Electrophysiological response during auditory gap detection: Biomarker for sensory and communication alterations in autism spectrum disorder?
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Sensory symptoms, including auditory processing deficits, are common in autism spectrum disorder (ASD). Processing of temporal aspects of auditory input is understudied; yet, deficits in this domain could contribute to language-related impairments. In children with ASD and well-matched controls, this study examined electrophysiological response to silent gaps in auditory stimuli. Results revealed attenuated amplitude of the P2 event-related potential (ERP) component in ASD. The P2 amplitude reduction was also associated with sensory, language, and diagnostic features. These results suggest that neural response during auditory gap detection is a promising ASD biomarker that could be useful for stratifying subgroups and evaluating treatment response.
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Compared with TD peers, ASD children with intact cognitive skills present reduced P2 amplitude in gap detection tasks.
“Regarding temporal processing with gap detection tasks, when compared with TD peers, ASD children with intact cognitive skills present reduced P2 amplitude (Foss-feig et al. 2018).”
From Autism Spectrum Disorder and auditory sensory alterations: a systematic review on the integrity of cognitive and neuronal functions related to auditory processing (2023) · cites this paper as Foss-feig et al. 2018
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Gonçalves, A. M., & Monteiro, P. (2023) · Journal of Neural Transmission · doi:10.1007/s00702-023-02595-9 · Cited by 88 · see citing works
- Authors
- Foss-Feig, J. H., Stavropoulos, K. K. M., McPartland, J. C., Wallace, M. T., Stone, W. L., & Key, A. P.
- Affiliations
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai Hospital, One Gustave Levy Place, New York, New York
- University of California, Riverside (US)
- Yale University (US)
- Vanderbilt University (US)
- University of Washington (US)
- Vanderbilt University Medical Center (US)
- ORCID
- Venue
- Developmental Neuropsychology
- Publisher
- Informa UK Limited
- Published
- 2018-02-13
- Volume
- 43
- Issue
- 2
- Pages
- 109-122
- ISSN
- 1532-6942 (ISSN-L)
- 8756-5641
- PMC
- PMC5972824
- OpenAlex
- W2789027256
- Cited by
- 16
- References
- 3
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 1 · 2023: 3 · 2021: 2 · 2020: 2 · 2019: 2
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Developmental Neuropsychology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Autism Science Foundation (Accelerator Grant (JHF))
- Autism Speaks (Dennis Weatherstone Predoctoral Fellowship (JHF))
- Brain and Behavior Research Foundation (NARSAD Young Investigator Award (JHF))
- Seaver Foundation (n/a)
- Marino Autism Research Institute (Research Award (AK))
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- autism spectrum disorder, auditory temporal processing, auditory processing deficits, sensory symptoms, language impairment, biomarkers, children
- MeSH terms
- Autism Spectrum Disorder, Adolescent, Child, Communication, Electrophysiology, Evoked Potentials, Female, Humans, Male, Biomarkers, Evoked Potentials, Auditory, Brain Stem
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