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Association of fractures with the incidence of amyotrophic lateral sclerosis

Peters, Tracy L., Weibull, Caroline E., Fang, Fang, Sandler, Dale P., Lambert, Paul C., Ye, Weimin, Kamel, Freya·2017·Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
DOI 10.1080/21678421.2017.1300287PMC PMC5527744
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  • When assessing the time since fracture, the association was significant up to 18 years, suggesting that ALS may be impacting bone health.

    “When assessing the time since fracture, however, the association was significant up to 18 years, suggesting that ALS may be impacting bone health [70].”

    From Head Injury and Amyotrophic Lateral Sclerosis: Population-Based Study from the National ALS Registry (2025) · cites this paper as [70]

  • A prospective study investigating the association between fractures and ALS risk found a positive association between fractures and ALS risk and that osteoporotic, non-osteoporotic, traumatic, and non-traumatic were all associated with ALS risk.

    “However, a prospective study investigating the association between fractures and ALS risk found a positive association between fractures and ALS risk and that osteoporotic, non-osteoporotic, traumatic, and non-traumatic were all associated with ALS risk.”

    From Head Injury and Amyotrophic Lateral Sclerosis: Population-Based Study from the National ALS Registry (2025) · cites this paper as [70]

  • It is likely that skeletal function and health are impacted as the disease progresses, increasing the risk of fractures, and not that skull fractures increase the risk of ALS.

    “Therefore, it is likely that skeletal function and health are impacted as the disease progresses, increasing the risk of fractures, and not that skull fractures increase the risk of ALS [70,71,72,79].”

    From Head Injury and Amyotrophic Lateral Sclerosis: Population-Based Study from the National ALS Registry (2025) · cites this paper as [70]

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Authors
Peters, T. L., Weibull, C. E., Fang, F., Sandler, D. P., Lambert, P. C., Ye, W., & Kamel, F.
Affiliations
  • Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,
  • Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA, and
Venue
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Publisher
Informa UK Limited
Published
2017-03-20
Volume
18
Issue
5-6
Pages
419-425
ISSN
  • 2167-8421
  • 2167-9223
DOI
10.1080/21678421.2017.1300287
PMC
PMC5527744
Cited by
19
References
2
Language
en
Funders
  • Swedish Research Council (80748301, 2015-03170)
  • Swedish Research Council for Health (2011-0172)
  • Karolinska Institutet
  • the National Institutes of Health/Karolinska Institutet graduate partnership programme
  • Intramural Research Program of National Institutes of Health
  • National Institute of Environmental Health Sciences (Z01-ES-049005)
  • EU Joint Programme - Neurodegenerative Disease Research (JPND) project
  • the Intramural Research Program of National Institutes of Health
  • the Swedish Research Council for Health, Working life, and Welfare (2011-0172)

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