Helicobacter pylori PqqE is a new virulence factor that cleaves junctional adhesion molecule A and disrupts gastric epithelial integrity
Open accessAbstract
Helicobacter pylori infects approximately half of the world’s population and is the strongest risk factor for peptic ulcer disease and gastric cancer, representing a major global health concern. H. pylori persistently colonizes the gastric epithelium, where it subverts the highly organized structures that maintain epithelial integrity. Here, a unique strategy used by H. pylori to disrupt the gastric epithelial junctional adhesion molecule-A (JAM-A) is disclosed, using various experimental models that include gastric cell lines, primary human gastric cells, and biopsy specimens of infected and non-infected individuals. H. pylori preferentially cleaves the cytoplasmic domain of JAM-A at Alanine 285. Cells stably transfected with full-length JAM-A or JAM-A lacking the cleaved sequence are used in a range of functional assays, which demonstrate that the H. pylori cleaved region is critical to the maintenance of the epithelial barrier and of cell-cell adhesion. Notably, by combining chromatography techniques and mass spectrometry, PqqE (HP1012) is purified and identified as the H. pylori virulence factor that cleaves JAM-A, uncovering a previously unreported function for this bacterial protease. These findings propose a novel mechanism for H. pylori to disrupt epithelial integrity and functions, breaking new ground in the understanding of the pathogenesis of this highly prevalent and clinically relevant infection.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The zinc-protease PqqE and the serine-protease HtrA disrupt gastric mucosal integrity and thereby facilitate bacterial invasion.
“the zinc-protease PqqE and the serine-protease HtrA disrupt gastric mucosal integrity61–63 and thereby facilitate bacterial invasion.”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [61]
Tight junctions are targets of infectious agents such as Pseudomonas aeruginosa (through LasB), H. pylori (PqqE and HtrA), C. jejuni (HtrA), V. cholerae (vibrolysin), Shigella, Salmonella or pathogenic Escherichia coli (SepA).
“Tight junctions are also targets of infectious agents such as Pseudomonas aeruginosa (through LasB),132 H. pylori (PqqE and HtrA),61–63 C. jejuni (HtrA), 79,80 V. cholerae (vibrolysin),10,83 Shigella, Salmonella or pathogenic Escherichia coli (SepA).72,133”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [61]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Classification and Grading of Gastritis: The Updated Sydney System
Dixon, M. F., Genta, R. M., Yardley, J. H., & Correa, P. (1996) · The American Journal of Surgical Pathology · doi:10.1097/00000478-199610000-00001 · Cited by 5,185 · see citing works
Multifunctional strands in tight junctions
Tsukita, S., Furuse, M., & Itoh, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35067088 · Cited by 2,514 · see citing works
Rawlings, N. D., Barrett, A. J., Thomas, P. D., Huang, X., Bateman, A., & Finn, R. D. (2018) · Nucleic Acids Research · doi:10.1093/nar/gkx1134 · Cited by 1,749 · see citing works
Tight junctions: from simple barriers to multifunctional molecular gates
Zihni, C., Mills, C., Matter, K., & Balda, M. S. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.80 · Cited by 1,484 · see citing works
Martín-Padura, I., Lostaglio, S., Schneemann, M., Williams, L., Romano, M., Fruscella, P., Panzeri, C., Stoppacciaro, A., Ruco, L., Villa, A., et al. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.1.117 · Cited by 1,387 · see citing works
Disruption of the Epithelial Apical-Junctional Complex by Helicobacter pylori CagA
Amieva, M. R., Vogelmann, R., Covacci, A., Tompkins, L. S., Nelson, W. J., & Falkow, S. (2003) · Science · doi:10.1126/science.1081919 · Cited by 739 · see citing works
Helicobacter pylori in Health and Disease
Cover, T. L., & Blaser, M. J. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.073 · Cited by 716 · see citing works
JAM-A regulates permeability and inflammation in the intestine in vivo
Laukoetter, M. G., Nava, P., Lee, W. Y., Severson, E. A., Capaldo, C., Babbin, B. A., Williams, I. R., Koval, M. H., Peatman, E., Campbell, J. A., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071416 · Cited by 512 · see citing works
Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity
Saadat, I., Higashi, H., Obuse, C., Umeda, M., Murata‐Kamiya, N., Saito, Y., Lu, H., Ohnishi, N., Azuma, T., Suzuki, A., et al. (2007) · Nature · doi:10.1038/nature05765 · Cited by 501 · see citing works
Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells
Kaparakis‐Liaskos, M., Turnbull, L., Carneiro, L. A. M., Firth, S. D., Coleman, H. A., Parkington, H. C., Bourhis, L. L., Karrar, A., Viala, J., Mak, J., et al. (2009) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01404.x · Cited by 455 · see citing works
Junctional Adhesion Molecule Interacts with the PDZ Domain-containing Proteins AF-6 and ZO-1
Ebnet, K., Schulz, C. U., zu Brickwedde, M.-K. M., Pendl, G. G., & Vestweber, D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002363200 · Cited by 437 · see citing works
Tight junctions as targets of infectious agents
Guttman, J. A., & Finlay, B. B. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.10.028 · Cited by 398 · see citing works
The cell polarity protein ASIP/PAR‐3 directly associates with junctional adhesion molecule (JAM)
Ebnet, K., Suzuki, A., Horikoshi, Y., Hirose, T., zu Brickwedde, M. M., Ohno, S., & Vestweber, D. (2001) · The EMBO Journal · doi:10.1093/emboj/20.14.3738 · Cited by 394 · see citing works
Global Transposon Mutagenesis and Essential Gene Analysis of Helicobacter pylori
Salama, N. R., Shepherd, B., & Falkow, S. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.23.7926-7935.2004 · Cited by 309 · see citing works
Hoy, B., Löwer, M., Weydig, C., Carra, G., Tegtmeyer, N., Geppert, T., Schröder, P., Sewald, N., Backert, S., Schneider, G., et al. (2010) · The EMBO Reports · doi:10.1038/embor.2010.114 · Cited by 295 · see citing works
Vetrano, S., Rescigno, M., Cera, M. R., Correale, C., Rumio, C., Doni, A., Fantini, M. C., Sturm, A., Borroni, E. M., Repici, A., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.002 · Cited by 254 · see citing works
Necchi, V., Candusso, M. E., Tava, F., Luinetti, O., Ventura, U., Fiocca, R., Ricci, V., & Solcia, E. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.01.049 · Cited by 243 · see citing works
Mandell, K. J., Babbin, B. A., Nusrat, A., & Parkos, C. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412650200 · Cited by 198 · see citing works
Wroblewski, L. E., Shen, L., Ogden, S., Romero–Gallo, J., Lapierre, L. A., Israel, D. A., Turner, J. R., & Peek, R. M. (2009) · Gastroenterology · doi:10.1053/j.gastro.2008.10.011 · Cited by 193 · see citing works
Ebnet, K. (2017) · Physiological Reviews · doi:10.1152/physrev.00004.2017 · Cited by 177 · see citing works
Severson, E. A., Lee, W. Y., Capaldo, C., Nusrat, A., & Parkos, C. A. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-10-1014 · Cited by 175 · see citing works
Helicobacter pylori Employs a Unique Basolateral Type IV Secretion Mechanism for CagA Delivery
Tegtmeyer, N., Wessler, S., Necchi, V., Rohde, M., Harrer, A., Rau, T. T., Asche, C. I., Boehm, M., Loessner, H., Figueiredo, C., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.09.005 · Cited by 156 · see citing works
Self-citationHelicobacter pylori Usurps Cell Polarity to Turn the Cell Surface into a Replicative Niche
Tan, S., Tompkins, L. S., & Amieva, M. R. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000407 · Cited by 152 · see citing works
Naik, M. U., Naik, T. U., Suckow, A. T., Duncan, M. K., & Naik, U. P. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-3057 · Cited by 149 · see citing works
Wroblewski, L. E., Piazuelo, M. B., Chaturvedi, R., Schumacher, M., Aihara, E., Feng, R., Noto, J. M., Delgado, A., Israel, D. A., Zavros, Y., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307650 · Cited by 143 · see citing works
Bugaytsova, J. A., Björnham, O., Chernov, Y. A., Gideonsson, P., Henriksson, S., Méndez, M., Sjöström, R., Mahdavi, J., Shevtsova, A. A., Ilver, D., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.02.013 · Cited by 136 · see citing works
Fedwick, J. P., Lapointe, T. K., Meddings, J. B., Sherman, P. M., & Buret, A. G. (2005) · Infection and Immunity · doi:10.1128/iai.73.12.7844-7852.2005 · Cited by 129 · see citing works
Monteiro, A. C., Sumagin, R., Rankin, C. R., Leoni, G., Mina, M. J., Reiter, D. M., Stehle, T., Dermody, T. S., Schaefer, S. A., Hall, R. A., et al. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-06-0298 · Cited by 129 · see citing works
aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation
Iden, S., Misselwitz, S., Peddibhotla, S. S. D., Tuncay, H., Rehder, D., Gerke, V., Robenek, H., Suzuki, A., & Ebnet, K. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201104143 · Cited by 111 · see citing works
Oliveira, M. J., Costa, A. M., Costa, A. C., Ferreira, R. M., Sampaio, P., Machado, J. C., Seruca, R., Mareel, M., & Figueiredo, C. (2009) · The Journal of Infectious Diseases · doi:10.1086/604727 · Cited by 95 · see citing works
Self-citationMullaney, E., Brown, P. A., Smith, S. M., Botting, C. H., Yamaoka, Y., Terres, A. M., Kelleher, D. P., & Windle, H. J. (2009) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200800192 · Cited by 91 · see citing works
Figueiredo, J., Söderberg, O., Simões‐Correia, J., Grannas, K., Suriano, G., & Seruca, R. (2012) · European Journal of Human Genetics · doi:10.1038/ejhg.2012.159 · Cited by 90 · see citing works
Bebb, J. R., Letley, D. P., Thomas, R. J., Aviles, F., Collins, H. M., Watson, S. A., Hand, N. M., Zaitoun, A., & Atherton, J. C. (2003) · Gut · doi:10.1136/gut.52.10.1408 · Cited by 88 · see citing works
Löwer, M., Weydig, C., Metzler, D., Reuter, A., Starzinski‐Powitz, A., Weßler, S., & Schneider, G. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003510 · Cited by 84 · see citing works
Magalhães, A., Marcos‐Pinto, R., Nairn, A. V., Rosa, M. D., Ferreira, R. M., Junqueira-Neto, S., Freitas, D. P., Gomes, J., Oliveira, P., Santos, M., et al. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.07.001 · Cited by 82 · see citing works
Self-citationOlofsson, A., Skalman, L. N., Obi, I. R., Lundmark, R., & Arnqvist, A. (2014) · mBio · doi:10.1128/mbio.00979-14 · Cited by 79 · see citing works
Glycoproteomic Analysis of Serum from Patients with Gastric Precancerous Lesions
Gomes, C., Almeida, A., Ferreira, J. A., Silva, L., Sousa, H. S., Pinto-de-Sousa, J., Santos, L. L., Amado, F. M. L., Schwientek, T., Levery, S. B., et al. (2013) · Journal of Proteome Research · doi:10.1021/pr301112x · Cited by 69 · see citing works
Self-citationTurkina, M. V., Olofsson, A., Magnusson, K., Arnqvist, A., & Vikström, E. (2015) · FEMS Microbiology Letters · doi:10.1093/femsle/fnv076 · Cited by 66 · see citing works
Costa, Â. M., Ferreira, R. M., Pinto-Ribeiro, I., Sougleri, I. S., Oliveira, M. J., Carreto, L. C., Santos, M. A. S., Sgouras, D. N., Carneiro, F., Leite, M., et al. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw031 · Cited by 53 · see citing works
Self-citationSuzuki, K., Kokai, Y., Sawada, N., Takakuwa, R., Kuwahara, K., Isogai, E., Isogai, H., & Mori, M. (2001) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s004280100430 · Cited by 41 · see citing works
Crystal and Solution Structures of a Prokaryotic M16B Peptidase: an Open and Shut Case
Aleshin, A. E., Gramatikova, S. I., Hura, G. L., Bobkov, A. A., Strongin, A. Y., Stec, B., Tainer, J. A., Liddington, R., & Smith, J. W. (2009) · Structure · doi:10.1016/j.str.2009.09.009 · Cited by 38 · see citing works
Direct analysis of the extracellular proteome from two strains of Helicobacter pylori
Smith, T. G., Lim, J., Weinberg, M. V., Wells, L., & Hoover, T. R. (2007) · PROTEOMICS · doi:10.1002/pmic.200600875 · Cited by 37 · see citing works
Asymptomatic Helicobacter pylori Gastritis Is Associated with Increased Sucrose Permeability
Borch, K., Sjostedt, C., Hannestad, U., Söderholm, J. D., Franzén, L., & Mårdh, S. (1998) · Digestive Diseases and Sciences · doi:10.1023/a:1018809913230 · Cited by 35 · see citing works
Decrease in Gastric Permeability to Sucrose Following Cure of Helicobacter pylori Infection
Goodgame, R., Malaty, H. M., El‐Zimaity, H. M. T., & Graham, D. Y. (1997) · Helicobacter · doi:10.1111/j.1523-5378.1997.tb00057.x · Cited by 33 · see citing works
Marques, M. S., Melo, J., Cavadas, B., Mendes, N. M., Pereira, L., Carneiro, F., Figueiredo, C., & Leite, M. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02712 · Cited by 32 · see citing works
Self-citationKorsak, B., Almeida, G. M., Rocha, S., Pereira, C. S. M., Mendes, N. M., Osório, H., Pereira, P. M. R., Rodrigues, J. M. M., Schneider, R. J., Sarmento, B. F. C. C., et al. (2017) · International Journal of Cancer · doi:10.1002/ijc.30844 · Cited by 29 · see citing works
Self-citationGrowth phase-dependent composition of the Helicobacter pylori exoproteome
Snider, C. A., Voss, B. J., McDonald, W. H., & Cover, T. L. (2015) · Journal of Proteomics · doi:10.1016/j.jprot.2015.08.025 · Cited by 26 · see citing works
Heterosubunit Composition and Crystal Structures of a Novel Bacterial M16B Metallopeptidase
Maruyama, Y., Chuma, A., Mikami, B., Hashimoto, W., & Murata, K. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.01.038 · Cited by 25 · see citing works
Sun, Y., Söderholm, J. D., Petersson, F., & Borch, K. (2004) · Helicobacter · doi:10.1111/j.1083-4389.2004.00227.x · Cited by 23 · see citing works
Mass Spectrometry Methods for Studying Glycosylation in Cancer
Osório, H., & Reis, C. A. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-392-3_13 · Cited by 19 · see citing works
Self-citationNardilysin Cleaves Peptides at Monobasic Sites
Chow, K. M., Oakley, O. R., Goodman, J. P., Ma, Z., Juliano, M. A., Juliano, L., & Hersh, L. B. (2003) · Biochemistry · doi:10.1021/bi027178d · Cited by 19 · see citing works
Leite, M. F., & Figueiredo, C. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-005-2_9 · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Nabavi-Rad, A., Sadeghi, A., Aghdaei, H. A., Yadegar, A., Smith, S. M., & Zali, M. R. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2108655 · Cited by 141 · see citing works
The emerging roles of bacterial proteases in intestinal diseases
Caminero, A., Guzman, M., Libertucci, J., & Lomax, A. E. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2181922 · Cited by 92 · see citing works
The impacts of probiotics in eradication therapy of Helicobacter pylori
Bai, X., Zhu, M., He, Y., Wang, T., Tian, D., & Shu, J.-C. (2022) · Archives of Microbiology · doi:10.1007/s00203-022-03314-w · Cited by 58 · see citing works
Histopathological Features of Helicobacter pylori Infection in Gastric Mucosa
Wang, Y., Li, C., Zhou, Y., Zeng, L., Li, Y., Huang, S.-L., Zhu, C.-Y., Wang, Y., Wang, S., & Chen, X.-D. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s383075 · Cited by 22 · see citing works
Proteolytic Landscapes in Gastric Pathology and Cancerogenesis
Bernegger, S., Jarząb, M., Weßler, S., & Posselt, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052419 · Cited by 16 · see citing works
Evolution and Role of Proteases in Campylobacter jejuni Lifestyle and Pathogenesis
Linz, B., Sharafutdinov, I., Tegtmeyer, N., & Backert, S. (2023) · Biomolecules · doi:10.3390/biom13020323 · Cited by 16 · see citing works
Naumann, M., Ferino, L., Sharafutdinov, I., & Backert, S. (2023) · Current topics in microbiology and immunology · doi:10.1007/978-3-031-47331-9_8 · Cited by 14 · see citing works
Wang, S., Yang, H., Zhang, W., Li, Z., & Ji, R. (2024) · Helicobacter · doi:10.1111/hel.13065 · Cited by 12 · see citing works
Sukkasam, N., Incharoensakdi, A., & Monshupanee, T. (2022) · Plant and Cell Physiology · doi:10.1093/pcp/pcac100 · Cited by 10 · see citing works
Role of lncRNAs in Helicobacter pylori and Epstein-Barr virus associated gastric cancers
Mostaghimi, T., Bahadoran, E., Bakht, M., Taheri, S., Sadeghi, H., & Babaei, A. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122316 · Cited by 9 · see citing works
Qian, J., Li, Z., Wang, J., Lin, Y., & Yu, Y. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1451563 · Cited by 7 · see citing works
Bacterial Proteases in Helicobacter pylori Infections and Gastric Disease
Weßler, S., & Posselt, G. (2023) · Current topics in microbiology and immunology · doi:10.1007/978-3-031-47331-9_10 · Cited by 7 · see citing works
Zhang, L., Yu, F., Zhang, Y., & Li, P. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1392129 · Cited by 4 · see citing works
Yan, Y., Dong, L., Xu, J., Zhang, Z., Jia, P., Zhang, J., Chen, W., & Gao, W. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1487978 · Cited by 3 · see citing works
Puca, V., Marinacci, B., Pagotto, S., Krzyżek, P., Cintio, F. D., Pellegrini, B., Pietrangelo, L., Ronci, M., & Grande, R. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1765988 · Cited by 1 · see citing works
Zarzecka, U., Repetto, O., Ambroziak, P., Bielecka, M., Czaplewska, P., Mruk, I., Musiał, N., Figaj, D., Roncarati, D., Diechler, S., et al. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107979 · Cited by 1 · see citing works
Shankar, U. N., Shiraz, M., Kumar, P., & Akif, M. (2024) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.2596
Jarząb, M., & Skórko‐Glonek, J. (2025) · Biomolecules · doi:10.3390/biom15121697
A novel corrected anion gap links metabolic acid attack to peptic ulcer disease
Lin, X.-P., & Lin, S.-X. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1758803
Jarząb, M., Wadhwa, S., Ferner, C. D., Diechler, S., Posselt, G., & Weßler, S. (2026) · Microbial Physiology · doi:10.1159/000551544
Ma, S., Zhang, Z., Hao, J., Li, J., Lu, B., Hao, S., Fan, Y., Yu, S., Liu, J., & Hu, H. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.07.030
Xin, D., Wadhwa, S., Zarzecka, U., Schwarz, M., Posselt, G., Weßler, S., & Uhl, A. (2026) · Proceedings - IEEE Symposium on Computer-Based Medical Systems · doi:10.1109/cbms69103.2026.00245
Ye, K., Li, H., 秦治政, Zhu, Z., Wang, R., Dou, J., Qingjia, R., Liu, X., & Wang, F. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.122505
- Authors
- Marques, M. S., Costa, A. C., Osório, H., Pinto, M. L., Relvas, S., Dinis-Ribeiro, M., Carneiro, F., Leite, M., & Figueiredo, C.
- Affiliations
- Universidade do Porto (PT)
- Hospital de São João (PT)
- i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto
- ORCID
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2021-01-01
- Volume
- 13
- Issue
- 1
- Pages
- 1-21
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- PMC
- PMC8115454
- OpenAlex
- W3160075540
- Cited by
- 23
- References
- 52
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 5
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Gut Microbes (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by)
- Funders
- European Regional Development Fund (NORTE-01-0145-FEDER-000029, PTDC/BIA-MIC/116890/2010, ROTEIRO/0028/2013 ref. LISBOA-01-0145-FEDER-022125)
- Fundação para a Ciência e a Tecnologia (SFRH/BD/21964/2005, SFRH/BPD/110065/2015, PTDC/BIA-MIC/116890/2010, SFRH/BD/95631/2013, SFRH/BD/81103/2011)
- Programa Operacional Temático Factores de Competitividade (PTDC/BIA-MIC/116890/2010)
- Topics
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- Helicobacter pylori, JAM-A, bacterial proteases, proteolytic cleavage, virulence factors, epithelial barrier integrity, cell-cell adhesion, peptic ulcer, gastric cancer
- MeSH terms
- Protein Domains, Epithelial Cells, Gastric Mucosa, Humans, Helicobacter pylori, Helicobacter Infections, Virulence Factors, Junctional Adhesion Molecule A
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
