The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Emerging COVID-19 coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26
Open accessAbstract
The recent outbreak of pneumonia-causing COVID-19 in China is an urgent global public health issue with an increase in mortality and morbidity. Here we report our modelled homo-trimer structure of COVID-19 spike glycoprotein in both closed (ligand-free) and open (ligand-bound) conformation, which is involved in host cell adhesion. We also predict the unique N- and O-linked glycosylation sites of spike glycoprotein that distinguish it from the SARS and underlines shielding and camouflage of COVID-19 from the host the defence system. Furthermore, our study also highlights the key finding that the S1 domain of COVID-19 spike glycoprotein potentially interacts with the human CD26, a key immunoregulatory factor for hijacking and virulence. These findings accentuate the unique features of COVID-19 and assist in the development of new therapeutics.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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Ezrin Interacts with the SARS Coronavirus Spike Protein and Restrains Infection at the Entry Stage
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Cited by
The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity
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Singh, A. K., Gupta, R., Ghosh, A., & Misra, A. (2020) · Diabetes & Metabolic Syndrome: Clinical Research & Reviews · doi:10.1016/j.dsx.2020.04.004 · Cited by 893
Immune response, inflammation, and the clinical spectrum of COVID-19
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Radzikowska, U., Ding, M., Tan, G., Zhakparov, D., Peng, Y., Wawrzyniak, P., Wang, M., Li, S., Morita, H., Altunbulakli, C., et al. (2020) · Allergy · doi:10.1111/all.14429 · Cited by 543
COVID-19: Drug Targets and Potential Treatments
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Metadata
- Authors
- Vankadari, N., & Wilce, J. A.
- Venue
- Emerging Microbes & Infections
- Publisher
- Informa UK Limited
- Published
- 2020-01
- Volume
- 9
- Issue
- 1
- Pages
- 601-604
- ISSN
- 2222-1751 (ISSN-L)
- OpenAlex
- W3012088820
- Cited by
- 585
- References
- 10
- FWCI
- 16.27
- Type
- journal article
- Language
- en
- Open access
- gold
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- Vankadari, N., & Wilce, J. A. (2020). Emerging COVID-19 coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26. Emerging Microbes & Infections. https://doi.org/10.1080/22221751.2020.1739565
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