CoChat
Sign Up
Cited by 22Thyroid Disorders and TreatmentsBone health and osteoporosis researchThyroid and Parathyroid Surgery

Relationships Existing Between the Serum Cytokine Levels and Bone Mineral Density in Women in the Premenopausal Period Affected by Graves' Disease with Subclinical Hyperthyroidism

Ugur‐Altun, Betül, Altun, Armagan, Arikan, Ender, Guldiken, Sibel, Tugrul, Armagan·2003·Endocrine Research
DOI 10.1081/erc-120026945
Open this paper in CoChat — free account

Abstract

We examined the relationships existing between serum cytokine levels and bone mineral density (BMD) in women of premenopausal age affected by Graves' disease with subclinical hyperthyroidism. The study population consisted of 21 women with untreated hyperthyroid Graves' disease (group H) (age, 36 +/- 2 years), eight women with untreated subclinical hyperthyroid status (group SH) (age, 33 +/- 5 years) and 10 healthy women (group N) (age, 35 +/- 3 years). The following measurements were made in all patients: free T4 (fT4), free T3 (fT3), thyroid stimulating hormone (TSH), TSH receptor antibody (TRab), anti-thyroid peroxidase antibody (anti-TPO), anti-thyroglobulin antibody (anti-Tg), interleukin-2 receptor (IL-2r), interleukin-4 (IL-4), interleukin-8 (IL-8) and interleukin-13 (IL-13). IL-2r and IL-8 levels significantly increased in group H compared with group SH (p < 0.01 and p = 0.05, respectively) and group N (p < 0.001 and p = 0.02, respectively). IL-4 and IL-13 levels tended to be lower in groups H and SH compared with group N, although this difference did not reach statistical significance. Bone mineral density was significantly reduced in only two areas of the femur in group H compared with group N. There was no difference in BMD between groups SH and N. There was no correlation between thyroid hormones, serum cytokine levels and BMD in either group. In conclusion, these results suggest that there were no relationships existing between the serum level of these cytokines and BMD in women of premenopausal age affected by Graves' disease with subclinical hyperthyroidism.

Integrity signals

Registry

Crossref · 10.1081/erc-120026945

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Ugur‐Altun, B., Altun, A., Arikan, E., Guldiken, S., & Tugrul, A.
Affiliations
Trakya University (TR)
Venue
Endocrine Research
Publisher
Informa UK Limited
Published
2003-01
Volume
29
Issue
4
Pages
389-398
ISSN
  • 0743-5800 (ISSN-L)
  • 1532-4206
DOI
10.1081/erc-120026945
OpenAlex
W2138301366
Cited by
22
References
34
Citations by year
2026: 1 · 2025: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 4
FWCI
0.41
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrine Research (publishedVersion)
  • PubMed (publishedVersion)
  • Trakya University's Institutional Open Access System (Trakya University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Keywords
Graves' disease, subclinical hyperthyroidism, bone mineral density, serum cytokines, interleukin-2 receptor, interleukin-8, IL-4, IL-13, premenopausal women, thyroid autoantibodies, femoral bone density
MeSH terms
Adult, Female, Femur, Graves Disease, Humans, Hyperthyroidism, Bone Density, Cytokines, Premenopause

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review