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Cited by 4Amyotrophic Lateral Sclerosis ResearchTraumatic Brain Injury ResearchSpinal Cord Injury Research

Head Injury and Amyotrophic Lateral Sclerosis: Population-Based Study from the National ALS Registry

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Raymond, Jaime, Howard, Ileana M., Berry, Jasmine, Larson, Theodore, Horton, D. Kevin, Mehta, Paul·2025·Brain Sciences
DOI 10.3390/brainsci15020143PMC PMC11852576
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Abstract

Background/Objectives: To examine if head injury (HI) is associated with age at ALS diagnosis in the United States. Methods: In this cross-sectional populationf-based analysis, we identified patients with ALS who were registered from 2015 to 2023 who completed the Registry’s head trauma survey module. The association between HI and age at ALS diagnosis was assessed using multivariate analysis. Results: Of the 3424 respondents, 56.6% had experienced a HI. The adjusted odds ratio (aOR) for an ALS diagnosis before age 60 years for patients with a HI was 1.24 (95% CI, 1.07–1.45). One or two HIs had an aOR of 1.15 (95% CI, 0.97–1.36), and five or more HIs had an aOR of 1.58 (95% CI, 1.19–2.09). HI before age 18 years yielded an aOR of 2.03 (95% CI, 1.53–2.70) as well as HI between the ages of 18 and 30 years (aOR = 1.48, 95% CI: 1.06–2.06)). When narrowing the analysis to patients with HI before age 18 compared with patients with no HI, we found an association with HI that led to an emergency department or hospital visit (aOR = 1.50 (95% CI: 1.21–1.86)). Conclusions: In this cross-sectional analysis of ALS patients, HIs occurring in childhood and early adulthood and the number of HIs increased the odds of being diagnosed before age 60 years. These results suggest that HI continues to be a risk factor for ALS and could be associated with a younger age of diagnosis.

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Cited by

Sorted by citations

Authors
Raymond, J., Howard, I. M., Berry, J., Larson, T., Horton, D. K., & Mehta, P.
Affiliations
  • Centers for Disease Control and Prevention (US)
  • University of Washington (US)
  • Agency for Toxic Substances and Disease Registry/Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Corresponding author
Raymond, Jaime
ORCID
Venue
Brain Sciences
Publisher
MDPI AG
Published
2025-01-31
Volume
15
Issue
2
Pages
143
ISSN
2076-3425 (ISSN-L)
DOI
10.3390/brainsci15020143
PMC
PMC11852576
OpenAlex
W4407040882
Cited by
4
References
10
Citations by year
2026: 4
FWCI
2.44
Type
journal article
Language
en
Open access
Licence
Locations
  • Brain Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
CDC/National ALS Registry
Topics
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
Keywords
amyotrophic lateral sclerosis, traumatic brain injury, age at diagnosis, pediatric head injury, National ALS Registry, emergency department visits

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