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Translation of mRNA injected into Xenopus oocytes is specifically inhibited by antisense RNA.
Open accessAbstract
The bacteriophage SP6 promoter and RNA polymerase were used to synthesize sense and antisense RNAs coding for the enzymes thymidine kinase (TK) and chloramphenicol acetyl transferase (CAT). Injection of antisense CAT RNA into frog oocytes inhibited expression of sense CAT mRNA. Similarly, antisense TK RNA inhibited expression of sense TK mRNA. Antisense RNAs were stable in oocytes and had no detectable effect on either the expression of endogenous proteins or on the expression of nonhomologous RNA transcripts. CAT activity expressed from a plasmid transcribed in the oocyte nucleus was also inhibited by antisense RNA injected into the oocyte cytoplasm. The data suggest that antisense RNA will be useful in identifying the function of specific mRNA sequences during early development of the frog.
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Citations
Cited by
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Davis, R. L., Weintraub, H., & Lassar, A. B. (1987) · Cell · doi:10.1016/0092-8674(87)90585-x · Cited by 3,385
Self-citationConversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein
Lee, J. E., Hollenberg, S. M., Snider, L., Turner, D. L., Lipnick, N., & Weintraub, H. (1995) · Science · doi:10.1126/science.7754368 · Cited by 1,023
Self-citationExpression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.
Turner, D. L., & Weintraub, H. (1994) · Genes & Development · doi:10.1101/gad.8.12.1434 · Cited by 1,019
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BASS, B. (1987) · Cell · doi:10.1016/0092-8674(87)90239-x · Cited by 441
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Metadata
- Authors
- Harland, R., & Weintraub, H.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1985-09-01
- Volume
- 101
- Issue
- 3
- Pages
- 1094-1099
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2134721282
- Cited by
- 198
- References
- 0
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Harland, R., & Weintraub, H. (1985). Translation of mRNA injected into Xenopus oocytes is specifically inhibited by antisense RNA. The Journal of cell biology. https://doi.org/10.1083/jcb.101.3.1094
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