Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes.
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AHR-mediated induction of detoxification enzymes such as Cyp1a1 and Cyp1b1 metabolizes ligands like BaP into toxic diol epoxide intermediates.
“The adaptive and toxic pathways often overlap, as AHR-mediated induction of detoxification enzymes like Cyp1a1 and Cyp1b1 metabolize ligands such as BaP to yield toxic diol epoxide intermediates (Gelboin, 1980).”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Gelboin, 1980
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Rodent Genetic Models of Ah Receptor Signaling
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“The adaptive and toxic pathways often overlap, as AHR-mediated induction of detoxification enzymes like Cyp1a1 and Cyp1b1 metabolize ligands such as BaP to yield toxic diol epoxide intermediates (Gelboin 1980).”
Background
- Authors
- Gelboin, H. V.
- Corresponding author
- Gelboin, H V
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 1980-10
- Volume
- 60
- Issue
- 4
- Pages
- 1107-1166
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W1881840670
- Cited by
- 1,280
- References
- 0
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 19 · 2023: 14 · 2022: 18 · 2021: 22 · 2020: 20 · 2019: 13 · 2018: 27 · 2017: 22 · 2016: 21 · 2015: 25 · 2014: 32 · 2013: 24 · 2012: 29
- FWCI
- 29.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Keywords
- benzo[a]pyrene, mixed function oxidase, cytochrome P450, enzyme regulation, carcinogenesis, enzyme activation, benzo[a]pyrene metabolism, polycyclic aromatic hydrocarbons
- MeSH terms
- Animals, Aryl Hydrocarbon Hydroxylases, Benzopyrenes, Biotransformation, Enzymes, Gene Expression Regulation, Humans, Mixed Function Oxygenases, Inactivation, Metabolic, Microsomes, Mutation, Neoplasms, Oxidoreductases, Protein Binding
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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