Effects of 5,7-dihroxytryptamine administered supraspinally or spinally on the blood glucose level in D-glucose-fed and immobilization stress models
Open accessAbstract
5,7-Dihydroxytryptamine (5,7-DHT) is a neurotoxin which causes the depletion of serotonin. Moreover, the serotonergic system is the regulator of the blood glucose level. However, the role of centrally located serotonergic system in blood glucose regulation after D-glucose feed and immobilization (IMO) stress was not clearly characterized yet. Thus the present study was designed to examine the effect of 5,7-DHT administered intracerebroventricularly (i.c.v.) or intrathecally (i.t.) on the blood glucose level in D-glucose-fed and immobilization stress models. Mice were pretreated once i.c.v. or i.t. with 5,7-DHT (from 10 to 40 µg) for 3 days and D-glucose (2 g/kg) was fed orally. The blood glucose level was measured at 0, 30, 60 and 120 min after D-glucose feeding and immobilization stress initiation. We found that i.c.v. or i.t. pretreatment with 5,7-DHT attenuated the blood glucose level in both animal models. D-glucose feeding causes an increase in plasma insulin level, whereas the plasma corticosterone level was downregulated in the D-glucose-fed model. The i.c.v. or i.t. pretreatment with 5,7-DHT alone slightly increased the plasma corticosterone level. In addition, the i.c.v. or i.t. pretreatment with 5,7-DHT caused a reversal of the downregulation of plasma corticosterone level induced by D-glucose feeding, whereas immobilization stress causes an increase in plasma corticosterone and insulin levels. The i.c.v or i.t. pretreatment with 5,7-DHT attenuated the immobilization stress-induced plasma corticosterone and plasma insulin levels. Our results suggest that supraspinal and spinal depletion of serotonin appears to be responsible for the downregulation of blood glucose level in both D-glucose-fed and immobilization stress models.
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Elevated epinephrine, together with other stress hormones, induces physiological responses including increased blood sugar and liver glycogen mobilization.
“The elevated epinephrine, together with other stress hormones, induces a range of physiological responses in preparation for the fight-or-flight response, including increased blood sugar level, glycogen mobilization in the liver, etc (Buira et al., 2004; Fernandez et al., 2000; Park et al., 2016; Kang et al., 2015).”
From Intestinal microbiota modulates adrenomedullary response through Nod1 sensing in chromaffin cells (2021) · cites this paper as Park et al., 2016
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Intestinal microbiota modulates adrenomedullary response through Nod1 sensing in chromaffin cells
Xiang, C., Chen, P., Zhang, Q., Li, Y., Pan, Y., Xie, W., Sun, J., & Liu, Z. (2021) · iScience · doi:10.1016/j.isci.2021.102849 · Cited by 15 · see citing works
- Authors
- Park, S.-H., Sim, Y.-B., Kim, S.-S., Lee, J.-R., Sharma, N., & Suh, H.-W.
- Affiliations
- Hallym University (KR)
- Seoul National University (KR)
- Corresponding author
- Suh, Hong-Won
- Venue
- Animal Cells and Systems
- Publisher
- Informa UK Limited
- Published
- 2016-08-20
- Volume
- 20
- Issue
- 5
- Pages
- 289-295
- ISSN
- 1976-8354 (ISSN-L)
- 2151-2485
- OpenAlex
- W2508167328
- Cited by
- 1
- References
- 43
- Citations by year
- 2021: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Animal Cells and Systems (publishedVersion)
- Funders
- Priority Research Centers (NRF-2009-0094071, NRF-2014R1A1A1006791)
- National Research Foundation of Korea
- Ministry of Education, Science and Technology
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- 5,7-dihydroxytryptamine, serotonin depletion, serotonergic system, blood glucose regulation, restraint stress, glucose feeding, corticosterone, insulin, intracerebroventricular administration, intrathecal administration, neurotoxins
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