Pulmonary exposure to metallic nanomaterials during pregnancy irreversibly impairs lung development of the offspring
Open accessAbstract
Due to the growing commercial applications of manufactured nanoparticles (NPs), toxicological studies on NPs, especially during the critical window of development, are of major importance. The aim of the study was to assess the impact of respiratory exposure to metallic and metal oxide NPs during pregnancy on lung development of the offspring and to determine the key parameters involved in lung alterations. Pregnant mice were exposed to weekly doses of 100 μg (total dose 300 μg) of titanium dioxide (TiO2), cerium oxide (CeO2), silver (Ag) NPs or saline solution by nonsurgical intratracheal instillation. The offspring lungs were analyzed at different stages of lung development: fetal stage (gestational day 17.5), pulmonary alveolarization (post-delivery day 14.5) and lung maturity (post-delivery day 49.5). Regardless of the type of NP, maternal exposure during gestation induced long-lasting impairment of lung development of the offspring. This effect was accompanied by: i) decreased placental efficiency together with the presence of NPs in placenta, ii) no increase of inflammatory mediators present in amniotic fluid, placenta or offspring lungs and iii) decreased pulmonary expression of vascular endothelial growth factor-α (VEGF-α) and matrix metalloproteinase 9 (MMP-9) at the fetal stage, and fibroblast growth factor-18 (FGF-18) at the alveolarization stage. Respiratory exposure to metallic NPs during pregnancy induces stereotyped impairment of lung development with a lasting effect in adult mice, independently of the chemical nature of the NP.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Gestational exposure to titanium dioxide, cerium oxide, and silver nanoparticles induced stereotyped impairment of lung development with lasting effects in adult mice, independent of nanoparticle chemical nature, indicating particle size played a primary role.
“Paul et al. [106] showed gestational exposure to titanium dioxide (TiO2), cerium oxide (CeO2), and silver nanoparticles-induced stereotyped impairment of lung development (decreased radial alveolar count/alveolar surface) with lasting effects in adult mice. These effects were independent of the chemical nature of the nanoparticles indicating particle size played a primary role.”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [106]
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredDecreased placental efficiency with the presence of metallic nanoparticles in the placenta was confirmed in a mouse model and correlated with impaired lung development in offspring that persisted into adulthood.
“In another mouse model, Paul et al. [106] confirmed decreased placental efficiency with the presence of metallic nanoparticles in the placenta. This correlated with impaired lung development in offspring that persisted into adulthood.”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [106]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
ATHENA , ARTEMIS , HEPHAESTUS : data analysis for X-ray absorption spectroscopy using IFEFFIT
Ravel, B., & Newville, M. G. (2005) · Journal of Synchrotron Radiation · doi:10.1107/s0909049505012719 · Cited by 16,981 · see citing works
A multiplatform code for the analysis of energy-dispersive X-ray fluorescence spectra
Solé, V. A., Papillon, E., Cotte, M., Walter, P., & Susini, J. (2006) · Spectrochimica Acta Part B Atomic Spectroscopy · doi:10.1016/j.sab.2006.12.002 · Cited by 2,260 · see citing works
Titanium dioxide nanoparticles: a review of current toxicological data
Shi, H., Magaye, R., Castranova, V., & Zhao, J. (2013) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-10-15 · Cited by 1,509 · see citing works
Chronic Lung Disease after Premature Birth
Baraldi, E., & Filippone, M. (2007) · New England Journal of Medicine · doi:10.1056/nejmra067279 · Cited by 1,071 · see citing works
Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology
Oberdörster, G. (2009) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2009.02187.x · Cited by 943 · see citing works
Silica and titanium dioxide nanoparticles cause pregnancy complications in mice
Yamashita, K., Yoshioka, Y., Higashisaka, K., Mimura, K., Morishita, Y., Nozaki, M., Yoshida, T., Ogura, T., Nabeshi, H., Nagano, K., et al. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.41 · Cited by 739 · see citing works
Inhibition of angiogenesis decreases alveolarization in the developing rat lung
Jakkula, M., Cras, T. D. L., Gebb, S. A., Hirth, K. P., Tuder, R. M., Voelkel, N. F., & Abman, S. H. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.3.l600 · Cited by 677 · see citing works
Measurement of nanoparticles by light-scattering techniques
Brar, S. K., & Verma, M. (2010) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2010.08.008 · Cited by 446 · see citing works
Emery, J. L., & Mithal, A. (1960) · Archives of Disease in Childhood · doi:10.1136/adc.35.184.544 · Cited by 432 · see citing works
Emphysema in young adult survivors of moderate-to-severe bronchopulmonary dysplasia
Wong, P. M., Lees, A., Louw, J., Lee, F. Y., French, N., Gain, K. R., Murray, C. P. J., Wilson, A. C., & Chambers, D. C. (2008) · European Respiratory Journal · doi:10.1183/09031936.00127107 · Cited by 310 · see citing works
Shen, W., Zhang, X., Huang, Q., Xu, Q., & Song, W. (2013) · Nanoscale · doi:10.1039/c3nr05479a · Cited by 288 · see citing works
Rosenberg, A. A. (2008) · Seminars in Perinatology · doi:10.1053/j.semperi.2007.11.003 · Cited by 277 · see citing works
Shimizu, M., Tainaka, H., Oba, T., Mizuo, K., Umezawa, M., & Takeda, K. (2009) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-6-20 · Cited by 272 · see citing works
Engineered Nanomaterials in Food: Implications for Food Safety and Consumer Health
Martirosyan, A. S., & Schneider, Y. (2014) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph110605720 · Cited by 263 · see citing works
Prenatal inflammation and lung development
Kramer, B. W. W., Kallapur, S. G., Newnham, J. P., & Jobe, A. H. (2008) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2008.08.011 · Cited by 252 · see citing works
Labille, J., Feng, J., Botta, C., Borschneck, D., Sammut, M. L., Cabié, M., Auffan, M., Rose, J., & Bottero, J. (2010) · Environmental Pollution · doi:10.1016/j.envpol.2010.02.012 · Cited by 240 · see citing works
Self-citationSmith, B. R., Ghosn, E., Rallapalli, H., Prescher, J. A., Larson, T. A., Herzenberg, L. A., & Gambhir, S. S. (2014) · Nature Nanotechnology · doi:10.1038/nnano.2014.62 · Cited by 238 · see citing works
Hougaard, K. S., Jackson, P., Jensen, K. A., Sloth, J. J., Loeschner, K., Larsen, E. H., Birkedal, R. K., Vibenholt, A., Boisen, A. M. Z., Wallin, H., et al. (2010) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-7-16 · Cited by 238 · see citing works
Cooney, T. P., & Thurlbeck, W. M. (1982) · Thorax · doi:10.1136/thx.37.8.580 · Cited by 213 · see citing works
Acute inhalation toxicity of cerium oxide nanoparticles in rats
Srinivas, A., Rao, P. J., Selvam, G., Murthy, P. B., & Reddy, P. N. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.05.1027 · Cited by 211 · see citing works
Lu, Z., Xiao, J., Wang, Y., & Meng, M. (2015) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2015.04.015 · Cited by 197 · see citing works
Sulfidation Mechanism for Zinc Oxide Nanoparticles and the Effect of Sulfidation on Their Solubility
Ma, R., Levard, C., Michel, F. M., Brown, G. E., & Lowry, G. V. (2013) · Environmental Science & Technology · doi:10.1021/es3035347 · Cited by 188 · see citing works
Rice, S. B., Chan, C. D., Brown, S. C., Eschbach, P. A., Han, L., Ensor, D., Stefaniak, A. B., Bonevich, J. E., Vladár, A. E., Walker, A. R. H., et al. (2013) · Metrologia · doi:10.1088/0026-1394/50/6/663 · Cited by 170 · see citing works
Tang, J., Karumanchi, S. A., Seedorf, G., Markham, N. E., & Abman, S. H. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00294.2011 · Cited by 151 · see citing works
Induction of pulmonary fibrosis by cerium oxide nanoparticles
Ma, J. Y., Mercer, R. R., Barger, M., Schwegler-Berry, D., Scabilloni, J., Ma, J. K., & Castranova, V. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.05.005 · Cited by 142 · see citing works
Philbrook, N. A., Winn, L. M., Afrooz, A. R. M. N., Saleh, N. B., & Walker, V. K. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.09.027 · Cited by 137 · see citing works
Sheikpranbabu, S., Kalishwaralal, K., Venkataraman, D., Eom, S. H., Park, J., & Gurunathan, S. (2009) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-7-8 · Cited by 129 · see citing works
Exposure assessment of workplaces manufacturing nanosized TiO2and silver
Lee, J. H., Kwon, M., Ji, J. H., Kang, C. S., Ahn, K. H., Han, J. H., & Yu, I. J. (2011) · Inhalation Toxicology · doi:10.3109/08958378.2011.562567 · Cited by 127 · see citing works
Valentino, S. A., Tarrade, A., Aioun, J., Mourier, E., Richard, C., Dahirel, M., Rousseau-Ralliard, D., Fournier, N., Aubrière, M.-C., Lallemand, M.-S., et al. (2015) · Particle and Fibre Toxicology · doi:10.1186/s12989-016-0151-7 · Cited by 124 · see citing works
Persistent Effects of Maternal Smoking during Pregnancy on Lung Function and Asthma in Adolescents
Hollams, E. M., de Klerk, N. H., Holt, P. G., & Sly, P. D. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201302-0323oc · Cited by 122 · see citing works
Fetal Growth Restriction Has Long-Term Effects on Postnatal Lung Structure in Sheep
Maritz, G. S., Cock, M. L., Louey, S., Suzuki, K., & Harding, R. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000106314.99930.65 · Cited by 121 · see citing works
Pulmonary Toxicity of Instilled Silver Nanoparticles: Influence of Size, Coating and Rat Strain
Seiffert, J. M., Hussain, F., Wiegman, C., Li, F., Bey, L., Baker, W., Porter, A. E., Ryan, M. P., Chang, Y. H., Gow, A. J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119726 · Cited by 121 · see citing works
Mitigation of endometriosis using regenerative cerium oxide nanoparticles
Chaudhury, K., Narendra Babu, K., Singh, A. K., Das, S., Kumar, A., & Seal, S. (2012) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2012.08.001 · Cited by 118 · see citing works
Vantelon, D., Trcera, N., Roy, D., Moreno, T., Mailly, D., Guilet, S., Metchalkov, E., Delmotte, F., Lassalle‐Kaiser, B., Lagarde, P., et al. (2016) · Journal of Synchrotron Radiation · doi:10.1107/s1600577516000746 · Cited by 115 · see citing works
Self-citationNanomaterials and regulation of cosmetics
Bowman, D. M., CALSTER, G. V., & Friedrichs, S. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2010.12 · Cited by 112 · see citing works
Morimoto, Y., Izumi, H., Yoshiura, Y., Tomonaga, T., Lee, B.-W., Okada, T., Oyabu, T., Myojo, T., Kawai, K., Yatera, K., et al. (2015) · Nanotoxicology · doi:10.3109/17435390.2015.1104740 · Cited by 98 · see citing works
Damaging Effects of Multi-walled Carbon Nanotubes on Pregnant Mice with Different Pregnancy Times
Qi, W., Bi, J., Zhang, X., Wang, J., Wang, J., Liu, P., Li, Z., & Wu, W. (2014) · Scientific Reports · doi:10.1038/srep04352 · Cited by 92 · see citing works
Mullassery, D., & Smith, N. P. (2015) · Seminars in Pediatric Surgery · doi:10.1053/j.sempedsurg.2015.01.011 · Cited by 79 · see citing works
Kunze, M., Klar, M., Morfeld, C., Thorns, B., Schild, R. L., Markfeld-Erol, F., Rasenack, R., Proempeler, H., Hentschel, R., & Schaefer, W. R. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.01.181 · Cited by 77 · see citing works
Szlachetko, J., Cotte, M., Morse, J., Salome-Pateyron, M., Jagodziński, P. P., Dousse, J.-C., Hoszowska, J., Kayser, Y., & Susini, J. (2010) · Journal of Synchrotron Radiation · doi:10.1107/s0909049510010691 · Cited by 69 · see citing works
Austin, C. A., Hinkley, G. K., Mishra, A., Zhang, Q., Umbreit, T. H., Betz, M. W., Wildt, B., Casey, B. J., Francke‐Carroll, S., Hussain, S. M., et al. (2015) · Nanotoxicology · doi:10.3109/17435390.2015.1107143 · Cited by 65 · see citing works
Saber, A. T., Jacobsen, N. R., Bornholdt, J., Kjær, S. L., Dybdahl, M., Risom, L., Loft, S. H., Vogel, U. B., & Wallin, H. (2006) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-3-4 · Cited by 62 · see citing works
Haberl, N., Hirn, S., Wenk, A., Diendorf, J., Epple, M., Johnston, B. D., Krombach, F., Kreyling, W. G., & Schleh, C. (2013) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.4.105 · Cited by 62 · see citing works
Effects of developmental exposure to silver in ionic and nanoparticle form: A study in rats
Charehsaz, M., Hougaard, K. S., Si̇pahi̇, H., Ekici, I. D., Kaspar, Ç., Çulha, M., Bucurgat, Ü. Ü., & Aydın, A. (2016) · DARU Journal of Pharmaceutical Sciences · doi:10.1186/s40199-016-0162-9 · Cited by 58 · see citing works
Wu, Z.-X., Hunter, D. D., Kish, V. L., Benders, K. M., Batchelor, T., & Dey, R. D. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0800511 · Cited by 56 · see citing works
Influence of Strain and Parity on the Risk of Litter Loss in Laboratory Mice
Weber, E. M., Algers, B., Würbel, H., Hultgren, J., & Olsson, I. A. S. (2012) · Reproduction in Domestic Animals · doi:10.1111/j.1439-0531.2012.02147.x · Cited by 52 · see citing works
Paul, G., Prado, Y., Dia, N., Rivière, É., Laurent, S., Roch, M., Elst, L. V., Müller, R. N., Sancey, L., Perriat, P., et al. (2014) · Chemical Communications · doi:10.1039/c4cc01251h · Cited by 48 · see citing works
Titanium oxide nanoparticle instillation induces inflammation and inhibits lung development in mice
Ambalavanan, N., Stanishevsky, A. V., Bulger, A., Halloran, B., Steele, C. H., Vohra, Y. K., & Matalon, S. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00013.2012 · Cited by 45 · see citing works
Roursgaard, M., Jensen, K. A., Poulsen, S. S., Jensen, N.-E. V., Poulsen, L. K., Hammer, M., Nielsen, G. D., & Larsen, S. T. (2011) · The Scientific World JOURNAL · doi:10.1100/tsw.2011.67 · Cited by 45 · see citing works
Roursgaard, M., Poulsen, S. S., Poulsen, L. K., Hammer, M., Jensen, K. A., Utsunomiya, S., Ewing, R. C., Balić-Žunić, T., Nielsen, G. D., & Larsen, S. T. (2010) · Human & Experimental Toxicology · doi:10.1177/0960327110363329 · Cited by 41 · see citing works
Franco‐Montoya, M., Waszak, P., Banalec, G., Levame, M., Lafuma, C., HARF, A., & Delacourt, C. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00140.2001 · Cited by 40 · see citing works
Self-citationIntrauterine Growth Restriction
Hay, W. W., Wong, R. J., & Stevenson, D. K. (2001) · Cambridge University Press eBooks · doi:10.1017/9781009418034.010 · Cited by 37 · see citing works
Présumé, M., Simon-Deckers, A., Tomkiewicz, C., Legrand, B., Nhieu, J. T. V., Beaune, G., Durupthy, O., Doucet, J., Coumoul, X., Pairon, J. ‐., et al. (2016) · Nanotoxicology · doi:10.1080/17435390.2016.1242797 · Cited by 32 · see citing works
Self-citationCombined Effects of in Utero and Adolescent Tobacco Smoke Exposure on Lung Function in C57Bl/6J Mice
Drummond, D., Baravalle-Einaudi, M., Lezmi, G., Vibhushan, S., Franco‐Montoya, M., Hadchouel, A., Boczkowski, J., & Delacourt, C. (2016) · Environmental Health Perspectives · doi:10.1289/ehp54 · Cited by 26 · see citing works
Self-citation[Morphometric studies on the growth of gas exchange capacity of the rat lung].
Weibel, E. R. (1966) · PubMed · Cited by 5 · see citing works
Intrauterine Growth Restriction
Hay, W. W., Thureen, P. J., & Anderson, M. S. (2001) · NeoReviews · doi:10.1542/neo.2-6-e129
Flagged first, then by citations
Cited by
Sorted by citations
Johnson, N. M., Hoffmann, A. R., Behlen, J. C., Lau, C., Pendleton, D., Harvey, N., Shore, R., Li, Y., Chen, J., Tian, Y., et al. (2021) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-021-00995-5 · Cited by 339 · see citing works
“[106] C57BL/6J mice TiO2, CeO2, Ag nanoparticles (10 nm diameter) 10 μL of NPs at 10 mg/mL Intratracheal GD2.”
BackgroundInfluentialLignelli, E., Palumbo, F., Myti, D., & Morty, R. E. (2019) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00369.2019 · Cited by 151 · see citing works
Recent insights on indirect mechanisms in developmental toxicity of nanomaterials
Dugershaw, B. B., Aengenheister, L., Hansen, S. S. K., Hougaard, K. S., & Buerki‐Thurnherr, T. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00359-x · Cited by 114 · see citing works
Gold nanoparticle distribution in advanced in vitro and ex vivo human placental barrier models
Aengenheister, L., Dietrich, D., Sadeghpour, A., Manser, P., Diener, L., Wichser, A., Kärst, U., Wick, P., & Buerki‐Thurnherr, T. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0406-6 · Cited by 71 · see citing works
Vidmar, J., Loeschner, K., Correia, M., Larsen, E. H., Manser, P., Wichser, A., Boodhia, K., Al-Ahmady, Z. S., Ruiz, J., Astruc, D., et al. (2018) · Nanoscale · doi:10.1039/c8nr02096e · Cited by 68 · see citing works
Fetotoxicity of Nanoparticles: Causes and Mechanisms
Teng, C., Jiang, C., Gao, S., Liu, X., & Zhai, S. (2021) · Nanomaterials · doi:10.3390/nano11030791 · Cited by 51 · see citing works
Vidmar, J., Buerki‐Thurnherr, T., & Loeschner, K. (2018) · Journal of Analytical Atomic Spectrometry · doi:10.1039/c7ja00402h · Cited by 49 · see citing works
Nelson, K., Hesse, B., Addison, O., Morrell, A. P., Groß, C., Lagrange, A., Suárez, V. T., Kohal, R., & Fretwurst, T. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c02416 · Cited by 50 · see citing works
Self-citationAdverse effects and underlying mechanism of rare earth elements
Wang, X., Wang, F., Yan, L., Gao, Z., Yang, S., Su, Z. G., Chen, W., Li, Y., & Wang, F. (2025) · Environmental Health · doi:10.1186/s12940-025-01178-3 · Cited by 49 · see citing works
Modulation of engineered nanomaterial interactions with organ barriers for enhanced drug transport
Lenders, V., Koutsoumpou, X., Phan, P., Soenen, S. J., Allegaert, K., Vleeschouwer, S. D., Toelen, J., Zhao, Z., & Manshian, B. B. (2023) · Chemical Society Reviews · doi:10.1039/d1cs00574j · Cited by 49 · see citing works
Wāng, Y., Han, Y., & Xu, D. (2023) · Environmental Science and Ecotechnology · doi:10.1016/j.ese.2023.100325 · Cited by 47 · see citing works
Wu, Y., Chen, L., Chen, F., Zou, H., & Wang, Z. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110911 · Cited by 46 · see citing works
Chortarea, S., Gupta, G. S., Saarimäki, L. A., Netkueakul, W., Manser, P., Aengenheister, L., Wichser, A., Fortino, V., Wick, P., Greco, D., et al. (2023) · Environment International · doi:10.1016/j.envint.2023.108015 · Cited by 42 · see citing works
Chen, B., Hong, W., Yang, P., Tang, Y., Zhao, Y., Aguilar, Z. P., & Xu, H. (2020) · Nanomaterials · doi:10.3390/nano10020259 · Cited by 42 · see citing works
Zhang, Y., Xu, B., Yao, M., Dong, T., Mao, Z., Hang, B., Han, X., Lin, Z., Bian, Q., Li, M., et al. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.09.015 · Cited by 41 · see citing works
On the developmental toxicity of silver nanoparticles
Zhang, J., Liu, S., Han, J., Wang, Z., & Zhang, S. (2021) · Materials & Design · doi:10.1016/j.matdes.2021.109611 · Cited by 40 · see citing works
N6-methyladenosine mediates Nrf2 protein expression involved in PM2.5-induced pulmonary fibrosis
Ji, D., Hu, C., Ning, J., Ying, X., Zhang, H., Zhang, B., Liu, B., Liu, Q., Ji, W., & Zhang, R. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114755 · Cited by 37 · see citing works
Mao, Z., Yao, M., Li, Y., Fu, Z., Li, S., Zhang, L., Zhou, Z., Tang, Q., Han, X., & Xia, Y. (2018) · Biomaterials Science · doi:10.1039/c8bm00856f · Cited by 34 · see citing works
Zhong, H., Geng, Y., Chen, J., Gao, R., Yu, C., Yang, Z., Chen, X., Mu, X., Liu, X., & He, J. (2019) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2019.121830 · Cited by 34 · see citing works
Developmental Toxicity of Nanomaterials: Need for a Better Understanding of Indirect Effects
Buerki‐Thurnherr, T., Schaepper, K., Aengenheister, L., & Wick, P. (2018) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.8b00177 · Cited by 33 · see citing works
Sex difference in bronchopulmonary dysplasia of offspring in response to maternal PM2.5 exposure
Yue, H., Ji, X., Ku, T., Li, G., & Sang, N. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.122033 · Cited by 30 · see citing works
Nedder, M., Boland, S., Devineau, S., Zerrad-Saadi, A., Rogozarski, J., Lai–Kuen, R., Baya, I., Guibourdenche, J., Vibert, F., Chissey, A., et al. (2020) · Nanomaterials · doi:10.3390/nano10071309 · Cited by 33 · see citing works
On Placental Toxicology Studies and Cerium Dioxide Nanoparticles
Deval, G., Boland, S., Fournier, T., & Ferecatu, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212266 · Cited by 28 · see citing works
Zhang, H., Chen, R., Shao, Y. W., Wang, H., & Liu, Z. (2018) · Toxicology Research · doi:10.1039/c8tx00032h · Cited by 26 · see citing works
Chronic maternal exposure to titanium dioxide nanoparticles alters breathing in newborn offspring
Colnot, É., Cardoit, L., Cabirol, M.-J., Roudier, L., Delville, M., Fayoux, A., Thoby‐Brisson, M., Juvin, L., & Morin, D. (2022) · Particle and Fibre Toxicology · doi:10.1186/s12989-022-00497-4 · Cited by 26 · see citing works
Macrophage autophagy protects mice from cerium oxide nanoparticle-induced lung fibrosis
Annangi, B., Lu, Z., Bruniaux, J., Ridoux, A., da Silva, V. M., Vantelon, D., Boczkowski, J., & Lanone, S. (2021) · Particle and Fibre Toxicology · doi:10.1186/s12989-021-00398-y · Cited by 24 · see citing works
Self-citationD’Errico, J. N., Doherty, C., Fournier, S., Renkel, N., Kallontzi, S., Goedken, M. J., Fabris, L., Buckley, B., & Stapleton, P. A. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109148 · Cited by 22 · see citing works
Dugershaw, B. B., Bossart, J., Buljan, M., Hannig, Y., Zehnder, S., Gupta, G. S., Kissling, V. M., Nowak-Sliwinska, P. M., B, J. R. V. B., Griffioen, A. W., et al. (2024) · Advanced Science · doi:10.1002/advs.202401060 · Cited by 21 · see citing works
Zhang, Y., Wu, J., Feng, X., Wang, R., Chen, A., & Shao, L. (2017) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2018.1397131 · Cited by 21 · see citing works
Kucki, M., Aengenheister, L., Diener, L., Rippl, A., Vranic, S., Newman, L., Vázquez, E., Kostarelos, K., Wick, P., & Buerki‐Thurnherr, T. (2018) · 2D Materials · doi:10.1088/2053-1583/aab9e2 · Cited by 18 · see citing works
Evaluation of the cytotoxic effect of titanium dioxide nanoparticles in human embryonic lung cells
AFŞAR, O., & Oltulu, Ç. (2023) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.55730/1300-0144.5733 · Cited by 17 · see citing works
Effects of maternal−fetal transmission of viruses and other environmental agents on lung development
Piedimonte, G., & Harford, T. J. (2019) · Pediatric Research · doi:10.1038/s41390-019-0657-4 · Cited by 17 · see citing works
Freyre‐Fonseca, V., Medina‐Reyes, E. I., Téllez‐Medina, D. I., Paniagua‐Contreras, G. L., Monroy‐Pérez, E., Vaca‐Paniagua, F., Delgado‐Buenrostro, N. L., Flores–Flores, J. O., López‐Villegas, E. O., Gutiérrez‐López, G. F., et al. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.11.049 · Cited by 14 · see citing works
Barjat, T. R., Prieux, C., Leclerc, L., Sarry, G., Grimal, L., Chauleur, C., Pourchez, J., & Forest, V. (2020) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2020.126477 · Cited by 11 · see citing works
Lacconi, V., Massimiani, M., Paglione, L., Messina, A., Battistini, B., Filippis, P. D., Magrini, A., Pietroiusti, A., & Campagnolo, L. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.116056 · Cited by 11 · see citing works
POLLURISK: AN INNOVATIVE EXPERIMENTAL PLATFORM TO INVESTIGATE HEALTH IMPACTS OF AIR QUALITY
Coll, P., Cazaunau, M., Boczkowski, J., Zysman, M., Doussin, J., Gratien, A., Dérumeaux, G., Pini, M., Biagio, C. D., Pangui, E., et al. (2018) · WIT transactions on ecology and the environment · doi:10.2495/air180521 · Cited by 11 · see citing works
Self-citationMao, Z., Guan, Y., Li, T., Zhang, L., Liu, M., Xing, B., Yao, M., & Chen, M. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109125 · Cited by 11 · see citing works
Lai, K. P., Li, J., Chan, T., Chen, A., Lee, Y. L., Yeung, W. S. B., & Wong, C. K. C. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.05.058 · Cited by 10 · see citing works
Placental transfer and hazards of silver nanoparticles exposure during pregnancy: a review
Han, Y., Li, C., & Wāng, Y. (2024) · Environmental Chemistry Letters · doi:10.1007/s10311-024-01709-3 · Cited by 8 · see citing works
Lin, M. S., Yan, L., Wang, X., Wang, Y., Zhou, Y., Wang, Y., & Tian, C. (2024) · Environmental Research · doi:10.1016/j.envres.2024.119165 · Cited by 6 · see citing works
Human Health Implications of Environmental Nanoparticles
Isibor, P. O., Oyegbade, S. A., Oni, G. J., Wurie, A. W., Abiodun, E. O., Sani, A. R., & Oyewole, O. A. (2024) · Springer eBooks · doi:10.1007/978-3-031-54154-4_12 · Cited by 5 · see citing works
Zhou, W., Zhang, W., Fu, Z., Tang, C., Chen, P., Huang, R., Yang, C., Chen, S., Zuo, Z., He, C., et al. (2024) · Journal of Environmental Sciences · doi:10.1016/j.jes.2024.10.009 · Cited by 4 · see citing works
Boulain, M., Morin, D., & Juvin, L. (2024) · Discover Nano · doi:10.1186/s11671-023-03927-0 · Cited by 4 · see citing works
Gianoncelli, A., Cammisuli, F., Altissimo, M., Salome-Pateyron, M., Radillo, O., Ricci, G., Giordani, S., Rizzardi, C., & Pascolo, L. (2018) · X-Ray Spectrometry · doi:10.1002/xrs.2994 · Cited by 4 · see citing works
Prenatal Origins of Obstructive Airway Disease: Starting on the Wrong Trajectory?
Wang, K. C. W., James, A. L., Donovan, G. M., & Noble, P. B. (2024) · Comprehensive physiology · doi:10.1002/j.2040-4603.2024.tb00804.x · Cited by 3 · see citing works
Nanotechnology-Enhanced Imaging: Advancing Precision in Fetal Anomaly Detection
Acharya, B., Behera, A., Sahu, P. K., Behera, S., & Prajapati, B. G. (2025) · Biomedical Materials & Devices · doi:10.1007/s44174-025-00364-8 · Cited by 3 · see citing works
Mechanistic paradigms of teratogenicity induced by metallic nanoparticles—a mini review
Singh, M., Verma, Y., & Rana, S. V. S. (2025) · BioMetals · doi:10.1007/s10534-025-00781-8 · Cited by 2 · see citing works
Yokota, S., Kawakami, T., Yoshioka, H., Moriya, N., Sekine, N., Miura, N., Kitajima, S., Ichinose, T., & Oshio, S. (2025) · Environmental Science and Pollution Research · doi:10.1007/s11356-025-36607-w · Cited by 2 · see citing works
Wang, Z., Li, Y., Fan, X., Fan, W., Wang, Y., Liang, D., & Dong, Z. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.140235 · Cited by 1 · see citing works
生物多様性・里山の研究動向から考える人間-自然系の環境社会学(研究動向)
松村, 正., & 香坂, 玲. (2010) · 環境社会学研究 · Cited by 1 · see citing works
Chen, F., Wang, C., Yue, L., Tang, J., Du, H., Wu, Y., Schröder, P., Wang, Z., & Xing, B. (2022) · Environmental Science Nano · doi:10.1039/d1en01126j · Cited by 1 · see citing works
Deval, G., Mawas, S., Devineau, S., Borderie, D., Mikolajczak, C., Lefèvre, G., Bui, L. C., Renault, J., Izabelle, C., Fournier, T., et al. (2025) · Journal of Hazardous Materials Advances · doi:10.1016/j.hazadv.2025.100802 · Cited by 1 · see citing works
Price, E. (2019) · Journal of International Crisis and Risk Communication Research
Developmental toxicity of engineered nanomaterials
Campagnolo, L., Möller, P., Jacobsen, N. R., & Hougaard, K. S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89773-0.00016-3
Nanoparticles and pregnancy: from benchside to the community
Roncati, L. (2022) · Clinical and Experimental Obstetrics & Gynecology · doi:10.31083/j.ceog4905104
Enaud, R. (2023) · Perfectionnement en Pédiatrie · doi:10.1016/s2588-932x(23)00150-x
Prenatal Origins of Obstructive Airway Disease: Starting on the Wrong Trajectory?
Wang, K. C. W., James, A. L., Donovan, G. M., & Noble, P. B. (2024) · Comprehensive physiology · doi:10.1002/cphy.c230019 · Cited by 4 · see citing works
Boulain, M., Morin, D., & Juvin, L. (2024) · Figshare · doi:10.6084/m9.figshare.26671692
Boulain, M., Morin, D., & Juvin, L. (2024) · Figshare · doi:10.6084/m9.figshare.26671710
Boulain, M., Morin, D., & Juvin, L. (2024) · Figshare · doi:10.6084/m9.figshare.26671698
Boulain, M., Morin, D., & Juvin, L. (2024) · Figshare · doi:10.6084/m9.figshare.26671701
Boulain, M., Morin, D., & Juvin, L. (2024) · Figshare · doi:10.6084/m9.figshare.26671707
Boulain, M., Morin, D., & Juvin, L. (2024) · Figshare · doi:10.6084/m9.figshare.26671695
Boulain, M., Morin, D., & Juvin, L. (2024) · Figshare · doi:10.6084/m9.figshare.26671704
Johnson, N. M., Hoffmann, A. R., Behlen, J. C., Lau, C. H., Pendleton, D., Harvey, N., Shore, R. A., Li, Y., Chen, J., Tian, Y., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14966363
Deweirdt, J., Charles, S., Jomini, S., Rana, P., Aurélie, N., & Michel-Caillet, C. (2026) · Nanotoxicology · doi:10.1080/17435390.2025.2608953
Human placental exposure to pollutant nanoparticles: uptake, translocation and functional impact
Bethell, K., Povey, A. C., Johnstone, E., & Ruane, P. T. (2026) · The Journal of Physiology · doi:10.1113/jp289591
Wu, S., Xu, Q., Zhuang, W., Gu, X., Chen, Y., Chen, Q., Liu, Y., Li, M., Lin, L., Cai, L., et al. (2026) · Toxics · doi:10.3390/toxics14080653
Skonieczna, B., Nazarko, N., Godlewska, E., Wasiluk, N., Czech, E. K., Wilczewska, A. Z., Regulska, E., Car, H., & Niemirowicz-Laskowska, K. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04801-8
- Authors
- Paul, E., Franco-Montoya, M.-L., Paineau, E., Angeletti, B., Vibhushan, S., Ridoux, A., Tiendrebeogo, A., Salome, M., Hesse, B., Vantelon, D., Rose, J., Canouï-Poitrine, F., Boczkowski, J., Lanone, S., Delacourt, C., & Pairon, J.-C.
- Affiliations
- Inserm (FR)
- Inserm U955, Equipe 04, Créteil, France;
- Laboratoire de Physique des Solides, CNRS, University of Paris-Sud, Université Paris-Saclay, Orsay, France;
- Centre National de la Recherche Scientifique (FR)
- European Synchrotron Radiation Facility, Grenoble, France;
- European Synchrotron Radiation Facility (FR)
- Synchrotron SOLEIL (FR)
- DHU A-TVB, IMRB, EA 7376 CEpiA (Clinical Epidemiology And Ageing Unit), Université Paris-Est Créteil (UPEC), Créteil, France;
- Corresponding author
- Pairon, Jean-Claude
- ORCID
- Venue
- Nanotoxicology
- Publisher
- Informa UK Limited
- Published
- 2017-04-17
- Volume
- 11
- Issue
- 4
- Pages
- 484-495
- ISSN
- 1743-5390 (ISSN-L)
- 1743-5404
- OpenAlex
- W2597698418
- Cited by
- 72
- References
- 53
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 15 · 2023: 7 · 2022: 5 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 12 · 2017: 2
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- green
- inserm.hal.science
- Licence
- other-oa
- Locations
- Nanotoxicology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- HAL (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-11-IDEX-0001-02,ANR-11-LABX-0064)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Keywords
- metal nanoparticles, metal oxide nanoparticles, prenatal exposure, lung development, titanium dioxide, cerium oxide, silver nanoparticles, placental transfer, alveolarization, lung maturation, VEGFα, MMP-9, FGF18, placental efficiency, developmental toxicity
- MeSH terms
- Air Pollutants, Animals, Cerium, Female, Fibroblast Growth Factors, Lung, Male, Mice, Inbred C57BL, Placenta, Pregnancy, Prenatal Exposure Delayed Effects, Silver, Titanium, Maternal Exposure, Inhalation Exposure, Organogenesis, Vascular Endothelial Growth Factor A, Mice, Metal Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
