Cited by 313Fungal and yeast genetics researchAntifungal resistance and susceptibilityFungal Infections and Studies

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Fungal ß(1,3)-D-glucan synthesis

Douglas, C. M.·2001·Medical Mycology

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Abstract

The polysaccharide beta(1,3)-D-glucan is a component of the cell wall of many fungi. Synthesis of the linear polymer is catalysed by UDP-glucose beta(1,3)-D-glucan beta(3)-D-glucosyltransferase. Because this enzyme has a key role in fungal cell-wall synthesis, and because many organisms that are responsible for human mycoses, including Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans, produce walls that are rich in beta(1,3)-glucan, it has been and remains the focus of intensive study. From early characterization of the enzymatic activity in Saccharomyces cerevisiae, advances have been made in purification of the enzyme, identification of essential subunits and description of regulatory circuitry that controls expression and localization of different components of the multisubunit enzyme complex. Progress in each of these areas has been enhanced dramatically by the availability of specific inhibitors of the enzymatic reaction that produces beta(1,3)-glucan. These natural product inhibitors have utility both as tools to dissect the biology of beta(1,3)-glucan synthase and as sources for development of semisynthetic derivatives with clinical utility in treatment of human fungal disease. This review will focus on the biochemistry, genetics and regulation of the enzyme.

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Authors: Douglas, C. M.
Affiliations: Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
Corresponding author: Douglas, C. M.
Venue: Medical Mycology
Publisher: Oxford University Press (OUP)
Published: 2001-01
Volume: 39
Issue: 1
Pages: 55-66
ISSN: 0268-1218 (ISSN-L)
1369-3786
1460-2709
DOI: 10.1080/mmy.39.1.55.66
OpenAlex: W2143508569
Cited by: 312
References: 100
Citations by year: 2026: 14 · 2025: 17 · 2024: 16 · 2023: 12 · 2022: 12 · 2021: 13 · 2020: 22 · 2019: 8 · 2018: 14 · 2017: 9 · 2016: 8 · 2015: 10 · 2014: 16 · 2013: 15 · 2012: 19
FWCI: 0.54
Type: journal article
Language: en
Open access: closed
Locations: Medical Mycology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Keywords: β-1,3-glucan, fungal cell wall, enzyme regulation, enzyme subunits, enzyme inhibitors, Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans, Saccharomyces cerevisiae, human fungal diseases
MeSH terms: Fungal Proteins, Fungi, Glucans, Glucosyltransferases, Membrane Proteins, Gene Expression Regulation, Fungal, Saccharomyces cerevisiae Proteins, beta-Glucans, Echinocandins

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