The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer
Open accessAbstract
The oncometabolite, D-2-hydroxyglutarate, accumulates in various cancers because of acquired mutations in isocitrate dehydrogenase 1 & 2. Here, we describe a new mechanism for D-2-hydroxyglutarate accumulation in breast cancer. It involves c-Myc signaling and alcohol dehydrogenase, iron-containing protein 1 (ADHFE1) and leads to metabolic reprogramming, de-differentiation, and increased mammary tumorigenesis.
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The reviewed studies suggest involvement of Myc in the production of 2-HG.
“The above studies suggest the involvement of Myc in the production of 2-HG.”
From HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells (2021) · cites this paper as [176]
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( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
Losman, J.-A., Looper, R. E., Koivunen, P., Lee, S., Schneider, R. K., McMahon, C., Cowley, G. S., Root, D. E., Ebert, B. L., & Kaelin, W. G. (2013) · Science · doi:10.1126/science.1231677 · Cited by 703
l -2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer
Shim, E.-H., Livi, C. B., Rakheja, D., Tan, J., Benson, D., Parekh, V., Kho, E.-Y., Ghosh, A. P., Kirkman, R., Velu, S., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0696 · Cited by 280
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Research works printed but not linked: 8
- 10.4161/23723556.2014.992217 · DOI
- 10.1172/JCI71180 · DOI · Paper page
- 10.1016/j.ccr.2010.01.020 · DOI · Paper page
- 10.1038/nature10860 · DOI · Paper page
- 10.1016/j.bbrc.2014.08.003 · DOI
- 10.1172/JCI93815 · DOI
- 10.1126/science.283.5402.676 · DOI
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HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells
Lee, S.-H., Golinska, M., & Griffiths, J. R. (2021) · Cells · doi:10.3390/cells10092371 · Cited by 169
2-Hydroxyglutarate in Cancer Cells
Ježek, P. (2020) · Antioxidants & Redox Signaling · doi:10.1089/ars.2019.7902 · Cited by 130
Metadata
- Authors
- Mishra, P., Tang, W., & Ambs, S.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Ambs, Stefan
- Venue
- Molecular & Cellular Oncology
- Publisher
- Informa UK Limited
- Published
- 2018-04-19
- Volume
- 5
- Issue
- 3
- Pages
- e1432260
- ISSN
- 2372-3548 (ISSN-L)
- 2372-3556
- PMC
- PMC6150044
- OpenAlex
- W2791265647
- Cited by
- 16
- References
- 2
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 3
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Molecular & Cellular Oncology (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- HHS | NIH | National Cancer Institute (ZIA BC 010887)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
- Keywords
- D-2-hydroxyglutarate, oncometabolites, isocitrate dehydrogenase, c-Myc signaling, metabolic reprogramming, breast cancer, mammary carcinogenesis, alcohol dehydrogenase
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