The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.
Open accessAbstract
In Drosophila, the proneural genes of the achaete-scute complex encode transcriptional activators that can commit cells to a neural fate. We have isolated cDNAs for two Xenopus achaete-scute homologs, ASH3a and ASH3b, which are expressed in a subset of central nervous system (CNS) neuroblasts during early neurogenesis. After expressing either ASH3 protein in developing Xenopus embryos, we find enlargement of the CNS at the expense of adjacent non-neural ectoderm. Analysis of molecular markers for neural, epidermal, and neural crest cells indicates that CNS expansion occurs as early as neural plate formation. ASH3-dependent CNS enlargement appears to require neural induction, as it does not occur in animal cap explants. Inhibition of DNA synthesis shows that additional CNS tissue does not depend on cell division--rather it reflects conversion of prospective neural crest and epidermal cells to a neural fate. The differentiation of the early forming primary neurons also seems to be prevented by ASH3 expression. This may be secondary to the observed activation of Xotch transcription by ASH3.
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Cites
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Self-citationHistone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression
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Metadata
- Authors
- Turner, D. L., & Weintraub, H.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1994-06-15
- Volume
- 8
- Issue
- 12
- Pages
- 1434-1447
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2005462392
- Cited by
- 1,019
- References
- 70
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Turner, D. L., & Weintraub, H. (1994). Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. Genes & Development. https://doi.org/10.1101/gad.8.12.1434
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