The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.
IMPACT OF CELLULAR METABOLISM ON THE BIOLOGICAL EFFECTS OF BENZO[A]PYRENE AND RELATED HYDROCARBONS†
Abstract
Polycyclic aromatic hydrocarbons are ubiquitous contaminants in the environment. Benzo[a]pyrene (BaP), a prototypical member of this class of chemicals, has been extensively studied for its toxic effects in laboratory animals and human populations. BaP toxicity is often mediated by oxidative metabolism to reactive intermediates that interact with macromolecules leading to alterations in target cell structure and function. More recent evidence suggests that disruption of cellular signaling pathways involved in the regulation of growth and differentiation contribute significantly to the toxicity of BaP and its metabolites. This review summarizes recent advances in our understanding of biological mechanisms of BaP toxicity at the molecular level, and the role of metabolic intermediates in carcinogenesis, atherogenesis, and teratogenesis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,630
Rushmore, T. H., Morton, M. R., & Pickett, C. B. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99004-6 · Cited by 1,464
Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.
MILLER, J. A. (1970) · PubMed · Cited by 1,450
Gelboin, H. V. (1980) · Physiological Reviews · doi:10.1152/physrev.1980.60.4.1107 · Cited by 1,280
Boyle, W. J., Smeal, T., Defize, L. H. K., Angel, P., Woodgett, J. R., Karin, M., & Hunter, T. (1991) · Cell · doi:10.1016/0092-8674(91)90241-p · Cited by 1,055
Casarett and Doull's toxicology: The basic science of poisons
Pickrell, J. A. (1996) · Toxicology Letters · doi:10.1016/s0378-4274(96)90054-5 · Cited by 1,051
Venugopal, R., & Jaiswal, A. K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14960 · Cited by 1,040
Evidence for a Monoclonal Origin of Human Atherosclerotic Plaques
Benditt, E. P., & Benditt, J. M. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.6.1753 · Cited by 910
AH RECEPTOR SIGNALING PATHWAYS
Schmidt, J. V., & Bradfield, C. A. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.55 · Cited by 899
Polycyclic Hydrocarbons and Cancer
(1981) · Elsevier eBooks · doi:10.1016/b978-0-12-279203-8.x5001-0 · Cited by 747
Cited by
Polycyclic Aromatic Hydrocarbons: From Metabolism to Lung Cancer
Moorthy, B., Chu, C., & Carlin, D. J. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv040 · Cited by 801
Bioavailability and Risk Assessment of Orally Ingested Polycyclic Aromatic Hydrocarbons
Ramesh, A., Walker, S. A., Hood, D. B., Guillén, M. D., Schneider, K., & Weyand, E. H. (2004) · International Journal of Toxicology · doi:10.1080/10915810490517063 · Cited by 498
Metadata
- Authors
- Miller, K. P., & Ramos, K. S.
- Venue
- Drug Metabolism Reviews
- Publisher
- Informa UK Limited
- Published
- 2001-01
- Volume
- 33
- Issue
- 1
- Pages
- 1-35
- ISSN
- 0360-2532 (ISSN-L)
- 1097-9883
- OpenAlex
- W2036415863
- Cited by
- 332
- References
- 94
- FWCI
- 5.75
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: IMPACT OF CELLULAR METABOLISM ON THE BIOLOGICAL EFFECTS OF BENZO[A]PYRENE AND RELATED HYDROCARBONS†. https://app.cochat.ai/papers/10.1081/dmr-100000138
- The paper
- Miller, K. P., & Ramos, K. S. (2001). IMPACT OF CELLULAR METABOLISM ON THE BIOLOGICAL EFFECTS OF BENZO[A]PYRENE AND RELATED HYDROCARBONS†. Drug Metabolism Reviews. https://doi.org/10.1081/dmr-100000138
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
