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Cited by 173Sexual function and dysfunction studiesHormonal and reproductive studiesUrological Disorders and Treatments

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Oral testosterone undecanoate reverses erectile dysfunction associated with diabetes mellitus in patients failing on sildenafil citrate therapy alone

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Kalinchenko, S. Y., Kozlov, G. I., Gontcharov, N. P., Katsiya, G. V.·2003·The Aging Male
DOI 10.1080/tam.6.2.94.99
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Abstract

AIMS: To evaluate the cause of failure of sildenafil citrate (Viagra) to restore erections in patients with organic erectile dysfunction (ED) associated with type II diabetes mellitus (DM) and receiving oral antidiabetic drugs. METHODS: Diabetic ED patients (n = 120), aged 43-74 years, failing to respond at least three times to 100 mg Viagra were evaluated. After at least 2 weeks' treatment with oral testosterone undecanoate (Andriol), 100 mg Viagra was used before coitus. ED was assessed with the International Index of Erectile Function (IIEF). Serum total testosterone, prolactin, thyroid stimulating hormone, lipid profile and prostate-specific antigen (PSA) were determined by standard methods and prostate volume by digital rectal examination. Age-matched diabetic ED patients (n = 100) served as controls for baseline values. RESULTS: Viagra non-responders had, at baseline, significantly lower testosterone and more depressed libido than controls. Andriol restored testosterone to normal levels and increased libido. In 84/120 (70%) Viagra non-responders, combined therapy with Andriol induced satisfactory erections, a significant increase in IIEF scale (question (Q) 3 from 2.0 +/- 0.2 to 3.7 +/- 0.3, Q4 from 1.9 +/- 0.1 to 3.4 +/- 0.2, Q12 from 1.0 +/- 0.1 to 4.2 +/- 0.4) and increased sexual contacts from 0.5 to 3-4 per month. No adverse events were noted, and PSA levels remained below 4 ng/ml. CONCLUSION: Decreased testosterone levels in patients with ED and type II DM receiving oral antidiabetic against may be responsible for failure to respond to sildenafil citrate therapy. Combination with oral testosterone undecanoate restores sexual function in these patients.

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Research works printed but not linked: 8

  1. Vinic A, 1998, Diabetes Rev, 1, 16
  2. Gomula A., 2001, Androl Genital Surg, 4, 34
  3. Katzenstein L., 2001, Med Inform Press, 28
  4. Guay AT, 1995, J Clin Endocrinol Metab, 80, 3546
  5. Sufi SB, WHO Matched Reagent Programme Method Manual
  6. Goncharov NP, Asian J Androl
  7. Goncharov NP, 2001, Probl Endocrinol, 47, 23
  8. Sadovsky R, 2002, Clin Pract, 55, 115

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Metadata

Authors
Kalinchenko, S. Y., Kozlov, G. I., Gontcharov, N. P., & Katsiya, G. V.
Affiliations
Endocrinology Research Center (RU)
Venue
The Aging Male
Publisher
Informa UK Limited
Published
2003-01
Volume
6
Issue
2
Pages
94-99
ISSN
  • 1368-5538 (ISSN-L)
  • 1473-0790
DOI
10.1080/tam.6.2.94.99
OpenAlex
W2032560652
Cited by
173
References
13
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 6 · 2017: 2 · 2016: 5 · 2015: 6 · 2014: 4 · 2013: 14 · 2012: 11
FWCI
9.23
Type
journal article
Language
en
Open access
Locations
  • The Aging Male (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Urology › Urological Disorders and Treatments
Keywords
erectile dysfunction, type 2 diabetes, testosterone undecanoate, sildenafil citrate, combination therapy, androgen deficiency, sexual desire, sexual function, oral antidiabetic drugs, International Index of Erectile Function
MeSH terms
Sildenafil Citrate, Aged, Diabetes Mellitus, Type 2, Humans, Erectile Dysfunction, Male, Middle Aged, Piperazines, Purines, Sulfones, Testosterone, Vasodilator Agents, Case-Control Studies, Treatment Failure, Testosterone Congeners

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