The DOI matches its Crossref record.
Thymoquinone Is a Potent Superoxide Anion Scavenger
Abstract
The antioxidant and pro-oxidant effects of thymoquinone (TQ), a natural main constituent of the volatile oil of Nigella saliva seeds, and a synthetic structurally-related tert-butylhydroquinone (TBHQ), were examined in vitro. Both TQ and TBHQ efficiently inhibited iron-dependent microsomal lipid peroxidation in a concentration-dependent manner with median inhibitory concentration (IC50) values of 16.8 and 14.9 microM, respectively. TBHQ was stronger than TQ as a scavenger of 2,2'-diphenyl-p-picrylhydrazyl radical (DPPH) (IC50 = 5 microM, 200 times more active than TQ) and as a scavenger of hydroxyl radical (OH*) with an IC50 of 4.6 microM (approximately 10 times more active than TQ). TQ was more active than TBHQ as a superoxide anion scavenger with IC50 of 3.35 microM compared to 18.1 microM for TBHQ. Only TBHQ significantly promoted DNA damage in the bleomycin-Fe(III) system. The results suggest that both TQ and TBHQ have strong antioxidant potentials through scavenging ability of different free radicals. Moreover, the data indicate that TQ is acting mainly as a potent superoxide anion scavenger.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Immunomodulatory and therapeutic properties of the Nigella sativa L. seed
Salem, M. L. (2005) · International Immunopharmacology · doi:10.1016/j.intimp.2005.06.008 · Cited by 853
Phytochemistry, pharmacology, and therapeutic uses of black seed ( Nigella sativa )
Kooti, W., Hasanzadeh-Noohi, Z., Sharafi-Ahvazi, N., Asadi-Samani, M., & Ashtary-Larky, D. (2016) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(16)30088-7 · Cited by 308
Thymoquinone and diallyl sulfide protect against fipronil-induced oxidative injury in rats
Abdel-Daim, M. M., Shaheen, H. M., Abushouk, A. I., Toraih, E. A., Fawzy, M. S., Alansari, W. S., Aleya, L., & Bungau, S. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-2386-3 · Cited by 65
Metadata
- Authors
- Badary, O. A., Taha, R. A., Gamal El-Din, A. M., & Abdel-Wahab, M. H.
- Venue
- Drug and Chemical Toxicology
- Publisher
- Informa UK Limited
- Published
- 2003-01
- Volume
- 26
- Issue
- 2
- Pages
- 87-98
- ISSN
- 0148-0545 (ISSN-L)
- 1525-6014
- OpenAlex
- W2120005420
- Cited by
- 447
- References
- 0
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Thymoquinone Is a Potent Superoxide Anion Scavenger. https://app.cochat.ai/papers/10.1081/dct-120020404
- The paper
- Badary, O. A., Taha, R. A., Gamal El-Din, A. M., & Abdel-Wahab, M. H. (2003). Thymoquinone Is a Potent Superoxide Anion Scavenger. Drug and Chemical Toxicology. https://doi.org/10.1081/dct-120020404
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
