinz
ORCID: Ta, Hang T.
Truong, Nghia P.
Whittaker, Andrew K.
Davis, Thomas P.
Peter, Karlheinz
Venue: Expert Opinion on Drug Delivery
Publisher: Informa UK Limited
Published: 2017-04-13
Volume: 15
Issue: 1
Pages: 33-45
ISSN: 1742-5247 (ISSN-L)
1744-7593
DOI: 10.1080/17425247.2017.1316262
OpenAlex: W2604413746
Cited by: 105
References: 112
Citations by year: 2026: 11 · 2025: 7 · 2024: 10 · 2023: 13 · 2022: 9 · 2021: 17 · 2020: 13 · 2019: 12 · 2018: 9 · 2017: 4
FWCI: 0.76
Type: journal article
Language: en
Open access: closed
Locations: Expert Opinion on Drug Delivery (publishedVersion)
PubMed (publishedVersion)
Griffith Research Online (submittedVersion)
Warwick Research Archive Portal (University of Warwick) (submittedVersion)
Funders: Australian Research Council (CE140100036)
National Health and Medical Research Council (APP1037310, FT0992210)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Health Sciences › Medicine › Hematology › Blood properties and coagulation
Keywords: vascular wall, atherosclerosis, particle size, particle shape, particle density, hemorheology, endothelial cell adhesion, cardiovascular disease
MeSH terms: Coronary Artery Disease, Coronary Vessels, Densitometry, Drug Carriers, Endothelium, Vascular, Hemodynamics, Humans, Particle Size, Drug Delivery Systems

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The effects of particle size, shape, density and flow characteristics on particle margination to vascular walls in cardiovascular diseases

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