The DOI matches its Crossref record; 171 of the 171 references it cites were found in a registry or an index.
Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis
Open accessAbstract
The primary etiological agent for the initiation and progression of periodontal disease is the dental plaque biofilm which is an organized aggregation of microorganisms residing within a complex intercellular matrix. The non-specific plaque hypothesis was the first attempt to explain the role of the dental biofilm in the pathogenesis of periodontal diseases. However, the introduction of sophisticated diagnostic and laboratory assays has led to the realisation that the development of periodontitis requires more than a mere increase in the biomass of dental plaque. Indeed, multispecies biofilms exhibit complex interactions between the bacteria and the host. In addition, not all resident microorganisms within the biofilm are pathogenic, since beneficial bacteria exist that serve to maintain a symbiotic relationship between the plaque microbiome and the host's immune-inflammatory response, preventing the emergence of pathogenic microorganisms and the development of dysbiosis. This review aims to highlight the development and structure of the dental plaque biofilm and to explore current literature on the transition from a healthy (symbiotic) to a diseased (dysbiotic) biofilm in periodontitis and the associated immune-inflammatory responses that drive periodontal tissue destruction and form mechanistic pathways that impact other systemic non-communicable diseases.
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Citations
Cites
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Periodontitis: from microbial immune subversion to systemic inflammation
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“severe and destructive form, periodontitis [1]].”
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The Oral Microbiota: Dynamic Communities and Host Interactions
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Occlusal Caries: Biological Approach for Its Diagnosis and Management
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Treatment of stage I–III periodontitis—The EFP S3 level clinical practice guideline
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Self-citation
Cited by
Oral microbiome: a review of its impact on oral and systemic health
Rajasekaran, J. J., Krishnamurthy, H. K., Bosco, J., Jayaraman, V., Krishna, K., Wang, T., & Bei, K. (2024) · Microorganisms · doi:10.3390/microorganisms12091797 · Cited by 272
Metadata
- Authors
- Abdulkareem, A. A., Al-Taweel, F. B., Al-Sharqi, A. J. B., Gul, S. S., Sha, A., & Chapple, I. L. C.
- Venue
- Journal of Oral Microbiology
- Publisher
- Informa UK Limited
- Published
- 2023-04-02
- Volume
- 15
- Issue
- 1
- Pages
- 2197779-2197779
- ISSN
- 2000-2297 (ISSN-L)
- OpenAlex
- W4362585778
- Cited by
- 367
- References
- 171
- FWCI
- 86.02
- Type
- journal article
- Language
- en
- Open access
- gold
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- The paper
- Abdulkareem, A. A., Al-Taweel, F. B., Al-Sharqi, A. J. B., Gul, S. S., Sha, A., & Chapple, I. L. C. (2023). Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis. Journal of Oral Microbiology. https://doi.org/10.1080/20002297.2023.2197779
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
