Cited by 199Hormonal and reproductive studiesMenopause: Health Impacts and TreatmentsEstrogen and related hormone effects

Endogenous Sex Hormones in Relation to Age, Sex, Lifestyle Factors, and Chronic Diseases in a General Population: The Tromsø Study

Bjørnerem, Åshild, Straume, Bjørn, Midtby, Monica, Fønnebø, Vinjar, Sundsfjord, Johan, Svartberg, Johan, Acharya, Ganesh, Øian, Pål +1 more·2004·The Journal of Clinical Endocrinology & Metabolism

Abstract

The role played by endogenous hormones in many diseases makes it important to understand factors influencing their levels. This study examined the distribution of total and free estradiol, FSH, and dehydroepiandrosterone sulfate (DHEAS) by age and sex and associations of these hormones with body mass index (BMI), lifestyle factors, and chronic diseases. Plasma samples taken from 1555 men and 1952 women 25-84 yr of age in 1994-1995 Tromsø Study were analyzed in 2001. Total estradiol increased with age among men (P < 0.001), with or without adjustment for BMI and lifestyle factors. FSH increased with age both in men (P < 0.001) as well as pre- (P < 0.001) and postmenopausal women (P = 0.01) after similar adjustment, and DHEAS decreased with age in both sexes (P < 0.001). With increasing BMI, free estradiol increased in men (P = 0.004), total and free estradiol increased in postmenopausal women (P < 0.001), and FSH decreased in men (P = 0.03) and postmenopausal women (P < 0.001). Men with chronic diseases had lower levels of DHEAS, compared with healthy men (P < 0.001). Smokers had higher DHEAS levels than nonsmokers. Further studies are needed to confirm these hormonal changes with age and disease.

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Crossref · 10.1210/jc.2004-0735

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Authors
Bjørnerem, Å., Straume, B., Midtby, M., Fønnebø, V., Sundsfjord, J., Svartberg, J., Acharya, G., Øian, P., & Berntsen, G. K. R.
Affiliations
  • UiT The Arctic University of Norway (NO)
  • University Hospital of North Norway (NO)
Corresponding author
Bjørnerem, Åshild
Venue
The Journal of Clinical Endocrinology & Metabolism
Published
2004-12
Volume
89
Issue
12
Pages
6039-6047
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
OpenAlex
W2130271063
Cited by
199
References
45
Citations by year
2026: 3 · 2025: 6 · 2024: 4 · 2023: 9 · 2022: 8 · 2021: 10 · 2020: 9 · 2019: 8 · 2018: 11 · 2017: 9 · 2016: 11 · 2015: 5 · 2014: 7 · 2013: 9 · 2012: 16
FWCI
5.29
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
endogenous sex hormones, estradiol, free estradiol, follicle-stimulating hormone, dehydroepiandrosterone sulfate, aging, sex differences, body mass index, lifestyle factors, smoking, chronic disease, menopause, Tromsø Study
MeSH terms
Adult, Aged, Aged, 80 and over, Aging, Chronic Disease, Estradiol, Female, Follicle Stimulating Hormone, Humans, Life Style, Male, Menopause, Middle Aged, Prospective Studies, Sex Characteristics, Gonadal Steroid Hormones, Smoking, Estrogen Replacement Therapy, Body Mass Index, Dehydroepiandrosterone Sulfate

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