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Cited by 39Cellular Mechanics and InteractionsMechanisms of cancer metastasisCancer Cells and Metastasis

Actin dynamics during tumor cell dissemination

Open access
Chandrani Mondal, Julie S. Di Martino, Jose Javier Bravo‐Cordero·2021·International Review of Cell and Molecular Biology
DOI 10.1016/bs.ircmb.2020.09.004PMC PMC8246644
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Abstract

The actin cytoskeleton is a dynamic network that regulates cellular behavior from development to disease. By rearranging the actin cytoskeleton, cells are capable of migrating and invading during developmental processes; however, many of these cellular properties are hijacked by cancer cells to escape primary tumors and disseminate to distant organs in the body. In this review article, we highlight recent work describing how cancer cells regulate the actin cytoskeleton to achieve efficient invasion and metastatic colonization. We also review new imaging technologies that are capable of revealing the complex architecture and regulation of the actin cytoskeleton during motility and invasion of tumor cells.

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  • The ARP2/3 complex is a critical mediator of the entire metastatic cascade, from migration to invasion and in vivo metastatic spread.

    “The ARP2/3 complex is a critical mediator of the entire metastatic cascade; from migration to invasion and in vivo metastatic spread (Molinie & Gautreau, 2018, Mondal et al., 2021).”

    From SHARPIN S146 phosphorylation mediates ARP2/3 interaction, cancer cell invasion and metastasis (2022) · cites this paper as Mondal et al., 2021

    The Lamellipodia section (page unavailable) describes Arp2/3 activation as a mechanism that generates protrusions driving cancer-cell migration. It also discusses invasion through related actin-regulatory complexes, but does not establish that Arp2/3 itself is a critical mediator of the entire metastatic cascade or of in vivo metastatic spread. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • ARP2/3-dependent lamellipodia formation promotes cell migration and invasion.

    “ARP2/3-dependent lamellipodia formation promotes cell migration and invasion (Molinie & Gautreau, 2018, Mondal et al., 2021, Suraneni, Rubinstein et al., 2012).”

    From SHARPIN S146 phosphorylation mediates ARP2/3 interaction, cancer cell invasion and metastasis (2022) · cites this paper as Mondal et al., 2021

    The Lamellipodia section (page unavailable) says lamellipodia can drive cancer-cell migration and describes Arp2/3 activation as a mechanism of their formation. It also says lamellipodin supports lamellipodial protrusion and can promote 3D invasion, but does not specifically say that Arp2/3-dependent lamellipodia formation promotes invasion. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Mondal, C., Martino, J. S. D., & Bravo‐Cordero, J. J.
Affiliations
Tisch Cancer Institute (US)
Corresponding author
Jose Javier Bravo‐Cordero
ORCID
Venue
International Review of Cell and Molecular Biology
Publisher
Elsevier
Published
2021
Volume
360
Pages
65-98
ISSN
  • 0074-7696 (ISSN-L)
  • 1937-6448
DOI
10.1016/bs.ircmb.2020.09.004
PMC
PMC8246644
OpenAlex
W3109327701
Cited by
39
References
4
Citations by year
2026: 7 · 2025: 6 · 2024: 12 · 2023: 10 · 2022: 3 · 2021: 1
FWCI
5.81
Type
book chapter
Language
en
Open access
Licence
Locations
  • International review of cytology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Cancer Institute (CA244780, K22CA196750)
  • Adenoid Cystic Carcinoma Research Foundation
  • National Institutes of Health (T32 CA078207)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
actin cytoskeleton, tumor cell dissemination, metastasis, tumor invasion, cell motility, metastatic colonization, actin dynamics
MeSH terms
Actins, Animals, Cell Cycle, Cell Movement, Humans, Neoplasm Metastasis, Neoplasms, Epithelial-Mesenchymal Transition

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