Evaluation of rapidly disintegrating tablets prepared by a direct compression method
Abstract
To make rapidly disintegrating tablets with sufficient mechanical integrity as well as a pleasant taste, microcrystalline cellulose (MCC), Tablettose (TT), and crosslinked sodium carboxymethyl cellulose (Ac-di-sol) or erythritol (ET) were formulated. Tablets were made by a direct compression method (I). Tablet properties such as porosity, tensile strength, and disintegration time were determined. The tensile strength and disintegration time were selected as response variables, tablet porosity and parameters representing the characteristics of formulation were selected as controlling factors, and their relation was determined by the polynomial regression method. Response surface plots and contour plots of tablet tensile strength and disintegration time were also constructed. The optimum combination of tablet porosity and formulation was obtained by superimposing the contour diagrams of tablet tensile strength and disintegration time. Rapidly disintegrating tablets with durable structure and desirable taste could be prepared within the obtained optimum region.
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Porosity is a dependable and essential quality attribute for tablets, and it governs the mass transport processes behind disintegration and dissolution.
“Tablet porosity is a reliable and fundamental critical quality attribute which controls key mass transport mechanisms that govern disintegration and dissolution behaviour.”
From A Fast and Non-destructive Terahertz Dissolution Assay for Immediate Release Tablets (2021) · cites this paper as [26]
At very high porosity levels, certain disintegrants do not always follow the expected faster disintegration or dissolution behavior.
“However, this is not always the case for certain types of disintegrants at very high tablet porosity levels (e.g., for rapidly disintegrating or dissolving tablets).”
From A Fast and Non-destructive Terahertz Dissolution Assay for Immediate Release Tablets (2021) · cites this paper as [26]
Swelling of disintegrants such as CCS has been reported to involve gel formation that can substantially lengthen disintegration time.
“The swelling of disintegrant like CCS has been reported to be accompanied by gel formation that can significantly prolong the disintegration time 26 .”
From A Fast and Non-destructive Terahertz Dissolution Assay for Immediate Release Tablets (2021) · cites this paper as [26]
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Fast Dissolving Tablet: As A Potential Drug Delivery System
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- Authors
- Bi, Y. X., Sunada, H., Yonezawa, Y., & Danjo, K.
- Affiliations
- Meijo University (JP)
- ORCID
- Bi, Y. X.
- Venue
- Drug Development and Industrial Pharmacy
- Publisher
- Informa UK Limited
- Published
- 1999-01
- Volume
- 25
- Issue
- 5
- Pages
- 571-581
- ISSN
- 0363-9045 (ISSN-L)
- 1520-5762
- OpenAlex
- W2159269801
- Cited by
- 269
- References
- 8
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 8 · 2023: 11 · 2022: 8 · 2021: 8 · 2020: 6 · 2019: 8 · 2018: 7 · 2017: 16 · 2016: 14 · 2015: 14 · 2014: 18 · 2013: 23 · 2012: 19
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug Development and Industrial Pharmacy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Physical Sciences › Engineering › Computational Mechanics › Granular flow and fluidized beds
- Physical Sciences › Materials Science › Materials Chemistry › Crystallization and Solubility Studies
- Keywords
- fast disintegrating tablets, direct compression, tablet porosity, tablet tensile strength, disintegration time, microcrystalline cellulose, erythritol, sweeteners, formulation optimization, response surface methodology
- MeSH terms
- Cellulose, Chemistry, Pharmaceutical, Tablets, Technology, Pharmaceutical, Tensile Strength
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