Rejection of the Kidney Allograft
Abstract
This review gives an account of our current understanding of the mechanisms of rejection of renal allografts. New immunosuppressive agents show promise, but graft survival beyond 5 years has not improved substantially.
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The immune mechanisms leading to allograft rejection while on ICIs remain poorly understood.
“the immune mechanisms leading to allograft rejection while on ICIs remain poorly understood11.”
From Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation (2019) · cites this paper as [11]
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- Authors
- Nankivell, B. J., & Alexander, S. I.
- Affiliations
- The University of Sydney (AU)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2010-10-07
- Volume
- 363
- Issue
- 15
- Pages
- 1451-1462
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2051872988
- Cited by
- 605
- References
- 74
- Citations by year
- 2026: 23 · 2025: 23 · 2024: 25 · 2023: 27 · 2022: 39 · 2021: 32 · 2020: 46 · 2019: 41 · 2018: 40 · 2017: 53 · 2016: 50 · 2015: 50 · 2014: 44 · 2013: 45 · 2012: 46
- FWCI
- 5.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Transplantation › Organ and Tissue Transplantation Research
- Keywords
- kidney transplantation, allograft rejection, rejection mechanisms, immunosuppressants, graft survival, renal allograft
- MeSH terms
- Antibodies, Arteritis, Blood Group Antigens, Graft Rejection, Humans, Immunity, Innate, Isoantigens, Kidney, Major Histocompatibility Complex, T-Lymphocytes, Transplantation Immunology, Transplantation, Homologous, Kidney Transplantation
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