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Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension
Open accessAbstract
The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs), are associated with clinical outcomes remains unknown. COVID-19 patients with hypertension were enrolled to evaluate the effect of RAS inhibitors. We observed that patients receiving ACEI or ARB therapy had a lower rate of severe diseases and a trend toward a lower level of IL-6 in peripheral blood. In addition, ACEI or ARB therapy increased CD3 and CD8 T cell counts in peripheral blood and decreased the peak viral load compared to other antihypertensive drugs. This evidence supports the benefit of using ACEIs or ARBs to potentially contribute to the improvement of clinical outcomes of COVID-19 patients with hypertension.
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“Consistent with animal models, it was reported that AngII–AT1R axis inhibitors may be beneficial for COVID-19 patients (360–363) to decrease serum IL-6 levels (360).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [360]
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IL-6 in inflammation, autoimmunity and cancer
Hirano, T. (2021) · International Immunology · doi:10.1093/intimm/dxaa078 · Cited by 1,453
Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19
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COVID-19 and Multiorgan Response
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COVID-19 in people with diabetes: understanding the reasons for worse outcomes
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Collider bias undermines our understanding of COVID-19 disease risk and severity
Griffith, G. J., Morris, T. T., Tudball, M. J., Herbert, A., Mancano, G., Pike, L., Sharp, G. C., Sterne, J., Palmer, T. M., Davey Smith, G., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19478-2 · Cited by 826
Metadata
- Authors
- Meng, J., Xiao, G., Zhang, J., He, X., Ou, M., Bi, J., Yang, R., Di, W., Wang, Z., Li, Z., Gao, H., Liu, L., & Zhang, G.
- Affiliations
- Southern University of Science and Technology (CN)
- Shenzhen Bay Laboratory (CN)
- Corresponding author
- Gao, Hong
- Liu, Lei
- Zhang, Guoliang
- ORCID
- Venue
- Emerging Microbes & Infections
- Publisher
- Informa UK Limited
- Published
- 2020-01
- Volume
- 9
- Issue
- 1
- Pages
- 757-760
- ISSN
- 2222-1751 (ISSN-L)
- PMC
- PMC7170368
- OpenAlex
- W3013871850
- Cited by
- 619
- References
- 14
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 22 · 2023: 31 · 2022: 61 · 2021: 194 · 2020: 297
- FWCI
- 19.12
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Emerging Microbes & Infections (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
- ImmPort
- Funders
- National Natural Science Foundation of China (81873958)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- COVID-19 pandemic, hypertension, renin-angiotensin system, ACE inhibitors, angiotensin receptor blockers, SARS-CoV-2, interleukin-6, T-cell count, viral load, antihypertensive therapy
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, COVID-19 Drug Treatment, Aged, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, C-Reactive Protein, China, Female, Humans, Hypertension, Male, Middle Aged, Pneumonia, Viral, Renin-Angiotensin System, Retrospective Studies, Interleukin-6, Treatment Outcome, CD3 Complex, Coronavirus Infections, CD8-Positive T-Lymphocytes, Viral Load, Angiotensin II Type 1 Receptor Blockers, Pandemics
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