The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Rho GTPases: Regulation and roles in cancer cell biology
Open accessAbstract
Rho GTPases are well known for their roles in regulating cell migration, and also contribute to a variety of other cellular responses. They are subdivided into 2 groups: typical and atypical. The typical Rho family members, including RhoA, Rac1 and Cdc42, cycle between an active GTP-bound and inactive GDP-bound conformation, and are regulated by GEFs, GAPs and GDIs, whereas atypical Rho family members have amino acid substitutions that alter their ability to interact with GTP/GDP and hence are regulated by different mechanisms. Both typical and atypical Rho GTPases contribute to cancer progression. In a few cancers, RhoA or Rac1 are mutated, but in most cancers expression levels and/or activity of Rho GTPases is altered. Rho GTPase signaling could therefore be therapeutically targeted in cancer treatment.
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Cites
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Self-citation
Metadata
- Authors
- Haga, R. B., & Ridley, A. J.
- Venue
- Small GTPases
- Publisher
- Informa UK Limited
- Published
- 2016-09-26
- Volume
- 7
- Issue
- 4
- Pages
- 207-221
- ISSN
- 2154-1248 (ISSN-L)
- 2154-1256
- OpenAlex
- W2520842278
- Cited by
- 559
- References
- 14
- FWCI
- 11.29
- Type
- journal article
- Language
- en
- Open access
- green
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