Cited by 313Fungal and yeast genetics researchAntifungal resistance and susceptibilityFungal Infections and Studies

The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.

Fungal ß(1,3)-D-glucan synthesis

Douglas, C. M.·2001·Medical Mycology

Open this paper in CoChat — free account

Abstract

The polysaccharide beta(1,3)-D-glucan is a component of the cell wall of many fungi. Synthesis of the linear polymer is catalysed by UDP-glucose beta(1,3)-D-glucan beta(3)-D-glucosyltransferase. Because this enzyme has a key role in fungal cell-wall synthesis, and because many organisms that are responsible for human mycoses, including Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans, produce walls that are rich in beta(1,3)-glucan, it has been and remains the focus of intensive study. From early characterization of the enzymatic activity in Saccharomyces cerevisiae, advances have been made in purification of the enzyme, identification of essential subunits and description of regulatory circuitry that controls expression and localization of different components of the multisubunit enzyme complex. Progress in each of these areas has been enhanced dramatically by the availability of specific inhibitors of the enzymatic reaction that produces beta(1,3)-glucan. These natural product inhibitors have utility both as tools to dissect the biology of beta(1,3)-glucan synthase and as sources for development of semisynthetic derivatives with clinical utility in treatment of human fungal disease. This review will focus on the biochemistry, genetics and regulation of the enzyme.

Integrity signals

Registry

Crossref · 10.1080/mmy.39.1.55.66

Cites

100 of 100 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Glycosyltransferases
Paulson, J. C., & Colley, K. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84610-0 · Cited by 913
A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities
CAMPBELL, J. A., Davies, G. J., Bulone, V., & Henrissat, B. (1997) · Biochemical Journal · doi:10.1042/bj3260929u · Cited by 816
Higher plants contain homologs of the bacterial celA genes encoding the catalytic subunit of cellulose synthase.
Pear, J. R., Kawagoe, Y., Schreckengost, W. E., Delmer, D. P., & Stalker, D. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12637 · Cited by 748
Calcineurin is required for virulence of Cryptococcus neoformans
Odom, A., Muir, S., Lim, E., Toffaletti, D. L., Perfect, J., & Heitman, J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.10.2576 · Cited by 516
Identification of Yeast Rho1p GTPase as a Regulatory Subunit of 1,3-β-Glucan Synthase
Qadota, H., Python, C. P., Inoue, S., Arisawa, M., Anraku, Y., Zheng, Y., Watanabe, T., Levin, D. E., & Ohya, Y. (1996) · Science · doi:10.1126/science.272.5259.279 · Cited by 445
Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast
Stathopoulos, A. M., & Cyert, M. S. (1997) · Genes & Development · doi:10.1101/gad.11.24.3432 · Cited by 442
Multidomain architecture of beta-glycosyl transferases: implications for mechanism of action
Saxena, I. M., Brown, R. M., Fèvre, M., Geremia, R. A., & Henrissat, B. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.6.1419-1424.1995 · Cited by 440
Differential Expression and Function of Two Homologous Subunits of Yeast 1,3-β-D-Glucan Synthase
Mazur, P., Morin, N. R., Baginsky, W. F., El-Sherbeini, M., Clemas, J. A., NIELSEN, J. B. K., & Foor, F. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.10.5671 · Cited by 425
The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-beta-D-glucan synthase.
Douglas, C. M., Foor, F., Marrinan, J. A., Morin, N., Nielsen, J. B., Dahl, A. M., Mazur, P., Baginsky, W., Li, W., & el-Sherbeini, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12907 · Cited by 401
Self-citation
Structure of the Nucleotide-Diphospho-Sugar Transferase, SpsA from Bacillus subtilis, in Native and Nucleotide-Complexed Forms,
Charnock, S. J., & Davies, G. J. (1999) · Biochemistry · doi:10.1021/bi990270y · Cited by 344

Show all 100 references

Research works printed but not linked: 8

Hay GW, 1965, Methods Carbohyd Chem, 5, 251
Perez P, 1983, J Gen Microbiol, 129, 245
Hammond M, 1993, Cutaneous Antifungal Agents. New York: Marcel Dekker, 395
Schmatz DM, 1991, J Protozool, 38, 151S
Fromtling RA, 1999, Drug News Perspect, 12, 557
Mouyna I, 2000, Biochem J, 347, 741, 10.1042/0264-6021:3470741 · DOI
Kurtz MB, 1995, Yeast, 11, S561
Dixon CK, 1995, Yeast, 11, S538

Sorted by citations

The Fungal Cell Wall: Structure, Biosynthesis, and Function
Gow, N. A. R., Latge, J.-P., & Munro, C. A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0035-2016 · Cited by 1,423
The structure and synthesis of the fungal cell wall
Bowman, S. M., & Free, S. J. (2006) · BioEssays · doi:10.1002/bies.20441 · Cited by 1,320
Antifungal agents: mechanisms of action
Odds, F. C., Brown, A. J. P., & Gow, N. A. R. (2003) · Trends in Microbiology · doi:10.1016/s0966-842x(03)00117-3 · Cited by 1,202
Echinocandin antifungal drugs
Denning, D. W. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14472-8 · Cited by 1,131
Pneumocystis Pneumonia
Thomas, C. F., & LIMPER, A. H. (2004) · New England Journal of Medicine · doi:10.1056/nejmra032588 · Cited by 1,052
The cell wall: a carbohydrate armour for the fungal cell
Latgé, J. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05872.x · Cited by 987
Regulation of Cell Wall Biogenesis in Saccharomyces cerevisiae : The Cell Wall Integrity Signaling Pathway
Levin, D. E. (2011) · Genetics · doi:10.1534/genetics.111.128264 · Cited by 827
Increasing Echinocandin Resistance in Candida glabrata: Clinical Failure Correlates With Presence of FKS Mutations and Elevated Minimum Inhibitory Concentrations
Alexander, B. D., Johnson, M. D., Pfeiffer, C. D., Jiménez-Ortigosa, C., Catania, J., Booker, R., Castanheira, M., Messer, S. A., Perlin, D. S., & Pfaller, M. A. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit136 · Cited by 778
Genome sequence of the model medicinal mushroom Ganoderma lucidum
Chen, S., Xu, J., Liu, C., Zhu, Y., Nelson, D. R., Zhou, S., Li, C., Wang, L., Guo, X., Sun, Y., et al. (2012) · Nature Communications · doi:10.1038/ncomms1923 · Cited by 583
Resistance to echinocandin-class antifungal drugs.
Perlin, D. S. (2007) · Drug Resistance Updates · doi:10.1016/j.drup.2007.04.002 · Cited by 512
Candidiasis and Mechanisms of Antifungal Resistance
Bhattacharya, S., Sae-Tia, S., & Fries, B. C. (2020) · Antibiotics · doi:10.3390/antibiotics9060312 · Cited by 474
Dectin-2 Is a Pattern Recognition Receptor for Fungi That Couples with the Fc Receptor γ Chain to Induce Innate Immune Responses
Sato, K., Yang, X.-L., Yudate, T., Chung, J., Wu, J., Luby‐Phelps, K., Kimberly, R. P., Underhill, D. M., Cruz, P. D., & Ariizumi, K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606542200 · Cited by 470
Stimulation of Chitin Synthesis Rescues Candida albicans from Echinocandins
Walker, L. A., Munro, C. A., de Bruijn, I., Lenardon, M. D., McKinnon, A., & Gow, N. A. R. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000040 · Cited by 445
Specific Substitutions in the Echinocandin Target Fks1p Account for Reduced Susceptibility of Rare Laboratory and Clinical Candida sp. Isolates
Park, S., Kelly, R., Kahn, J. N., Robles, J., Hsu, M.-J., Register, E., Li, W., Vyas, V., Fan, H., Abruzzo, G., et al. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.8.3264-3273.2005 · Cited by 434
Self-citation
What makes Aspergillus fumigatus a successful pathogen? Genes and molecules involved in invasive aspergillosis
Abad, A., Fernandez-Molina, J. V., Bikandi, J., Ramirez‐Garcia, A., Margareto, J., Sendino, J., Hernando, F. L., Pontón, J., Garaizar, J., & Rementerı́a, A. (2010) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2010.10.003 · Cited by 409
β-glucan: Crucial component of the fungal cell wall and elusive MAMP in plants
Fesel, P., & Zuccaro, A. (2015) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2015.12.004 · Cited by 346
Clinical breakpoints for the echinocandins and Candida revisited: Integration of molecular, clinical, and microbiological data to arrive at species-specific interpretive criteria
Pfaller, M. A., Diekema, D. J., Andes, D. R., Arendrup, M. C., Brown, S. D., Lockhart, S. R., Motyl, M. R., & Perlin, D. S. (2011) · Drug Resistance Updates · doi:10.1016/j.drup.2011.01.004 · Cited by 340
Effect of Candida glabrata FKS1 and FKS2 Mutations on Echinocandin Sensitivity and Kinetics of 1,3-β- d -Glucan Synthase: Implication for the Existing Susceptibility Breakpoint
Garcia-Effron, G., Lee, S., Park, S., Cleary, J. D., & Perlin, D. S. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00443-09 · Cited by 323
Cell wall glucans of fungi. A review
Ruíz-Herrera, J., & Ortiz‐Castellanos, L. (2019) · The Cell Surface · doi:10.1016/j.tcsw.2019.100022 · Cited by 308
Caspofungin
Saravolatz, L. D., Deresinski, S. C., & Stevens, D. A. (2003) · Clinical Infectious Diseases · doi:10.1086/375080 · Cited by 295
A Candida Biofilm-Induced Pathway for Matrix Glucan Delivery: Implications for Drug Resistance
Taff, H. T., Nett, J. E., Zarnowski, R., Ross, K. M., Sanchez, H., Cain, M. T., Hamaker, J., Mitchell, A. P., & Andes, D. R. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002848 · Cited by 291
Current insights into the biology and pathogenesis of Pneumocystis pneumonia
Thomas, C. F., & LIMPER, A. H. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1621 · Cited by 271
Current Perspectives on Echinocandin Class Drugs
Perlin, D. S. (2011) · Future Microbiology · doi:10.2217/fmb.11.19 · Cited by 274
Correlating Echinocandin MIC and Kinetic Inhibition of fks1 Mutant Glucan Synthases for Candida albicans : Implications for Interpretive Breakpoints
Garcia-Effron, G., Park, S., & Perlin, D. S. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01162-08 · Cited by 256
Strategy to combat biofilms: a focus on biofilm dispersal enzymes
Wang, S., Zhao, Y., Breslawec, A. P., Liang, T., Deng, Z., Kuperman, L. L., & Yu, Q. (2023) · npj Biofilms and Microbiomes · doi:10.1038/s41522-023-00427-y · Cited by 265
Genes y moléculas implicados en la virulencia de Aspergillus fumigatus
Rementerı́a, A., López-Molina, N., Ludwig, A., Vivanco, A. B., Bikandi, J., Pontón, J., & Garaizar, J. (2005) · Revista Iberoamericana de Micología · doi:10.1016/s1130-1406(05)70001-2 · Cited by 237
Antimicrobial Peptides: a New Frontier in Antifungal Therapy
Cesare, G. B. D., Cristy, S. A., Garsin, D. A., & Lorenz, M. C. (2020) · mBio · doi:10.1128/mbio.02123-20 · Cited by 248
ZnO nanoparticles (ZnO-NPs) and their antifungal activity against coffee fungus Erythricium salmonicolor
Arciniegas-Grijalba, P. A., Patiño-Portela, M. C., Mosquera-Sánchez, L. P., Guerrero-Vargas, J. A., & Páez, J. E. R. (2017) · Applied Nanoscience · doi:10.1007/s13204-017-0561-3 · Cited by 230
Elevated Chitin Content Reduces the Susceptibility of Candida Species to Caspofungin
Walker, L. A., Gow, N. A. R., & Munro, C. A. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01486-12 · Cited by 214
Caspofungin Inhibits Rhizopus oryzae 1,3-β- d -Glucan Synthase, Lowers Burden in Brain Measured by Quantitative PCR, and Improves Survival at a Low but Not a High Dose during Murine Disseminated Zygomycosis
Ibrahim, A. S., Bowman, J. C., Avanesian, V., Brown, K., Spellberg, B. J., Edwards, J. E., & Douglas, C. M. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.2.721-727.2005 · Cited by 208
Self-citation
Global Analysis of the Evolution and Mechanism of Echinocandin Resistance in Candida glabrata
Singh-Babak, S. D., Babak, T., Diezmann, S., Hill, J. A., Xie, J. L., Chen, Y.-L., Poutanen, S. M., Rennie, R. P., Heitman, J., & Cowen, L. E. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002718 · Cited by 205
Mechanisms of Antifungal Properties of Metal Nanoparticles
Slavin, Y. N., & Bach, H. (2022) · Nanomaterials · doi:10.3390/nano12244470 · Cited by 222
Beta-glucans as immunostimulant in vertebrates and invertebrates
Soltanian, S., Stuyven, E., Cox, E., Sorgeloos, P., & Bossier, P. (2009) · Critical Reviews in Microbiology · doi:10.1080/10408410902753746 · Cited by 202
The Interaction Between Insoluble and Soluble Fiber
Mudgil, D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805130-6.00003-3 · Cited by 211
Candida albicans and Candida glabrata Clinical Isolates Exhibiting Reduced Echinocandin Susceptibility
Katiyar, S. K., Pfaller, M. A., & Edlind, T. D. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00349-06 · Cited by 189
Callose homeostasis at plasmodesmata: molecular regulators and developmental relevance
Storme, N. D., & Geelen, D. (2014) · Frontiers in Plant Science · doi:10.3389/fpls.2014.00138 · Cited by 179
The Potential of Antimicrobial Peptides as Biocides
Laverty, G., Gorman, S. P., & Gilmore, B. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12106566 · Cited by 171
Antifungal drug resistance of oral fungi
Niimi, M., Firth, N. A., & Cannon, R. D. (2010) · Odontology · doi:10.1007/s10266-009-0118-3 · Cited by 170
An Anti-β-Glucan Monoclonal Antibody Inhibits Growth and Capsule Formation of Cryptococcus neoformans In Vitro and Exerts Therapeutic, Anticryptococcal Activity In Vivo
Rachini, A., Pietrella, D., Lupo, P., Torosantucci, A., Chiani, P., Bromuro, C., Proietti, C., Bistoni, F., Cassone, A., & Vecchiarelli, A. (2007) · Infection and Immunity · doi:10.1128/iai.00278-07 · Cited by 165
Innate immune recognition of microbial cell wall components and microbial strategies to evade such recognitions
Vijayrajratnam, S., Nisha, N., Biswas, L., Kumar, V. A., & Biswas, R. (2013) · Microbiological Research · doi:10.1016/j.micres.2013.02.005 · Cited by 162
Stable isotope informed genome-resolved metagenomics reveals that Saccharibacteria utilize microbially-processed plant-derived carbon
Starr, E. P., Shi, S.-J., Blazewicz, S., Probst, A., Herman, D., Firestone, M., & Banfield, J. (2017) · Microbiome · doi:10.1186/s40168-018-0499-z · Cited by 136
Fks1 and Fks2 Are Functionally Redundant but Differentially Regulated in Candida glabrata: Implications for Echinocandin Resistance
Katiyar, S. K., Alastruey-Izquierdo, A., Healey, K. R., Johnson, M. E., Perlin, D. S., & Edlind, T. D. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00813-12 · Cited by 148
Cell wall integrity is dependent on the PKC1 signal transduction pathway in Cryptococcus neoformans
Gerik, K. J., Donlin, M. J., Soto, C. E., Banks, A. M., Banks, I. R., Maligie, M. A., Selitrennikoff, C. P., & Lodge, J. K. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04843.x · Cited by 146
Caspofungin: the first in a new class of antifungal agents
Kartsonis, N. A., NIELSEN, J. B. K., & Douglas, C. M. (2003) · Drug Resistance Updates · doi:10.1016/s1368-7646(03)00064-5 · Cited by 146
Self-citation
The echinocandin antifungals: an overview of the pharmacology, spectrum and clinical efficacy
Wiederhold, N. P., & Lewis, R. E. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.8.1313 · Cited by 144
New triazoles and echinocandins: mode of action, in vitro activity and mechanisms of resistance
Fera, M. T., Camera, E. L., & Sarro, A. D. (2009) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.09.67 · Cited by 136
(1,3)- -D-Glucan as a Prognostic Marker of Treatment Response in Invasive Candidiasis
Jaijakul, S., Vázquez, J. A., Swanson, R. N., & Ostrosky-Zeichner, L. L. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis456 · Cited by 137
Rezafungin—Mechanisms of Action, Susceptibility and Resistance: Similarities and Differences with the Other Echinocandins
García‐Effrón, G. (2020) · Journal of Fungi · doi:10.3390/jof6040262 · Cited by 135
Yapsins Are a Family of Aspartyl Proteases Required for Cell Wall Integrity in Saccharomyces cerevisiae
Krysan, D. J., Ting, E. L., Abeijón, C., Kroos, L., & Fuller, R. S. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.8.1364-1374.2005 · Cited by 129
Ibrexafungerp: A First-in-Class Oral Triterpenoid Glucan Synthase Inhibitor
Jallow, S., & Govender, N. P. (2021) · Journal of Fungi · doi:10.3390/jof7030163 · Cited by 129
Cell wall structure and biogenesis in Aspergillus species
Yoshimi, A., Miyazawa, K., & Abe, K. (2016) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2016.1177446 · Cited by 126
The Echinocandins: Comparison of Their Pharmacokinetics, Pharmacodynamics and Clinical Applications
Wagner, C. C., Graninger, W., Presterl, E., & Joukhadar, C. (2006) · Pharmacology · doi:10.1159/000096348 · Cited by 123
Genomic Approach to Identification of Mutations Affecting Caspofungin Susceptibility in Saccharomyces cerevisiae
Markovich, S., Yekutiel, A., Shalit, I., Shadkchan, Y., & Osherov, N. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.10.3871-3876.2004 · Cited by 122
The Mushroom Glucans: Molecules of High Biological and Medicinal Importance
Vetter, J. (2023) · Foods · doi:10.3390/foods12051009 · Cited by 122
An α‐(1,4)‐amylase is essential for α‐(1,3)‐glucan production and virulence in Histoplasma capsulatum
Marion, C. L., Rappleye, C. A., Engle, J. T., & Goldman, W. E. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05436.x · Cited by 120
Occidiofungin, a Unique Antifungal Glycopeptide Produced by a Strain of Burkholderia contaminans
Lu, S., Novák, J., Austin, F. W., Gu, G., Ellis, D., Kirk, M., Wilson-Stanford, S., Tonelli, M., & Smith, L. (2009) · Biochemistry · doi:10.1021/bi900814c · Cited by 118
The immunology of parasite infections in immunocompromised hosts
Evering, T. H., & Weiss, L. M. (2006) · Parasite Immunology · doi:10.1111/j.1365-3024.2006.00886.x · Cited by 118
Polysaccharides: Sources, Characteristics, Properties, and Their Application in Biodegradable Films
Díaz‐Montes, E. (2022) · Polysaccharides · doi:10.3390/polysaccharides3030029 · Cited by 117
Characterization ofAspergillus fumigatusmutants with reduced susceptibility to caspofungin
Gardiner, R. E., Souteropoulos, P., Park, S., & Perlin, D. S. (2005) · Medical Mycology · doi:10.1080/13693780400029023 · Cited by 110
Cell wall-associated enzymes in fungi
Rast, D. M., Baumgartner, D., Mayer, C., & Hollenstein, G. O. (2003) · Phytochemistry · doi:10.1016/s0031-9422(03)00350-9 · Cited by 110
Analysis of the phylogenetic relationships and evolution of the cell walls from yeasts and fungi
Ruíz-Herrera, J., & Ortiz‐Castellanos, L. (2009) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2009.00589.x · Cited by 108
Recent Approaches to Antifungal Therapy for Invasive Mycoses
Mathew, B. P., & Nath, M. (2009) · ChemMedChem · doi:10.1002/cmdc.200800353 · Cited by 105
Review on Current Status of Echinocandins Use
Mroczyńska, M., & Brillowska‐Dąbrowska, A. (2020) · Antibiotics · doi:10.3390/antibiotics9050227 · Cited by 113
A spergillus fumigatus devoid of cell wall β‐1,3‐glucan is viable, massively sheds galactomannan and is killed by septum formation inhibitors
Dichtl, K., Samantaray, S., Aimanianda, V., Zhu, Z., Prévost, M., Latgé, J., Ebel, F., & Wagener, J. (2014) · Molecular Microbiology · doi:10.1111/mmi.12877 · Cited by 102
Natural products targeting the synthesis of β(1,3)-D-glucan and chitin of the fungal cell wall. Existing drugs and recent findings
Curto, M.-Á., Butassi, E., Ribas, J. C., Svetaz, L. A., & Cortés, J. C. G. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153556 · Cited by 96
Changes in Cell Wall Synthesis and Ultrastructure during Paradoxical Growth Effect of Caspofungin on Four Different Candida Species
Bizerra, F. C., Melo, A. S. D. A., Katchburian, E., Freymüller, E. H., Straus, A. H., Takahashi, H. K., & Colombo, A. L. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00633-10 · Cited by 91
New Fks Hot Spot for Acquired Echinocandin Resistance in Saccharomyces cerevisiae and Its Contribution to Intrinsic Resistance of Scedosporium Species
Johnson, M. E., Katiyar, S. K., & Edlind, T. D. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01811-10 · Cited by 91
Chitin and Glucan, the Yin and Yang of the Fungal Cell Wall, Implications for Antifungal Drug Discovery and Therapy
Munro, C. A. (2013) · Advances in applied microbiology · doi:10.1016/b978-0-12-407678-5.00004-0 · Cited by 92
The Fungal Cell Wall: Structure, Biosynthesis, and Function
Gow, N. A. R., Latgé, J., & Munro, C. A. (2017) · ASM Press eBooks · doi:10.1128/9781555819583.ch12 · Cited by 92
Differential activity of the oral glucan synthase inhibitor SCY-078 against wild-type and echinocandin-resistant strains of Candida species
Pfaller, M. A., Messer, S. A., Rhomberg, P. R., Borroto-Esoda, K., & Castanheira, M. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00161-17 · Cited by 84
β-(1→3),(1→6)-Glucans: medicinal activities, characterization, biosynthesis and new horizons
Dalonso, N., Goldman, G. H., & Gern, R. M. M. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6849-x · Cited by 82
CRS–MIS in Candida glabrata: sphingolipids modulate echinocandin–Fks interaction
Healey, K. R., Katiyar, S. K., Raj, S., & Edlind, T. D. (2012) · Molecular Microbiology · doi:10.1111/j.1365-2958.2012.08194.x · Cited by 79
Discovery of a Novel Class of Orally Active Antifungal β-1,3- d -Glucan Synthase Inhibitors
Walker, S. S., Xu, Y., Triantafyllou, I., Waldman, M. F., Mendrick, C., Brown, N., Mann, P., Chau, A., Patel, R., Bauman, N., et al. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00432-11 · Cited by 75
Novel antifungal agents: a patent review (2011 – present)
Castelli, M. V., Butassi, E., Monteiro, M. C., Svetaz, L. A., Vicente, F., & Zacchino, S. A. (2014) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2014.876993 · Cited by 76
Topological and Mutational Analysis of Saccharomyces cerevisiae Fks1
Johnson, M. E., & Edlind, T. D. (2012) · Eukaryotic Cell · doi:10.1128/ec.00082-12 · Cited by 70
Yeast adaptive response to acetic acid stress involves structural alterations and increased stiffness of the cell wall
Ribeiro, R. A., Vitorino, M. V., Godinho, C. P., Bourbon-Melo, N., Robalo, T. T., Fernandes, F., Rodrigues, M. S., & Sá‐Correia, I. (2021) · Scientific Reports · doi:10.1038/s41598-021-92069-3 · Cited by 70
FsFKS1, the 1,3-β-Glucan Synthase from the Caspofungin-Resistant FungusFusarium solani
Ha, Y., Covert, S. F., & Momany, M. (2006) · Eukaryotic Cell · doi:10.1128/ec.00030-06 · Cited by 70
Bgs3p, a Putative 1,3-β-Glucan Synthase Subunit, Is Required for Cell Wall Assembly in Schizosaccharomyces pombe
Martín, V., García, B., Carnero, E., Durán, Á., & Sánchez, Y. (2003) · Eukaryotic Cell · doi:10.1128/ec.2.1.159-169.2003 · Cited by 70
Transcriptome and Proteome Exploration to Provide a Resource for the Study of Agrocybe aegerita
Wang, M., Gu, B., Huang, J. S., Jiang, S., Chen, Y., Yin, Y., Pan, Y., Yu, G., Li, Y., Wong, B. H. C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056686 · Cited by 69
Peptide antibiotics: An alternative and effective antimicrobial strategy to circumvent fungal infections
Ajesh, K., & Sreejith, K. (2009) · Peptides · doi:10.1016/j.peptides.2009.01.026 · Cited by 70
Novel strategies to fightCandidaspecies infection
Rodrigues, M. E., Silva, S. M., Azeredo, J., & Henriques, M. (2014) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2014.974500 · Cited by 69
Role for Fks1 in the Intrinsic Echinocandin Resistance of Fusarium solani as Evidenced by Hybrid Expression in Saccharomyces cerevisiae
Katiyar, S. K., & Edlind, T. D. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00020-09 · Cited by 69
Pathobiology ofPneumocystispneumonia: life cycle, cell wall and cell signal transduction
Skalski, J. H., Kottom, T. J., & LIMPER, A. H. (2015) · FEMS Yeast Research · doi:10.1093/femsyr/fov046 · Cited by 66
A complex game of hide and seek: the search for new antifungals
Ngo, H., Garneau‐Tsodikova, S., & Green, K. D. (2016) · MedChemComm · doi:10.1039/c6md00222f · Cited by 66
In search of the holy grail of antifungal therapy.
Chapman, S. W., Sullivan, D. C., & Cleary, J. D. (2008) · PubMed Central · Cited by 64
Biosynthesis of the Fungal Cell Wall Polysaccharide Galactomannan Requires Intraluminal GDP-mannose
Engel, J., Schmalhorst, P. S., & Routier, F. H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.398321 · Cited by 63
The Yin and Yang of Current Antifungal Therapeutic Strategies: How Can We Harness Our Natural Defenses?
Mambro, T. D., Guerriero, I., Aurisicchio, L., Magnani, M., & Marra, E. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00080 · Cited by 64
Current and Promising Antivirals Against Chikungunya Virus
Hucke, F. I. L., & Bugert, J. J. (2020) · Frontiers in Public Health · doi:10.3389/fpubh.2020.618624 · Cited by 64
Caspofungin: Pharmacodynamics, pharmacokinetics, clinical uses and treatment outcomes
Song, J., & Stevens, D. A. (2015) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2015.1068271 · Cited by 62
Pathogenesis and Antifungal Drug Resistance of the Human Fungal Pathogen Candida glabrata
Tscherner, M., Schwarzmüller, T., & Kuchler, K. (2011) · Pharmaceuticals · doi:10.3390/ph4010169 · Cited by 60
Glycosyltransferases and their products: cryptococcal variations on fungal themes
Klutts, J. S., Yoneda, A., Reilly, M. C., Bose, I., & Doering, T. L. (2006) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2006.00054.x · Cited by 59
The antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase
Siala, W., Kucharíková, S., Braem, A., Vleugels, J., Tulkens, P. M., Mingeot‐Leclercq, M., Dijck, P. V., & Françoise Van Bambeke, A. (2016) · Nature Communications · doi:10.1038/ncomms13286 · Cited by 62
Invasive Fungal Infections in Patients with Hematological Malignancies: Emergence of Resistant Pathogens and New Antifungal Therapies
Gamaletsou, M. N., Walsh, T. J., & Sipsas, N. V. (2018) · Turkish Journal of Hematology · doi:10.4274/tjh.2018.0007 · Cited by 59
Surfactant Protein D Increases Phagocytosis of HypocapsularCryptococcus neoformansby Murine Macrophages and Enhances Fungal Survival
Geunes-Boyer, S., Oliver, T. N., Janbon, G., Lodge, J. K., Heitman, J., Perfect, J. R., & Wright, J. R. (2009) · Infection and Immunity · doi:10.1128/iai.00088-09 · Cited by 56
Wound Care in the Neonatal Intensive Care Unit
Fox, M. D. (2011) · Neonatal Network The Journal of Neonatal Nursing · doi:10.1891/0730-0832.30.5.291 · Cited by 53
Yeast species-specific, differential inhibition of β-1,3-glucan synthesis by poacic acid and caspofungin
Lee, K. K., Kubo, K., Abdelaziz, J. A., Cunningham, I., Dantas, A. D. S., Chen, X., Okada, H., Ohya, Y., & Gow, N. A. R. (2018) · The Cell Surface · doi:10.1016/j.tcsw.2018.09.001 · Cited by 52
Extracellular polysaccharides produced by Ganoderma formosanum stimulate macrophage activation via multiple pattern-recognition receptors
Wang, C.-L., Lu, C.-Y., Pi, C.-C., Zhuang, Y., Chu, C., Liu, W.-H., & Chen, C. (2012) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-12-119 · Cited by 52
Modification of the cell wall structure of Saccharomyces cerevisiae strains during cultivation on waste potato juice water and glycerol towards biosynthesis of functional polysaccharides
Bzducha‐Wróbel, A., Błażejak, S., Kieliszek, M., Pobiega, K., Falana, K., & Janowicz, M. (2018) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2018.06.305 · Cited by 50
Micafungin is a novel anti-viral agent of chikungunya virus through multiple mechanisms
Ho, Y., Liu, F., Yeh, C., Yang, C. M., Lin, C.-C., Lin, T., Hsieh, P., Hu, M., Gong, Z., & Lu, J. (2018) · Antiviral Research · doi:10.1016/j.antiviral.2018.10.005 · Cited by 49
The Genome of the Medicinal Macrofungus Sanghuang Provides Insights Into the Synthesis of Diverse Secondary Metabolites
Shao, Y., Guo, H., Zhang, J., Liu, H., Wang, K., Zuo, S., Xu, P., Xia, Z., Zhou, Q., Zhang, H., et al. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.03035 · Cited by 50

Authors: Douglas, C. M.
Affiliations: Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
Corresponding author: Douglas, C. M.
Venue: Medical Mycology
Publisher: Oxford University Press (OUP)
Published: 2001-01
Volume: 39
Issue: 1
Pages: 55-66
ISSN: 0268-1218 (ISSN-L)
1369-3786
1460-2709
DOI: 10.1080/mmy.39.1.55.66
OpenAlex: W2143508569
Cited by: 312
References: 100
Citations by year: 2026: 14 · 2025: 17 · 2024: 16 · 2023: 12 · 2022: 12 · 2021: 13 · 2020: 22 · 2019: 8 · 2018: 14 · 2017: 9 · 2016: 8 · 2015: 10 · 2014: 16 · 2013: 15 · 2012: 19
FWCI: 0.54
Type: journal article
Language: en
Open access: closed
Locations: Medical Mycology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Keywords: β-1,3-glucan, fungal cell wall, enzyme regulation, enzyme subunits, enzyme inhibitors, Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans, Saccharomyces cerevisiae, human fungal diseases
MeSH terms: Fungal Proteins, Fungi, Glucans, Glucosyltransferases, Membrane Proteins, Gene Expression Regulation, Fungal, Saccharomyces cerevisiae Proteins, beta-Glucans, Echinocandins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Fungal ß(1,3)-D-glucan synthesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks