The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Fungal ß(1,3)-D-glucan synthesis
Abstract
The polysaccharide beta(1,3)-D-glucan is a component of the cell wall of many fungi. Synthesis of the linear polymer is catalysed by UDP-glucose beta(1,3)-D-glucan beta(3)-D-glucosyltransferase. Because this enzyme has a key role in fungal cell-wall synthesis, and because many organisms that are responsible for human mycoses, including Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans, produce walls that are rich in beta(1,3)-glucan, it has been and remains the focus of intensive study. From early characterization of the enzymatic activity in Saccharomyces cerevisiae, advances have been made in purification of the enzyme, identification of essential subunits and description of regulatory circuitry that controls expression and localization of different components of the multisubunit enzyme complex. Progress in each of these areas has been enhanced dramatically by the availability of specific inhibitors of the enzymatic reaction that produces beta(1,3)-glucan. These natural product inhibitors have utility both as tools to dissect the biology of beta(1,3)-glucan synthase and as sources for development of semisynthetic derivatives with clinical utility in treatment of human fungal disease. This review will focus on the biochemistry, genetics and regulation of the enzyme.
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“While there is an association of FKS mutations with resistance, and biochemical data support the resistance mechanism, it has only been conclusively demonstrated that such mutations are sufficient to confer echinocandin resistance in S. cerevisiae [82], [83].”
From Global Analysis of the Evolution and Mechanism of Echinocandin Resistance in Candida glabrata (2012) · cites this paper as [82]
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Emerging Antifungal Resistance in Ocular Infections
de Oliveira, H. C., Tabuse, A. M., Höfling-Lima, A. L., & Rodrigues, A. M. (2026) · Springer eBooks · doi:10.1007/978-3-032-19923-2_3
β-Glucans from Microbial Sources: An Introduction and Overview of Their Use in the Food Industry
Razack, S. A., Ravikumar, Y., & Ray, R. C. (2026) · Springer eBooks · doi:10.1007/978-3-032-23818-4_1
Bhatia, N. M., Kumbhar, S. T., Anbhule, P. J., & Bhatia, M. S. (2026) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-026-10928-w
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Metadata
- Authors
- Douglas, C. M.
- Affiliations
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Corresponding author
- Douglas, C. M.
- Venue
- Medical Mycology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-01
- Volume
- 39
- Issue
- 1
- Pages
- 55-66
- ISSN
- 0268-1218 (ISSN-L)
- 1369-3786
- 1460-2709
- OpenAlex
- W2143508569
- Cited by
- 312
- References
- 100
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 16 · 2023: 12 · 2022: 12 · 2021: 13 · 2020: 22 · 2019: 8 · 2018: 14 · 2017: 9 · 2016: 8 · 2015: 10 · 2014: 16 · 2013: 15 · 2012: 19
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medical Mycology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Keywords
- β-1,3-glucan, fungal cell wall, enzyme regulation, enzyme subunits, enzyme inhibitors, Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans, Saccharomyces cerevisiae, human fungal diseases
- MeSH terms
- Fungal Proteins, Fungi, Glucans, Glucosyltransferases, Membrane Proteins, Gene Expression Regulation, Fungal, Saccharomyces cerevisiae Proteins, beta-Glucans, Echinocandins
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