Intermittent parathyroid hormone (1–34) enhances mechanical strength and density of new bone after distraction osteogenesis in rats
Open accessAbstract
Distraction osteogenesis is used both for leg lengthening and for bone transportation in the treatment of fractures and nonunions. The main problem with this method is that the time until full recovery may be up to a year, partly because of the time needed for the new formed bone to consolidate and become strong enough for weight bearing. We have studied whether intermittent parathyroid hormone (PTH(1-34)) could accelerate the consolidation of new formed bone after distraction osteogenesis in rats. Forty-seven, 3-months-old male Sprague-Dawley rats underwent lengthening of the right femur using an external fixator. After a middiaphyseal osteotomy and a 7-day latency period, the callus was distracted during 10 days, with a distraction rate of 0.25 mm twice a day. The consolidation time was either 20 days or 40 days after distraction was completed. A dose of 60 microg of human PTH(1-34)/kg body weight/injection or vehicle was given every second day beginning 30 days before the rats were killed. Both femura of each rat were subjected to mechanical testing and dual-energy X-ray absorptiometry. Blinded histological examination was done for the distracted femura. In the 20 days consolidation experiment, PTH(1-34) increased ultimate load (56%), stiffness (117%), total regenerate callus volume (58%), callus BMC (24%) and histologic bone density (35%) compared to untreated distraction osteogenesis specimens. In the 40 days consolidation experiment, PTH(1-34) increased ultimate load (54%), stiffness (55%), callus BMC (33%) and histologic bone density (23%) compared to untreated distraction osteogenesis specimens. Total regenerate callus volume was unchanged. The contralateral femur also became stronger, stiffer and denser under PTH(1-34) treatment, but to a lesser degree. PTH(1-34) might become useful to shorten the consolidation time after distraction osteogenesis in humans.
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PTH had no effect on the chondroid phase of fracture healing, but an effect was observed once bridging bone developed.
“PTH had no effect on the chondroid phase of fracture healing, but an effect was observed once bridging bone developed (106).”
From Methods to accelerate fracture healing – a narrative review from a clinical perspective (2024) · cites this paper as [106]
The Results (page not available) report that PTH increased the strength and density of newly formed bone during consolidation after distraction osteogenesis in rats. The paper does not report a comparison of PTH effects during a chondroid phase and after bridging bone developed, so it does not support the claimed timing or the assertion of no chondroid-phase effect. (LLM, conf=0.78)
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Hildreth, B. E., Williams, M. M., Dembek, K. A., Hernon, K. M., Rosol, T. J., & Toribio, R. E. (2015) · Transgenic Research · doi:10.1007/s11248-015-9901-9
Kapoor, A., Mittal, N., Patil, B. M., Kansay, R., Gupta, S., & Sharma, A. (2020) · Strategies in Trauma and Limb Reconstruction · doi:10.5005/jp-journals-10080-1464
The Role of Parathyroid Hormone in Fracture Healing
Giacomo, A. F. D., & Einhorn, T. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397166-1.00062-x
- Authors
- Seebach, C., Skripitz, R., Andreassen, T. T., & Aspenberg, P.
- Affiliations
- Orthopaedic University Hospital Friedrichsheim (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Aarhus University (DK)
- Linköping University (SE)
- Corresponding author
- Aspenberg, P.
- ORCID
- Seebach, C.
- Venue
- Journal of Orthopaedic Research®
- Publisher
- Wiley
- Published
- 2004-05
- Volume
- 22
- Issue
- 3
- Pages
- 472-478
- ISSN
- 0736-0266 (ISSN-L)
- 1554-527X
- OpenAlex
- W2000965617
- Cited by
- 77
- References
- 18
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 5 · 2019: 7 · 2018: 3 · 2016: 2 · 2015: 7 · 2014: 3 · 2013: 3 · 2012: 6
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Orthopaedic Research® (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Epidemiology › Bone fractures and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Craniofacial Disorders and Treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- parathyroid hormone (1-34), distraction osteogenesis, bone consolidation, mechanical strength, bone mineral density, callus, bone transport, ultimate load, stiffness, bone mineral content
- MeSH terms
- Animals, Biomechanical Phenomena, Bone Regeneration, Male, Parathyroid Hormone, Peptide Fragments, Bone Density, Osteogenesis, Distraction, Rats
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