CoChat
Sign Up
Cited by 452Hormonal and reproductive studiesEstrogen and related hormone effectsSexual Differentiation and Disorders

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Estradiol in elderly men

Open access
Vermeulen, A., Kaufman, J. M., Goemaere, S., Van Pottelberg, I.·2002·The Aging Male
DOI 10.1080/tam.5.2.98.102
Open this paper in CoChat — free accountOpen PDF

Abstract

The role of estrogens in male physiology has become more evident, as a consequence of the discovery of human models of estrogen deficiency such as estrogen resistance or aromatase deficiency. In males, testosterone is the major source of plasma estradiol, the main biologically active estrogen, only 20% of which is secreted by the testes. Plasma estrone, 5% of which is converted to plasma estradiol, originates from tissue aromatization of, mainly adrenal, androstenedione. The plasma concentration of estradiol in males is 2-3 ng/dl and its production rate in blood is 25-40 micrograms/24 h; both of these values are significantly higher than in postmenopausal women. Plasma levels of estradiol do not necessarily reflect tissue-level activity as peripherally formed estradiol is partially metabolized in situ; thus, not all enters the general circulation, with a fraction remaining only locally active. Of the factors influencing plasma estradiol levels, plasma testosterone is a major determinant. However, the age-associated decrease in testosterone levels is scarcely reflected in plasma estradiol levels, as a result of increasing aromatase activity with age and the age-associated increase in fat mass. Free and bioavailable estradiol levels do decrease modestly with age as does the ratio of free testosterone to free estradiol, the latter testifying to the age-associated increased aromatization of testosterone. Estradiol levels are highly significantly positively related to body fat mass and more specifically to subcutaneous abdominal fat, but not to visceral (omental) fat. Indeed, aromatase activity in omental fat is only one-tenth of the activity in gluteal fat. Estrogens in males play an important role in the regulation of the gonadotropin feedback, several brain functions, bone maturation, regulation of bone resorption and in lipid metabolism. Moreover, they affect skin metabolism and are an important factor determining sex interest in man.

Overview

Integrity signals

Registry

Crossref · 10.1080/tam.5.2.98.102

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 29 references

Research works printed but not linked: 9

  1. Baird DT, 1973, J Endocrinol, 53, 286
  2. Baird DT, 1969, Rec Prog Horm Res, 25, 611
  3. Khosla S, 2001, J Clin Endocrinol Metab, 86, 3555, 10.1210/jcem.86.8.7736 · DOI · Paper page
  4. Belanger A, 1994, J Clin Endocrinol Metab, 79, 1086
  5. Madden B, 2000, J Clin Endocrinol Metab, 85, 3276
  6. Killinger DW, 1990, Ann NY Acad Sci, 5, 191
  7. Hayes FJ, 2000, J Clin Endocrinol Metab, 85, 3027
  8. Turner T, 1994, Endocr Rev, 15, 275
  9. Barrett-Connor E, 2000, J Clin Endocrinol Metab, 85, 219

Cited by

Sorted by citations

See all 452

Related

See all

Metadata

Authors
Vermeulen, A., Kaufman, J. M., Goemaere, S., & Van Pottelberg, I.
Affiliations
Ghent University Hospital (BE)
ORCID
Venue
The Aging Male
Publisher
Informa UK Limited
Published
2002-01
Volume
5
Issue
2
Pages
98-102
ISSN
  • 1368-5538 (ISSN-L)
  • 1473-0790
DOI
10.1080/tam.5.2.98.102
OpenAlex
W1999158243
Cited by
452
References
29
Citations by year
2026: 8 · 2025: 12 · 2024: 17 · 2023: 19 · 2022: 20 · 2021: 23 · 2020: 19 · 2019: 14 · 2018: 23 · 2017: 17 · 2016: 16 · 2015: 27 · 2014: 25 · 2013: 16 · 2012: 23
FWCI
9.93
Type
journal article
Language
en
Open access
Locations
  • The Aging Male (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords
estradiol, older men, male physiology, aromatase, testosterone, estrone, estrogen resistance, aromatase deficiency, fat mass, abdominal fat, gonadotropin feedback, bone metabolism, lipid metabolism, aging
MeSH terms
Adrenal Glands, Aged, Aged, 80 and over, Aging, Aromatase, Estradiol, Humans, Male, Middle Aged, Obesity, Testosterone

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Estradiol in elderly men. https://app.cochat.ai/papers/10.1080/tam.5.2.98.102
The paper
Vermeulen, A., Kaufman, J. M., Goemaere, S., & Van Pottelberg, I. (2002). Estradiol in elderly men. The Aging Male. https://doi.org/10.1080/tam.5.2.98.102