FGF/FGFR signaling in health and disease

The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function

Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481 · see citing works

Origin and physiological roles of inflammation

Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618 · see citing works

Fibroblast growth factor signalling: from development to cancer

Turner, N., & Grose, R. (2010) · Nature Reviews. Cancer · doi:10.1038/nrc2780 · Cited by 2,689 · see citing works

Role of platelet-derived growth factors in physiology and medicinePreprint

Andræ, J., Gallini, R., & Betsholtz, C. (2008) · Genes & Development · doi:10.1101/gad.1653708 · Cited by 2,444 · see citing works

What we talk about when we talk about fat

Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373 · see citing works

Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

Zeisberg, E. M., Tarnavski, O., Zeisberg, M., Dorfman, A. L., McMullen, J. R., Gustafsson, E., Chandraker, A. K., Yuan, X., Pu, W. T., Roberts, A. B., et al. (2007) · Nature Medicine · doi:10.1038/nm1613 · Cited by 2,224 · see citing works

FGF-21 as a novel metabolic regulator

Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125 · see citing works

The Fibroblast Growth Factor signaling pathway

Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050 · see citing works

FGF-23 Is a Potent Regulator of Vitamin D Metabolism and Phosphate Homeostasis

Shimada, T., Hasegawa, H., Yamazaki, Y., Muto, T., Hino, R., Takeuchi, Y., Fujita, T., Nakahara, K., Fukumoto, S., & Yamashita, T. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.0301264 · Cited by 1,883 · see citing works

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865 · see citing works

Klotho converts canonical FGF receptor into a specific receptor for FGF23

Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S., & Yamashita, T. (2006) · Nature · doi:10.1038/nature05315 · Cited by 1,846 · see citing works

Cholangiocarcinoma — evolving concepts and therapeutic strategies

Ilyas, S. I., Khan, S. A., Hallemeier, C. L., Kelley, R. K., & Gores, G. J. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.157 · Cited by 1,626 · see citing works

Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504 · see citing works

Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495 · see citing works

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., et al. (2012) · Genes & Development · doi:10.1101/gad.177857.111 · Cited by 1,478 · see citing works

Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23

White, K., Evans, W. E., O'Riordan, J., Speer, M., Econs, M., Lorenz-Depiereux, B., Grabowski, M., Meitinger, T., & Strom, T. (2000) · Nature Genetics · doi:10.1038/81664 · Cited by 1,467 · see citing works

A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

Hunter, D. J., Kraft, P., Jacobs, K. B., Cox, D. G., Yeager, M., Hankinson, S. E., Wacholder, S., Wang, Z., Welch, R. A., Hutchinson, A. A., et al. (2007) · Nature Genetics · doi:10.1038/ng2075 · Cited by 1,463 · see citing works

Evidence That Human Cardiac Myocytes Divide after Myocardial Infarction

Beltrami, A. P., Urbanek, K., Kajstura, J., Yan, S., Finato, N., Bussani, R., Nadal‐Ginard, B., Silvestri, F., Leri, A., Beltrami, C. A., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200106073442303 · Cited by 1,426 · see citing works

Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia

Shimada, T., Mizutani, S., Muto, T., Yoneya, T., Hino, R., Takeda, S., Takeuchi, Y., Fujita, T., Fukumoto, S., & Yamashita, T. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.101545198 · Cited by 1,391 · see citing works

Fgf10 is essential for limb and lung formation

Sekine, K., Ohuchi, H., Fujiwara, M., Yamasaki, M., Yoshizawa, T., Sato, T., Yagishita, N., Matsui, D., Koga, Y., Itoh, N., et al. (1999) · Nature Genetics · doi:10.1038/5096 · Cited by 1,283 · see citing works

Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease

Isakova, T., on behalf of the Chronic Renal Insufficiency Cohort (CRIC) Study Group, WAHL, P. W., Vargas, G. S., Gutiérrez, O. M., Scialla, J. J., Xie, H., Appleby, D. H., Nessel, L. C., Bellovich, K. A., et al. (2011) · Kidney International · doi:10.1038/ki.2011.47 · Cited by 1,271 · see citing works

Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis

Presta, M., Dell’Era, P., Mitola, S. M. F., Moroni, E., Ronca, R., & Rusnati, M. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.01.004 · Cited by 1,257 · see citing works

The Molecular Basis of G Protein–Coupled Receptor Activation

Weis, W. I., & Kobilka, B. K. (2018) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-033910 · Cited by 1,227 · see citing works

Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism

Feng, J. Q., Ward, L. M., Liu, S., Lu, Y., Xie, Y., Yuan, B., Yu, X., Rauch, F., Davis, S. I., Zhang, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1905 · Cited by 1,199 · cited 2× · see citing works

Crystal Structure of a Ternary FGF-FGFR-Heparin Complex Reveals a Dual Role for Heparin in FGFR Binding and Dimerization

Schlessinger, J., Plotnikov, A. N., Ibrahimi, O. A., Eliseenkova, A. V., Yeh, B. K., Yayon, A., Linhardt, R. J., & Mohammadi, M. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00073-3 · Cited by 1,199 · see citing works

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.-S., Lindberg, R. A., et al. (2009) · Diabetes · doi:10.2337/db08-0392 · Cited by 1,151 · see citing works

In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy

Nelson, C. E., Hakim, C. H., Ousterout, D. G., Thakore, P. I., Moreb, E. A., Rivera, R. M. C., Madhavan, S., Pan, X., Ran, F. A., Yan, W. X., et al. (2016) · Science · doi:10.1126/science.aad5143 · Cited by 1,144 · see citing works

A gene (PEX) with homologies to endopeptidases is mutated in patients with X–linked hypophosphatemic rickets

Francis, F., Hennig, S., Korn, B., Reinhardt, R., de Jong, P., Poustka, A. J., Lehrach, H. R., Rowe, P. S., Goulding, J. N., Summerfield, T. C., et al. (1995) · Nature Genetics · doi:10.1038/ng1095-130 · Cited by 1,095 · see citing works

Fibroblast growth factor receptor 3 is a negative regulator of bone growth.

Deng, C.-X., Wynshaw-Boris, A., Zhou, F., Kuo, A., & Leder, P. (1996) · Cell · doi:10.1016/s0092-8674(00)81069-7 · Cited by 1,095 · see citing works

Transcriptional control of the inflammatory response

Medzhitov, R., & Horng, T. (2009) · Nature Reviews Immunology · doi:10.1038/nri2634 · Cited by 1,035 · see citing works

Fibroblast Growth Factor 21 Corrects Obesity in Mice

Coskun, T., Bina, H. A., Schneider, M. A., Dunbar, J. D., Hu, C. C., Chen, Y., Moller, D. E., & Kharitonenkov, A. (2008) · Endocrinology · doi:10.1210/en.2008-0816 · Cited by 1,031 · see citing works

FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition

Cross, M. J., & Claesson‐Welsh, L. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01676-x · Cited by 1,008 · see citing works

The parathyroid is a target organ for FGF23 in rats

Ben‐Dov, I. Z., Galitzer, H., Lavi-Moshayoff, V., Goetz, R. M., Kuro‐o, M., Mohammadi, M., Sirkis, R., Naveh‐Many, T., & Silver, J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32409 · Cited by 951 · see citing works

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype

Yin, H., Xue, W., Chen, S., Bogorad, R. L., Benedetti, E., Grompe, M., Koteliansky, V., Sharp, P. A., Jacks, T., & Anderson, D. G. (2014) · Nature Biotechnology · doi:10.1038/nbt.2884 · Cited by 951 · see citing works

Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy.

Rando, T. A., & Blau, H. M. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.125.6.1275 · Cited by 944 · see citing works

Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

Zhang, X., Yeung, D. C. Y., Karpisek, M., Stejskal, D., Zhou, Z.-G., Liu, F., Wong, R. L. C., Chow, W.-S., Tso, A. W. K., Lam, K. S. L., et al. (2008) · Diabetes · doi:10.2337/db07-1476 · Cited by 908 · see citing works

The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes

Gaich, G., Chien, J. Y., Fu, H., Glass, L. C., Deeg, M. A., Holland, W. L., Kharitonenkov, A., Bumol, T., Schilske, H. K., & Moller, D. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.005 · Cited by 885 · see citing works

Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3

Colvin, J. S., Bohne, B. A., Harding, G. W., McEwen, D. G., & Ornitz, D. M. (1996) · Nature Genetics · doi:10.1038/ng0496-390 · Cited by 868 · see citing works

An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis

Moerlooze, L. D., Spencer‐Dene, B., Revest, J., Hajihosseini, M. K., Rosewell, I. R., & Dickson, C. (2000) · Development · doi:10.1242/dev.127.3.483 · Cited by 863 · see citing works

The Arterial Pole of the Mouse Heart Forms from Fgf10-Expressing Cells in Pharyngeal Mesoderm

Kelly, R. G., Brown, N. A., & BUCKINGHAM, M. E. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00040-5 · Cited by 854 · see citing works

The aged niche disrupts muscle stem cell quiescence

Chakkalakal, J. V., Jones, K. M., Basson, M. A., & Brack, A. S. (2012) · Nature · doi:10.1038/nature11438 · Cited by 851 · see citing works

Therapeutic antibodies for autoimmunity and inflammation

Chan, A. C., & Carter, P. J. (2010) · Nature reviews. Immunology · doi:10.1038/nri2761 · Cited by 840 · see citing works

c-kit+ cells minimally contribute cardiomyocytes to the heart

van Berlo, J. H., Kanisicak, O., Maillet, M., Vagnozzi, R. J., Karch, J. M., Lin, S. J., Middleton, R., Marbán, E., & Molkentin, J. D. (2014) · Nature · doi:10.1038/nature13309 · Cited by 794 · see citing works

fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.Preprint

Yamaguchi, T. P., Harpal, K., Henkemeyer, M. J., & Rossant, J. (1994) · Genes & Development · doi:10.1101/gad.8.24.3032 · Cited by 776 · see citing works

Murine FGFR-1 is required for early postimplantation growth and axial organization.Preprint

Deng, C.-X., Wynshaw-Boris, A., Shen, M. M., Daugherty, C., Ornitz, D., & Leder, P. (1994) · Genes & Development · doi:10.1101/gad.8.24.3045 · Cited by 775 · see citing works

Engineering adeno-associated viruses for clinical gene therapy

Kotterman, M. A., & Schaffer, D. V. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3742 · Cited by 761 · see citing works

Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas

Cappellen, D., de Oliveira, C. C. B., Ricol, D., de Medina, S. D., Bourdin, J., Sastre-Garau, X., Chopin, D., Thiery, J., & Radvanyi, F. (1999) · Nature Genetics · doi:10.1038/12615 · Cited by 743 · see citing works

The Klotho proteins in health and disease

Kuro-o, M. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0078-3 · Cited by 707 · see citing works

FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

Potthoff, M. J., Inagaki, T., Satapati, S., Ding, X., He, T., Goetz, R., Mohammadi, M., Finck, B. N., Mangelsdorf, D. J., Kliewer, S. A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904187106 · Cited by 704 · see citing works

Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

Fon Tacer, K., Bookout, A. L., Ding, X., Kurosu, H., John, G. B., Wang, L., Goetz, R., Mohammadi, M., Kuro-o, M., Mangelsdorf, D. J., et al. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0142 · Cited by 700 · see citing works

Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice

Lin, Z., Tian, H., Lam, K. S. L., Lin, S., Hoo, R. C. L., Konishi, M., Itoh, N., Wang, Y., Bornstein, S. R., Xu, A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.005 · Cited by 691 · see citing works

Functions of heparan sulfate proteoglycans in cell signaling during development

Lin, X. (2004) · Development · doi:10.1242/dev.01522 · Cited by 678 · see citing works

Conversion of vascular endothelial cells into multipotent stem-like cells

Medici, D., Shore, E. M., Lounev, V. Y., Kaplan, F. S., Kalluri, R., & Olsen, B. R. (2010) · Nature Medicine · doi:10.1038/nm.2252 · Cited by 678 · see citing works

Endothelial to Mesenchymal Transition: Role in Physiology and in the Pathogenesis of Human Diseases

Piera-Velázquez, S., & Jiménez, S. A. (2019) · Physiological Reviews · doi:10.1152/physrev.00021.2018 · Cited by 669 · see citing works

FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development.

Ohuchi, H., Hori, Y., Yamasaki, M., Harada, H., Sekine, K., Kato, S., & Itoh, N. (2000) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1006/bbrc.2000.3721 · Cited by 663 · see citing works

Cause of Death in Patients with Reduced Kidney Function

Thompson, S., James, M. T., Wiebe, N., Hemmelgarn, B. R., Manns, B., Klarenbach, S. W., & Tonelli, M. A. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014070714 · Cited by 662 · see citing works

Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth

Yu, K., Xu, J.-S., Liu, Z.-H., Šošić, D., Shao, J.-S., Olson, E., Towler, D., & Ornitz, D. (2003) · Development · doi:10.1242/dev.00491 · Cited by 654 · see citing works

Pharmacological Treatment of Coronary Artery Disease With Recombinant Fibroblast Growth Factor-2

Simons, M., Annex, B. H., Laham, R. J., Kleiman, N. S., Henry, T. D., Dauerman, H. L., Udelson, J. E., Gervino, E. V., Pike, M. C., Whitehouse, M. J., et al. (2002) · Circulation · doi:10.1161/hc0802.104407 · Cited by 646 · see citing works

Regulation of Fracture Repair by Growth Factors

Bolander, M. E. (1992) · Experimental Biology and Medicine · doi:10.3181/00379727-200-43410a · Cited by 637 · see citing works

FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

Kir, S., Beddow, S. A., Samuel, V. T., Miller, P., Previs, S. F., Suino-Powell, K., Xu, H. E., Shulman, G. I., Kliewer, S. A., & Mangelsdorf, D. J. (2011) · Science · doi:10.1126/science.1198363 · Cited by 637 · see citing works

Cellular and molecular mechanisms in kidney fibrosis

Duffield, J. S. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72267 · Cited by 631 · see citing works

Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue

Hondares, E., Iglesias, R., Giralt, A., Gonzalez, F. J., Giralt, M., Mampel, T., & Villarroya, F. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.215889 · Cited by 623 · see citing works

Correction of a genetic disease in mouse via use of CRISPR-Cas9

Wu, Y., Liang, D., Wang, Y., Bai, M., Tang, W., Bao, S., Yan, Z., Li, D., & Li, J. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.10.016 · Cited by 614 · see citing works

A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome

Muenke, M., Schell, U., Hehr, A., Robin, N. H., Losken, H. W., Schinzel, A., Pulleyn, L. J., Rutland, P., Reardon, W., Malcolm, S., et al. (1994) · Nature Genetics · doi:10.1038/ng1194-269 · Cited by 614 · see citing works

Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities

Beck, L., Karaplis, A. C., Amizuka, N., Hewson, A. S., Ozawa, H., & Tenenhouse, H. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5372 · Cited by 607 · see citing works

p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytesPreprint

Engel, F. B., Schebesta, M., Duong, M. T., Lü, G., Ren, S. V., Madwed, J. B., Jiang, H., Wang, Y., & Keating, M. T. (2005) · Genes & Development · doi:10.1101/gad.1306705 · Cited by 595 · see citing works

Bone Marrow Neovascularization, Plasma Cell Angiogenic Potential, and Matrix Metalloproteinase-2 Secretion Parallel Progression of Human Multiple Myeloma

Vacca, A., Ribatti, D., Presta, M., Minischetti, M., Iurlaro, M., Ria, R., Albini, A., Bussolino, F., & Dammacco, F. (1999) · Blood · doi:10.1182/blood.v93.9.3064 · Cited by 593 · see citing works

Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3

Tavormina, P. L., Shiang, R., Thompson, L., Zhu, Y.-Z., Wilkin, D. J., Lachman, R., Wilcox, W., Rimoin, D., Cohn, D., & Wasmuth, J. (1995) · Nature Genetics · doi:10.1038/ng0395-321 · Cited by 591 · see citing works

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

Markan, K. R., Naber, M. C., Ameka, M. K., Anderegg, M. D., Mangelsdorf, D. J., Kliewer, S. A., Mohammadi, M., & Potthoff, M. J. (2014) · Diabetes · doi:10.2337/db14-0595 · Cited by 590 · see citing works

Shedding of the Matrix Metalloproteinases MMP-2, MMP-9, and MT1-MMP as Membrane Vesicle-Associated Components by Endothelial Cells

Taraboletti, G., D’Ascenzo, S., Borsotti, P., Giavazzi, R., Pavan, A., & Dolo, V. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64887-0 · Cited by 588 · see citing works

Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin

Williams, E. J., Furness, J., Walsh, F. S., & Doherty, P. (1994) · Neuron · doi:10.1016/0896-6273(94)90027-2 · Cited by 585 · see citing works

Fibroblast Growth Factor 19 Increases Metabolic Rate and Reverses Dietary and Leptin-Deficient Diabetes

Fu, L., John, L. M., Adams, S. H., Yu, X. X., Tomlinson, E., Renz, M. E., Williams, P. M., Soriano, R. H., Corpuz, R. T., Moffat, B., et al. (2004) · Endocrinology · doi:10.1210/en.2003-1671 · Cited by 580 · see citing works

Transgenic Mice Expressing Human Fibroblast Growth Factor-19 Display Increased Metabolic Rate and Decreased Adiposity

Tomlinson, E., Fu, L., John, L., Hultgren, B., Huang, X., Renz, M., Stephan, J. P., Tsai, S. P., Powell-Braxton, L., French, D., et al. (2002) · Endocrinology · doi:10.1210/endo.143.5.8850 · Cited by 576 · see citing works

p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice

Bernet, J. D., Doles, J. D., Hall, J. K., Kelly Tanaka, K., Carter, T. A., & Olwin, B. B. (2014) · Nature Medicine · doi:10.1038/nm.3465 · Cited by 573 · see citing works

Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion–Positive Cholangiocarcinoma

Goyal, L., Saha, S. K., Liu, L. Y., Siravegna, G., Leshchiner, I., Ahronian, L. G., Lennerz, J. K., Vu, P., Deshpande, V., Kambadakone, A. R., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-1000 · Cited by 562 · see citing works

A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice

Yang, Y., Wang, L., Bell, P., McMenamin, D., He, Z., White, J., Yu, H., Xu, C., Morizono, H., Musunuru, K., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3469 · Cited by 556 · see citing works

Exploring mechanisms of FGF signalling through the lens of structural biology

Goetz, R., & Mohammadi, M. (2013) · Nature reviews. Molecular cell biology · doi:10.1038/nrm3528 · Cited by 556 · see citing works

Functions and regulations of fibroblast growth factor signaling during embryonic development.

Thisse, B., & Thisse, C. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.09.011 · Cited by 554 · see citing works

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

Bookout, A. L., de Groot, M. H. M., Owen, B. M., Lee, S., Gautron, L., Lawrence, H. L., Ding, X., Elmquist, J. K., Takahashi, J. S., Mangelsdorf, D. J., et al. (2013) · Nature Medicine · doi:10.1038/nm.3249 · Cited by 545 · see citing works

Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of Fibroblast Growth Factor 19 Subfamily Members

Goetz, R., Beenken, A., Ibrahimi, O., Kalinina, J., Olsen, S., Eliseenkova, A. V., Xu, C.-F., Neubert, T., Zhang, F.-M., Linhardt, R., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02249-06 · Cited by 544 · see citing works

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

Dutchak, P. A., Katafuchi, T., Bookout, A. L., Choi, J. H., Yu, R. T., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell · doi:10.1016/j.cell.2011.11.062 · Cited by 537 · see citing works

FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss

Owen, B. M., Ding, X., Morgan, D. A., Coate, K. C., Bookout, A. L., Rahmouni, K., Kliewer, S. A., & Mangelsdorf, D. J. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.07.012 · Cited by 523 · see citing works

AZD4547: An Orally Bioavailable, Potent, and Selective Inhibitor of the Fibroblast Growth Factor Receptor Tyrosine Kinase Family

Gavine, P. R., Mooney, L. M., Kilgour, E., Thomas, A. P., Al-Kadhimi, K. J., Beck, S., Rooney, C., Coleman, T., Baker, D., Mellor, M. J., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3034 · Cited by 507 · see citing works

Molecular Signature of Quiescent Satellite Cells in Adult Skeletal Muscle

Fukada, S.-I., Uezumi, A., Ikemoto, M., Masuda, S., Segawa, M., Tanimura, N., Yamamoto, H., Miyagoe-Suzuki, Y., & Takeda, S. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0019 · Cited by 506 · see citing works

Satellite-cell pool size does matter: Defining the myogenic potency of aging skeletal muscle

Shefer, G., de Mark, D. P. V., Richardson, J. B., & Yablonka‐Reuveni, Z. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.02.022 · Cited by 506 · see citing works

Regulation of Fibroblastic Growth Factor 23 Expression but Not Degradation by PHEX

Liu, S., Guo, R., Simpson, L. G., Xiao, Z.-S., Burnham, C. E., & Quarles, L. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304544200 · Cited by 505 · see citing works

Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18.Preprint

Liu, Z.-H., Xu, J.-S., Colvin, J. S., & Ornitz, D. (2002) · Genes & Development · doi:10.1101/gad.965602 · Cited by 501 · see citing works

Transgenic Mice Expressing Fibroblast Growth Factor 23 under the Control of the α1(I) Collagen Promoter Exhibit Growth Retardation, Osteomalacia, and Disturbed Phosphate Homeostasis

Larsson, T. E., Marsell, R., Schipani, E., Ohlsson, C., Ljunggren, Ö., Tenenhouse, H. S., Jüppner, H., & Jonsson, K. B. (2004) · Endocrinology · doi:10.1210/en.2003-1768 · Cited by 497 · see citing works

Pathogenic role of Fgf23 in Hyp mice

Liu, S., Zhou, J., Tang, W., Jiang, X., Rowe, D. W., & Quarles, L. D. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00008.2006 · Cited by 494 · see citing works

α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling

Chen, G., Yang, L., Goetz, R. M., Fu, L., Jayaraman, S., Hu, M. C., Moe, O. W., Liang, G., Li, X., & Mohammadi, M. (2018) · Nature · doi:10.1038/nature25451 · Cited by 491 · see citing works

Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation.

Minina, E., Kreschel, C., Naski, M., Ornitz, D., & Vortkamp, A. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00261-7 · Cited by 489 · see citing works

Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23

White, K. E., Carn, G., Lorenz‐Depiereux, B., Benet‐Pagès, A., Strom, T. M., & Econs, M. J. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00064.x · Cited by 488 · see citing works

FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis.Preprint

Ohbayashi, N., Shibayama, M., Kurotaki, Y., Imanishi, M., Fujimori, T., Itoh, N., & Takada, S. (2002) · Genes & Development · doi:10.1101/gad.965702 · Cited by 487 · see citing works

An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia.

Benet-Pagès, A., Orlik, P., Strom, T., & Lorenz-Depiereux, B. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi034 · Cited by 486 · see citing works

FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung

Weinstein, M. B., Xu, X., Ohyama, K., & Deng, C. (1998) · Development · doi:10.1242/dev.125.18.3615 · Cited by 485 · see citing works

Growth factor control of skeletal muscle differentiation: commitment to terminal differentiation occurs in G1 phase and is repressed by fibroblast growth factor.

Clegg, C. H., Linkhart, T. A., Olwin, B. B., & Hauschka, S. D. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.105.2.949 · Cited by 478 · see citing works

Circulating FGF-23 Is Regulated by 1α,25-Dihydroxyvitamin D3 and Phosphorus in Vivo

Saitô, H., Maeda, A., Ohtomo, S., Hirata, M., Kusano, K., Kato, S., Ogata, E., Segawa, H., Miyamoto, K., & Fukushima, N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408903200 · Cited by 468 · see citing works

Somatic Mutations of the Protein Kinase Gene Family in Human Lung Cancer

Davies, H. R., Hunter, C., Smith, R., Stephens, P., Greenman, C., Bignell, G. R., Teague, J. W., Butler, A. P., Edkins, S., Stevens, C., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1855 · Cited by 464 · see citing works

Functions of Paracrine PDGF Signaling in the Proangiogenic Tumor Stroma Revealed by Pharmacological Targeting

Pietras, K., Pahler, J. C., Bergers, G., & Hanahan, D. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050019 · Cited by 452 · see citing works

Mutant FGF-23 Responsible for Autosomal Dominant Hypophosphatemic Rickets Is Resistant to Proteolytic Cleavage and Causes Hypophosphatemia in Vivo

Shimada, T., Muto, T., Urakawa, I., Yoneya, T., Yamazaki, Y., Okawa, K., Takeuchi, Y., Fujita, T., Fukumoto, S., & Yamashita, T. (2002) · Endocrinology · doi:10.1210/endo.143.8.8795 · Cited by 439 · see citing works

FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1

Gattineni, J., Bates, C. M., Twombley, K. E., Dwarakanath, V. N., Robinson, M. L., Goetz, R. M., Mohammadi, M., & Baum, M. G. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90742.2008 · Cited by 439 · see citing works

Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening

Sawey, E. T., Chanrion, M., Cai, C., Wu, G., Zhang, J., Zender, L., Zhao, A. S., Busuttil, R. W., Yee, H. T., Stein, L. D., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.01.040 · Cited by 437 · see citing works

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

Potthoff, M. J., Boney-Montoya, J., Choi, M., He, T., Sunny, N. E., Satapati, S., Suino-Powell, K., Xu, H. E., Gerard, R. D., Finck, B. N., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.019 · Cited by 431 · see citing works

Evaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation and Dose-Expansion Study

Nogová, L., Sequist, L. V. D., Pérez-García, J. M., André, F., Delord, J., Hidalgo, M. M., Schellens, J. H. M., Cassier, P. A., Camidge, D. R., Schüler, M., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.67.2048 · Cited by 430 · see citing works

FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa

Shimada, T., Urakawa, I., Yamazaki, Y., Hasegawa, H., Hino, R., Yoneya, T., Takeuchi, Y., Fujita, T., Fukumoto, S., & Yamashita, T. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.12.102 · Cited by 429 · see citing works

Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung.

Peters, K. G., Werner, S., Liao, X. C., Wert, S. E., Whitsett, J. A., & Williams, L. T. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06631.x · Cited by 427 · see citing works

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ

Wei, W., Dutchak, P. A., Wang, X., Ding, X., Wang, X., Bookout, A. L., Goetz, R., Mohammadi, M., Gerard, R. D., Dechow, P. C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200797109 · Cited by 426 · see citing works

Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23

Degirolamo, C., Sabbà, C., & Moschetta, A. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.9 · Cited by 424 · cited 1× · see citing works

Eph Receptor Signaling and EphrinsPreprint

Lisabeth, E. M., Falivelli, G., & Pasquale, E. B. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009159 · Cited by 420 · see citing works

Generation of lung organoids from human pluripotent stem cells in vitro

Miller, A. J., Dye, B. R., Ferrer-Torres, D., Hill, D. R., Overeem, A. W., Shea, L. D., & Spence, J. R. (2019) · Nature Protocols · doi:10.1038/s41596-018-0104-8 · Cited by 418 · see citing works

FGF23 neutralization improves chronic kidney disease–associated hyperparathyroidism yet increases mortality

Shalhoub, V., Shatzen, E. M., Ward, S. C., Davis, J., Stevens, J. L., Bi, V., Renshaw, L., Hawkins, N., Wang, W., Chen, C., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61405 · Cited by 417 · see citing works

Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7α‐hydroxylase gene expression†

Song, K., Li, T., Owsley, E., Strom, S. C., & Chiang, J. Y. L. (2008) · Hepatology · doi:10.1002/hep.22627 · Cited by 414 · see citing works

Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo.

Lavine, K. J., Yu, K., White, A. C., Zhang, X.-Q., Smith, C. S., Partanen, J., & Ornitz, D. (2005) · Developmental Cell · doi:10.1016/j.devcel.2004.12.002 · Cited by 414 · see citing works

Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21

Inagaki, T., Lin, V. Y., Goetz, R., Mohammadi, M., Mangelsdorf, D. J., & Kliewer, S. A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.05.006 · Cited by 409 · see citing works

Integration of FGF and TWIST in calvarial bone and suture development

Rice, D. P. C., Åberg, T., Chan, Y.-S., Tang, Z., Kettunen, P. J., Pakarinen, L., Maxson, R. E., & Thesleff, I. (2000) · Development · doi:10.1242/dev.127.9.1845 · Cited by 407 · see citing works

How Cytokine Networks Fuel Inflammation: Toward a cytokine-based disease taxonomy

Schett, G., Elewaut, D., McInnes, I. B., Dayer, J.-M., & Neurath, M. F. (2013) · Nature Medicine · doi:10.1038/nm.3260 · Cited by 406 · see citing works

Cell Adhesion by Integrins

Bachmann, M., Kukkurainen, S., Hytönen, V. P., & Wehrle‐Haller, B. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2018 · Cited by 400 · see citing works

Syndecan-3 and Syndecan-4 Specifically Mark Skeletal Muscle Satellite Cells and Are Implicated in Satellite Cell Maintenance and Muscle Regeneration

Cornelison, D., Filla, M. S., Stanley, H. M., Rapraeger, A. C., & Olwin, B. B. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0416 · Cited by 399 · see citing works

Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice

Falardeau, J., Chung, W. C. J., Beenken, A., Raivio, T., Plummer, L., Sidis, Y., Jacobson-Dickman, E. E., Eliseenkova, A. V., Ma, J., Dwyer, A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34538 · Cited by 397 · see citing works

Fibroblast growth factor 2 control of vascular tone

Zhou, M., Sutliff, R., Paul, R. J., Lorenz, J. N., Hoying, J., Haudenschild, C., Yin, M., Coffin, J., Kong, L.-J., Kranias, E. G., et al. (1998) · Nature Medicine · doi:10.1038/nm0298-201 · Cited by 396 · see citing works

Cadherin Adhesion and Mechanotransduction

Leckband, D. E., & de Rooij, J. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013212 · Cited by 394 · see citing works

Developmental expression of two murine fibroblast growth factor receptors, fig and bek

Orr‐Urtreger, A., Givol, D., Yayon, A., Yarden, Y., & Lonai, P. (1991) · Development · doi:10.1242/dev.113.4.1419 · Cited by 393 · see citing works

Phase I Dose-Escalation Study of JNJ-42756493, an Oral Pan–Fibroblast Growth Factor Receptor Inhibitor, in Patients With Advanced Solid Tumors

Tabernero, J. M., Bahleda, R., Dienstmann, R., Infante, J. R., Mita, A. C., Italiano, A., Calvo, E., Moreno, V., Adamo, B., Gazzah, A., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.60.7341 · Cited by 390 · see citing works

Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation

Goetz, R. M., Nakada, Y., Hu, M. C., Kurosu, H., Wang, L., Nakatani, T., Shi, M., Eliseenkova, A. V., Razzaque, M. S., Moe, O. W., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902006107 · Cited by 383 · see citing works

Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice

Farrow, E., Yu, X., Summers, L. J., Davis, S. I., Fleet, J. C., Allen, M. R., Robling, A. G., Stayrook, K. R., Jideonwo, V. N., Magers, M. J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110905108 · Cited by 380 · see citing works

FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction

Engel, F. B., Hsieh, P. C. H., Lee, R. T., & Keating, M. T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607382103 · Cited by 371 · see citing works

FGF-dependent metabolic control of vascular development

Yu, P., Wilhelm, K., Dubrac, A., Tung, J. K., Alves, T. C., Fang, J. S., Xie, Y., Zhu, J., Chen, Z., Smet, F. D., et al. (2017) · Nature · doi:10.1038/nature22322 · Cited by 366 · see citing works

Fibroblast growth factor receptors as treatment targets in clinical oncology

Katoh, M. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0115-y · Cited by 362 · see citing works

Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth

Fahmy, R. G., Dass, C. R., Sun, L., Chesterman, C. N., & Khachigian, L. M. (2003) · Nature Medicine · doi:10.1038/nm905 · Cited by 361 · see citing works

Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease

Singh, S., Grabner, A., Yanucil, C., Schramm, K. J., Czaya, B. A., Krick, S., Czaja, M. J., Bartz, R., Abraham, R., Marco, G. S. D., et al. (2016) · Kidney International · doi:10.1016/j.kint.2016.05.019 · Cited by 361 · see citing works

Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development

Perantoni, A., Timofeeva, O., Naillat, F., Richman, C., Pajni-Underwood, S., Wilson, C., Vainio, S., Dove, L., & Lewandoski, M. (2005) · Development · doi:10.1242/dev.01945 · Cited by 357 · see citing works

FGF signaling in the developing endochondral skeleton

Ornitz, D. M. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.02.003 · Cited by 355 · see citing works

Sprouty1 regulates reversible quiescence of a self-renewing adult muscle stem cell pool during regeneration

Shea, K. L., Xiang, W., LaPorta, V. S., Licht, J. D., Keller, C., Basson, M. A., & Brack, A. S. (2010) · Cell stem cell · doi:10.1016/j.stem.2009.12.015 · Cited by 351 · see citing works

Effect of Intra-Articular Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With Osteoarthritis

Hochberg, M. C., Guermazi, A., Guehring, H., Aydemir, A., Wax, S. D., Fleuranceau-Morel, P., Bihlet, A. R., Byrjalsen, I., Andersen, J. R., & Eckstein, F. (2019) · JAMA · doi:10.1001/jama.2019.14735 · Cited by 351 · see citing works

Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor

Perera, T. P. S., Jovcheva, E., Mévellec, L., Vialard, J. E., Lange, D. D., Verhulst, T., Paulussen, C., Ven, K. V. D., King, P., Freyne, E. J. E., et al. (2017) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-16-0589 · Cited by 346 · see citing works

Drug-sensitive FGFR2 mutations in endometrial carcinoma

Dutt, A., Salvesen, H. B., Chen, T.-H., Ramos, A. H., Onofrio, R. C., Hatton, C., Nicoletti, R., Winckler, W., Grewal, R., Hanna, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803379105 · Cited by 342 · see citing works

Lung hypoplasia and neonatal death in Fgf9 -null mice identify this gene as an essential regulator of lung mesenchyme

Colvin, J. S., White, A. C., Pratt, S. J. P., & Ornitz, D. M. (2001) · Development · doi:10.1242/dev.128.11.2095 · Cited by 338 · see citing works

Association Between Depression and Mortality in Patients Receiving Long-term Dialysis: A Systematic Review and Meta-analysis

Farrokhi, F., Abedi, N., Beyene, J., Kurdyak, P., & Jassal, S. V. (2014) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2013.08.024 · Cited by 336 · see citing works

STRESS signaling pathways that modulate cardiac myocyte apoptosis

Baines, C. P., & Molkentin, J. D. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.11.004 · Cited by 333 · see citing works

Therapeutic Angiogenesis With Intramuscular NV1FGF Improves Amputation-free Survival in Patients With Critical Limb Ischemia

Nikol, S., Baumgärtner, I., BELLE, E. V., Diehm, C., Visonà, A., Capogrossi, M. C., Ferreira-Maldent, N., Gallino, A., Wyatt, M. G., Wijesinghe, L. D., et al. (2008) · Molecular Therapy · doi:10.1038/mt.2008.33 · Cited by 330 · see citing works

Transgenic Mice Overexpressing Human Fibroblast Growth Factor 23 (R176Q) Delineate a Putative Role for Parathyroid Hormone in Renal Phosphate Wasting Disorders

Bai, X., Miao, D., Li, J., Goltzman, D., & Karaplis, A. C. (2004) · Endocrinology · doi:10.1210/en.2004-0233 · Cited by 329 · see citing works

A role for FGF-6 in skeletal muscle regenerationPreprint

Floß, T., Arnold, H.-H., & Braun, T. W. (1997) · Genes & Development · doi:10.1101/gad.11.16.2040 · Cited by 328 · see citing works

Compensation by Fibroblast Growth Factor 1 (FGF1) Does Not Account for the Mild Phenotypic Defects Observed in FGF2 Null Mice

Miller, D. L., Ortega, S., Bashayan, O., Basch, R. S., & Basilico, C. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.6.2260-2268.2000 · Cited by 326 · see citing works

Therapeutic angiogenesis in cardiovascular disease

Simons, M., & Ware, J. A. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1226 · Cited by 325 · see citing works

Resident c-kit+ cells in the heart are not cardiac stem cells

Sultana, N., Zhang, L., Yan, J., Chen, J., Cai, W., Razzaque, S., Jeong, D., Sheng, W., Bu, L., Xu, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms9701 · Cited by 322 · see citing works

FGF23 regulates renal sodium handling and blood pressure

Andrukhova, O., Slavić, S., Тихоновна, С. А., Zeitz, U., Shalhoub, V., Lanske, B., Pohl, E. E., & Erben, R. G. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201303716 · Cited by 321 · see citing works

Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation.

White, K., Cabral, J., Davis, S. I., Fishburn, T., Evans, W. E., Ichikawa, S., Fields, J., Yu, X.-J., Shaw, N., McLellan, N., et al. (2005) · American Journal of Human Genetics · doi:10.1086/427956 · Cited by 320 · see citing works

Interaction between FGF and BMP signaling pathways regulates development of metanephric mesenchymePreprint

Dudley, A. T., Godin, R. E., & Robertson, E. J. (1999) · Genes & Development · doi:10.1101/gad.13.12.1601 · Cited by 320 · see citing works

Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models

Taylor, J. G., Cheuk, A., Tsang, P. S., Chung, J., Song, Y., Desai, K. D., Yu, Y., Chen, Q., Shah, K. J., Youngblood, V., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39703 · Cited by 317 · see citing works

MyoD−/− Satellite Cells in Single-Fiber Culture Are Differentiation Defective and MRF4 Deficient

Cornelison, D., Olwin, B. B., Rudnicki, M. A., & Wold, B. J. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9682 · Cited by 314 · see citing works

FGF21 as Modulator of Metabolism in Health and Disease

Tezze, C., Romanello, V., & Sandri, M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00419 · Cited by 313 · see citing works

Targeting FGFR with Dovitinib (TKI258): Preclinical and Clinical Data in Breast Cancer

André, F., Bachelot, T., Campone, M., Dalenc, F., Pérez-García, J. M., Hurvitz, S. A., Turner, N. C., Rugo, H. S., Smith, J. W., Deudon, S., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0190 · Cited by 311 · see citing works

Inhibition of Angiogenesis by Thrombospondin-1 Is Mediated by 2 Independent Regions Within the Type 1 Repeats

Iruela‐Arispe, M. L., Lombardo, M., Krutzsch, H. C., Lawler, J., & Roberts, D. D. (1999) · Circulation · doi:10.1161/01.cir.100.13.1423 · Cited by 308 · see citing works

<i>Fgfr1</i> and <i>Fgfr2</i> have distinct differentiation- and proliferation-related roles in the developing mouse skull vault

Iseki, S., Wilkie, A. O. M., & Morriss-Kay, G. M. (1999) · Development · doi:10.1242/dev.126.24.5611 · Cited by 305 · see citing works

Identification of Sef, a novel modulator of FGF signalling

Tsang, M., Friesel, R., Kudoh, T., & Dawid, I. B. (2002) · Nature Cell Biology · doi:10.1038/ncb749 · Cited by 304 · see citing works

CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma.

Trudel, S., Li, Z.-H., Wei, E., Wiesmann, M., Chang, H., Chen, C., Reece, D., Heise, C., & Stewart, A. (2004) · Blood · doi:10.1182/blood-2004-10-3913 · Cited by 302 · see citing works

Heparan Sulfate: Biosynthesis, Structure, and Function

Li, J.-P., & Kusche‐Gullberg, M. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.02.009 · Cited by 302 · see citing works

Abnormal bone growth and selective translational regulation in basic fibroblast growth factor (FGF-2) transgenic mice.

Coffin, J. D., Florkiewicz, R. Z., Neumann, J. C., Mort-Hopkins, T., Dorn, G. W., Lightfoot, P. S., German, R. Z., Howles, P. N., Kier, A. B., & O’Toole, B. A. (1995) · Molecular Biology of the Cell · doi:10.1091/mbc.6.12.1861 · Cited by 301 · see citing works

FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting

Liang, Q., Zhong, L., Zhang, J., Wang, Y., Bornstein, S. R., Triggle, C. R., Ding, H., Lam, K. S. L., & Xu, A. (2014) · Diabetes · doi:10.2337/db14-0541 · Cited by 299 · see citing works

FGF‐20 and DKK1 are transcriptional targets of β‐catenin and FGF‐20 is implicated in cancer and development

Chamorro, M. N., Schwartz, D. R., Vonica, A., Brivanlou, A. H., Cho, K. R., & VARMUS, H. E. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600460 · Cited by 299 · see citing works

Fgf9 and FGF20 maintain the stemness of nephron progenitors in mice and man

Barak, H., Huh, S.-H., Chen, S., Jeanpierre, C., Martinovic, J., Parisot, M., Bôle-Feysot, C., Nitschké, P., Salomon, R., Antignac, C., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.04.018 · Cited by 298 · see citing works

FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival.

Kunii, K., Davis, L., Gorenstein, J., Hatch, H., Yashiro, M., Bacco, A. D., Elbi, C., & Lutterbach, B. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5229 · Cited by 297 · see citing works

Eph Receptors and Ephrins: Therapeutic Opportunities

Barquilla, A., & Pasquale, E. B. (2014) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140226 · Cited by 294 · see citing works

Sef is a spatial regulator for Ras/MAP kinase signaling.

Torii, S., Kusakabe, M., Yamamoto, T., Maekawa, M., & Nishida, E. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.05.019 · Cited by 292 · see citing works

Role of FGF/FGFR signaling in skeletal development and homeostasis: learning from mouse models

Su, N. Y., Jin, M. Y., & Chen, L. (2014) · Bone Research · doi:10.1038/boneres.2014.3 · Cited by 291 · see citing works

FGF Regulates TGF-β Signaling and Endothelial-to-Mesenchymal Transition via Control of let-7 miRNA Expression

Chen, P.-Y., Qin, L., Barnes, C., Charisse, K., Yi, T., Zhang, X., Ali, R., Medina, P. P., Yu, J., Slack, F. J., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.10.021 · Cited by 291 · see citing works

Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis

Nissen, L. J., Cao, R., Hedlund, E., Wang, Z., Zhao, X., Wetterskog, D., Funa, K., Bråkenhielm, E., & Cao, Y. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32479 · Cited by 290 · see citing works

Detection, Characterization, and Inhibition of FGFR–TACC Fusions in IDH Wild-type Glioma

Stefano, A. L. D., Fucci, A., Frattini, V., Labussière, M., Mokhtari, K., Zoppoli, P., Marie, Y., Bruno, A., Boisselier, B., Giry, M., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-2199 · Cited by 289 · see citing works

Identification of a hormonal basis for gallbladder filling

Choi, M., Moschetta, A., Bookout, A., Peng, L., Umetani, M., Holmstrom, S. R., Suino-Powell, K., Xu, H. E., Richardson, J., Gerard, R., et al. (2006) · Nature Medicine · doi:10.1038/nm1501 · Cited by 289 · see citing works

Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats

Sarruf, D. A., Thaler, J. P., Morton, G. J., German, J. P., Fischer, J. D., Ogimoto, K., & Schwartz, M. W. (2010) · Diabetes · doi:10.2337/db09-1878 · Cited by 287 · see citing works

A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis

Jonker, J., Suh, J. M., Atkins, A., Ahmadian, M., Li, P., Whyte, J., He, M., Juguilon, H., Yin, Y.-Q., Phillips, C. T., et al. (2012) · Nature · doi:10.1038/nature10998 · Cited by 286 · see citing works

Antisense targeting of basic fibroblast growth factor and dibroblast growth factor receptor-1 in human melanomas blocks intratumoral angiogenesis and tumor growth

Wang, Y., & Becker, D. (1997) · Nature Medicine · doi:10.1038/nm0897-887 · Cited by 284 · see citing works

Identification of the fibroblast growth factor receptor of Swiss 3T3 cells and mouse skeletal muscle myoblasts

Olwin, B. B., & Hauschka, S. D. (1986) · Biochemistry · doi:10.1021/bi00360a001 · Cited by 284 · see citing works

Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination

Schmahl, J., Kim, Y., Colvin, J. S., Ornitz, D., & Capel, B. (2004) · Development · doi:10.1242/dev.01239 · Cited by 279 · see citing works

Adhesion molecule signalling: not always a sticky business

Cavallaro, U., & Dejana, E. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3068 · Cited by 277 · see citing works

FGF23 signaling impairs neutrophil recruitment and host defense during CKD

Rossaint, J., Oehmichen, J., Aken, H. V., Reuter, S., Pavenstädt, H. J., Meersch, M., Unruh, M. L., & Zarbock, A. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83470 · Cited by 277 · see citing works

Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele.

Bange, J., Prechtl, D., Cheburkin, Y. V., Specht, K., Harbeck, N., Schmitt, M., Knyazeva, T., Müller, S., Gärtner, S., Sures, I., et al. (2002) · PubMed · Cited by 275 · see citing works

Role of heparan sulfate in fibroblast growth factor signalling: a structural view

Pellegrini, L. (2001) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(00)00258-x · Cited by 274 · see citing works

Intraarticular Sprifermin (Recombinant Human Fibroblast Growth Factor 18) in Knee Osteoarthritis: A Randomized, Double‐Blind, Placebo‐Controlled Trial

Lohmander, S. L., Hellot, S., Dreher, D., Krantz, E. F. W., Kruger, D., Guermazi, A., & Eckstein, F. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38614 · Cited by 274 · see citing works

Molecular Mechanisms of Fibroblast Growth Factor Signaling in Physiology and PathologyPreprint

Belov, A. A., & Mohammadi, M. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a015958 · Cited by 272 · see citing works

The p38α/β MAPK functions as a molecular switch to activate the quiescent satellite cell

Jones, N. C., Tyner, K. J., Nibarger, L., Stanley, H. M., Cornelison, D., Fedorov, Y. V., & Olwin, B. B. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200408066 · Cited by 272 · see citing works

Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

Nikolić, M., Caritg, O., Jeng, Q., Johnson, J.-A., Sun, D., Howell, K. J., Brady, J., Laresgoiti, U., Allen, G. E., Butler, R., et al. (2017) · eLife · doi:10.7554/elife.26575 · Cited by 270 · see citing works

FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1 −/− micePreprint

Kratochwil, K., Galcerán, J., Tontsch, S., Roth, W., & Grosschedl, R. (2002) · Genes & Development · doi:10.1101/gad.1035602 · Cited by 270 · see citing works

Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins

Gotoh, N. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00840.x · Cited by 269 · see citing works

FGFR1 Emerges as a Potential Therapeutic Target for Lobular Breast Carcinomas

Reis-Filho, J. S., Simpson, P. T., Turner, N. C., Lambros, M. B., Jones, C., Mackay, A. G., Grigoriadis, A. E., Sarrió, D., Savage, K., Dexter, T., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1164 · Cited by 269 · see citing works

Coordination of Satellite Cell Activation and Self-Renewal by Par-Complex-Dependent Asymmetric Activation of p38α/β MAPK

Troy, A., Cadwallader, A. B., Fedorov, Y., Tyner, K., Tanaka, K. K., & Olwin, B. B. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.05.025 · Cited by 268 · see citing works

Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism

Quarles, L. D. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.218 · Cited by 268 · see citing works

Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism

Miraoui, H., Dwyer, A. A., Sykiotis, G. P., Plummer, L., Chung, W., Feng, B., Beenken, A., Clarke, J., Pers, T. H., Dworzynski, P., et al. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.04.008 · Cited by 267 · see citing works

Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models

Desnoyers, L. R., Pai, R., Ferrando, R., Hotzel, K., Le, T., Ross, J., Carano, R., D'Souza, A., Qing, J., Mohtashemi, I., et al. (2008) · Oncogene · doi:10.1038/sj.onc.1210623 · Cited by 266 · see citing works

Fibroblast growth factor 21 protects the heart from oxidative stress

Planavila, A., Redondo‐Angulo, I., Ribas‐Aulinas, F., Garrabou, G., Casademont, J., Giralt, M., & Villarroya, F. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu263 · Cited by 265 · see citing works

Therapeutic Effects of Anti-FGF23 Antibodies in Hypophosphatemic Rickets/Osteomalacia

Aono, Y., Yamazaki, Y., Yasutake, J., Kawata, T., Hasegawa, H., Urakawa, I., Fujita, T., Wada, M., Yamashita, T., Fukumoto, S., et al. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090509 · Cited by 264 · see citing works

FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis

Steinberg, Z. L., Myers, C., Heim, V. M., Lathrop, C. A., Rebustini, I. T., Stewart, J. S., Larsen, M., & Hoffman, M. P. (2005) · Development · doi:10.1242/dev.01690 · Cited by 264 · see citing works

Fibroblast Growth Factor in the Extracellular Matrix of Dystrophic (mdx) Mouse Muscle

DiMario, J. X., Buffinger, N., Yamada, S., & Strohman, R. C. (1989) · Science · doi:10.1126/science.2717945 · Cited by 262 · see citing works

Fibroblast Growth Factor Receptor 2-IIIb Acts Upstream of Shh and Fgf4 and Is Required for Limb Bud Maintenance but Not for the Induction of Fgf8, Fgf10, Msx1, or Bmp4

Revest, J., Spencer‐Dene, B., Kerr, K., Moerlooze, L. D., Rosewell, I. R., & Dickson, C. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0144 · Cited by 262 · see citing works

FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia

Lan, T., Morgan, D. A., Rahmouni, K., Sonoda, J., Fu, X., Burgess, S. C., Holland, W. L., Kliewer, S. A., & Mangelsdorf, D. J. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.005 · Cited by 261 · see citing works

Fibroblasts: Origins, definitions, and functions in health and disease

Plikus, M. V., Wang, X., Sinha, S., Forte, E., Thompson, S. M., Herzog, E. L., Driskell, R. R., Rosenthal, N. A., Biernaskie, J. A., & Horsley, V. (2021) · Cell · doi:10.1016/j.cell.2021.06.024 · Cited by 1,162 · see citing works

The role of biomarkers in diagnosis of COVID-19 – A systematic review

Kermali, M., Khalsa, R. K., Pillai, K., Ismail, Z., & Harky, A. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117788 · Cited by 685 · see citing works

Molecular targeted therapy for anticancer treatment

Min, H.-Y., & Lee, H.-Y. (2022) · Experimental &amp; Molecular Medicine · doi:10.1038/s12276-022-00864-3 · Cited by 569 · see citing works

Targeting cytokine and chemokine signaling pathways for cancer therapy

Yi, M., Li, T., Niu, M., Zhang, H., Wu, Y., Wu, K., & Dai, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01868-3 · Cited by 491 · see citing works

COVID-19 and multiorgan failure: A narrative review on potential mechanisms

Mokhtari, T., Hassani, F., Ghaffari, N., Ebrahimi, B., Yarahmadi, A., & Hassanzadeh, G. (2020) · Journal of Molecular Histology · doi:10.1007/s10735-020-09915-3 · Cited by 440 · see citing works

The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration

Farooq, M., Khan, A. W., Kim, M., & Choi, S.-D. (2021) · Cells · doi:10.3390/cells10113242 · Cited by 342 · see citing works

Prediction model and risk scores of ICU admission and mortality in COVID-19

Zhao, Z., Chen, A. L., Hou, W., Graham, J. M., Li, H., Richman, P. S., Thode, H. C., Singer, A. J., & Duong, T. Q. (2020) · PLoS ONE · doi:10.1371/journal.pone.0236618 · Cited by 301 · see citing works

Alzheimer’s Disease: An Update and Insights Into Pathophysiology

Abubakar, M. B., Sanusi, K. O., Ugusman, A., Mohamed, W. M. Y., Kamal, H., Ibrahim, N. H., Khoo, C. S., & Kumar, J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.742408 · Cited by 293 · see citing works

PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)

He, M., Cao, C., Ni, Z., Liu, Y., Song, P., Hao, S., He, Y., Sun, X., & Rao, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00999-9 · Cited by 283 · see citing works

Laboratory findings in COVID-19 diagnosis and prognosis

Pourbagheri‐Sigaroodi, A., Bashash, D., Fateh, F., & Abolghasemi, H. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.08.019 · Cited by 242 · see citing works

Role of FGFR3 in bladder cancer: Treatment landscape and future challenges

Ascione, C. M., Napolitano, F., Esposito, D., Servetto, A., Belli, S., Santaniello, A., Scagliarini, S., Crocetto, F., Bianco, R., & Formisano, L. (2023) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2023.102530 · Cited by 223 · see citing works

FGFR-targeted therapeutics: clinical activity, mechanisms of resistance and new directions

Katoh, M., Loriot, Y., Brandi, G., Tavolari, S., Wainberg, Z., & Katoh, M. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-024-00869-z · Cited by 183 · see citing works

Targeting FGFR inhibition in cholangiocarcinoma

Goyal, L., Kongpetch, S., Crolley, V. E., & Bridgewater, J. A. (2021) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2021.102170 · Cited by 183 · see citing works

Clinical treatment of cholangiocarcinoma: an updated comprehensive review

Elvevi, A., Laffusa, A., Scaravaglio, M., Rossi, R. E., Longarini, R., Stagno, A. M., Cristoferi, L., Ciaccio, A., Cortinovis, D. L., Invernizzi, P., et al. (2022) · Annals of Hepatology · doi:10.1016/j.aohep.2022.100737 · Cited by 168 · see citing works

Cell communication and relevant signaling pathways in osteogenesis–angiogenesis coupling

Shu-qing, L., Cai, X., Guo, J., Li, X., Li, W., Liu, Y., & Qi, M. (2025) · Bone Research · doi:10.1038/s41413-025-00417-0 · Cited by 162 · see citing works

New developments in the biology of fibroblast growth factors

Ornitz, D. M., & Itoh, N. (2022) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1549 · Cited by 143 · see citing works

Molecular hybrids: A five-year survey on structures of multiple targeted hybrids of protein kinase inhibitors for cancer therapy

Soltan, O. M., Shoman, M. E., Abdel‐Aziz, S. A., Narumi, A., Konno, H., & Abdel‐Aziz, M. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113768 · Cited by 148 · see citing works

Identification of early neurodegenerative pathways in progressive multiple sclerosis

Kaufmann, M., Schaupp, A.-L., Sun, R., Coscia, F., Dendrou, C. A., Cortés, A., Kaur, G., Evans, H. G., Mollbrink, A., Navarro, J. F., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01097-3 · Cited by 128 · see citing works

Unleashing the potential of combining FGFR inhibitor and immune checkpoint blockade for FGF/FGFR signaling in tumor microenvironment

Ruan, R., Li, L., Li, X., Huang, C., Zhanmin, Z., Zhong, H., Zeng, S., Shi, Q., Yang, X., Zeng, Q., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01761-7 · Cited by 130 · see citing works

Immunopathological similarities between COVID-19 and influenza: Investigating the consequences of Co-infection

Khorramdelazad, H., Kazemi, M. H., Najafi, A., Keykhaee, M., Emameh, R. Z., & Falak, R. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104554 · Cited by 127 · see citing works

FGFR blockade boosts T cell infiltration into triple-negative breast cancer by regulating cancer-associated fibroblasts

Wu, Y., Yi, Z., Li, J., Wei, Y., Feng, R., Liu, J., Huang, J., Chen, Y., Wang, X., Sun, J., et al. (2022) · Theranostics · doi:10.7150/thno.68972 · Cited by 127 · see citing works

Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis

Jing, J., Feng, J., Yuan, Y., Guo, T., Lei, J., Pei, F., Ho, T., & Chai, Y. (2022) · Nature Communications · doi:10.1038/s41467-022-32490-y · Cited by 119 · see citing works

Gasdermin D-mediated metabolic crosstalk promotes tissue repair

Chi, Z., Chen, S., Yang, D., Cui, W., Lu, Y., Wang, Z., Li, M., Yu, W., Zhang, J., Jiang, Y., et al. (2024) · Nature · doi:10.1038/s41586-024-08022-7 · Cited by 116 · see citing works

Astrocytes in Chronic Pain: Cellular and Molecular Mechanisms

Lu, H.-J., & Gao, Y.-J. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-022-00961-3 · Cited by 118 · see citing works

Wound Healing with Electrical Stimulation Technologies: A Review

Cheah, Y. J., Buyong, M. R., & Yunus, M. H. M. (2021) · Polymers · doi:10.3390/polym13213790 · Cited by 111 · see citing works

Hepatocellular carcinoma: signaling pathways, targeted therapy, and immunotherapy

Luo, X., He, X., Zhang, X., Zhao, X., Zhang, Y., Shi, Y., & Hua, S. (2024) · MedComm · doi:10.1002/mco2.474 · Cited by 111 · see citing works

Understanding of sarcopenia: from definition to therapeutic strategies

Kim, J. W., Kim, R., Choi, H., Lee, S., & Bae, G. (2021) · Archives of Pharmacal Research · doi:10.1007/s12272-021-01349-z · Cited by 101 · see citing works

Molecular basis of the potential interaction of SARS-CoV-2 spike protein to CD147 in COVID-19 associated-lymphopenia

Helal, M. A., Shouman, S., Abdelwaly, A., Elmehrath, A. O., Essawy, M., Sayed, S. M., Saleh, A. H., & El‐Badri, N. (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1822208 · Cited by 94 · see citing works

Heparan Sulfate Biosynthesis and Sulfation Profiles as Modulators of Cancer Signalling and Progression

Marques, C., Reis, C. A., Vivès, R. R., & Magalhães, A. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.778752 · Cited by 93 · see citing works

Quantitative characterization of cell niches in spatially resolved omics data

Birk, S., Bonafonte-Pardàs, I., Feriz, A. M., Boxall, A. R., Agirre, E., Memi, F., Maguza, A., Yadav, A., Armingol, E., Fan, R., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02120-6 · Cited by 110 · see citing works

FGF/FGFR-Dependent Molecular Mechanisms Underlying Anti-Cancer Drug Resistance

Szymczyk, J., Służalska, K., Materla, I., Opalinski, L., Otlewski, J., & Zakrzewska, M. (2021) · Cancers · doi:10.3390/cancers13225796 · Cited by 80 · see citing works

Decoding the endometrial niche of Asherman’s Syndrome at single-cell resolution

Santamaría, X., Rosón, B., Pérez-Moraga, R., Venkatesan, N., Pardo‐Figuerez, M., González-Fernández, J., Llera-Oyola, J., Fernández, E., Moreno, I., Salumets, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41656-1 · Cited by 86 · see citing works

Chitosan/Alginate Hydrogel Dressing Loaded FGF/VE-Cadherin to Accelerate Full-Thickness Skin Regeneration and More Normal Skin Repairs

Wei, L., Tan, J., Li, L., Liu, S., Wang, H., Chen, J., Weng, Y., & Liu, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031249 · Cited by 81 · see citing works

MiRNA 24-3p-rich exosomes functionalized DEGMA-modified hyaluronic acid hydrogels for corneal epithelial healing

Sun, X., Song, W., Teng, L., Huang, Y., Liu, J., Peng, Y., Lu, X., Yuan, J., Zhao, X., Zhao, Q., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.07.011 · Cited by 81 · see citing works

OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2

Zhu, Q. N., Fu, Y., Cui, C., Ding, Y., Deng, Z., Ning, C., Hu, F., Qiu, C., Yu, B., Zhou, X., et al. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01354-2 · Cited by 81 · see citing works

Pemigatinib in previously treated solid tumors with activating FGFR1–FGFR3 alterations: phase 2 FIGHT-207 basket trial

Rodon, J. A., Damian, S., Furqan, M., García-Donás, J., Imai, H., Italiano, A., Spanggaard, I., Ueno, M., Yokota, T., Veronese, M. L., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-02934-7 · Cited by 80 · see citing works

Targeting Fibrosis: From Molecular Mechanisms to Advanced Therapies

Di, X., Li, Y., Wei, J., Li, T., & Liao, B. (2024) · Advanced Science · doi:10.1002/advs.202410416 · Cited by 83 · see citing works

FGFR families: biological functions and therapeutic interventions in tumors

Liu, Q., Huang, J., Yan, W., Liu, Z., Liu, S., & Fang, W. (2023) · MedComm · doi:10.1002/mco2.367 · Cited by 77 · see citing works

FGF/FGFR Signaling in Hepatocellular Carcinoma: From Carcinogenesis to Recent Therapeutic Intervention

Wang, Y., Liu, D., Zhang, T., & Xia, L. (2021) · Cancers · doi:10.3390/cancers13061360 · Cited by 76 · see citing works

The emerging role of phosphorus in human health

Bird, R. P., & Eskin, N. A. M. (2021) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2021.02.001 · Cited by 74 · see citing works

Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageing

Navarro, M. N., Heras, M. M. G. D. L., & Mittelbrunn, M. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15477 · Cited by 70 · see citing works

Urinary single-cell sequencing captures kidney injury and repair processes in human acute kidney injury

Klocke, J., Kim, S. J., Skopnik, C. M., Hinze, C., Boltengagen, A., Metzke, D., Grothgar, E., Prskalo, L., Wagner, L. F., Freund, P. A., et al. (2022) · Kidney International · doi:10.1016/j.kint.2022.07.032 · Cited by 69 · see citing works

Acne Transcriptomics: Fundamentals of Acne Pathogenesis and Isotretinoin Treatment

Melnik, B. C. (2023) · Cells · doi:10.3390/cells12222600 · Cited by 82 · see citing works

Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters

Lolansen, S. D., Rostgaard, N., Barbuskaite, D., Capion, T., Olsen, M. H., Nørager, N. H., Vilhardt, F., Andreassen, S. N., Toft‐Bertelsen, T. L., Ye, F., et al. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-022-00360-w · Cited by 67 · see citing works

The function of alternative splicing in the proteome: rewiring protein interactomes to put old functions into new contexts

Kjer-Hansen, P., & Weatheritt, R. J. (2023) · Nature Structural & Molecular Biology · doi:10.1038/s41594-023-01155-9 · Cited by 66 · see citing works

The axis of tumor-associated macrophages, extracellular matrix proteins, and cancer-associated fibroblasts in oncogenesis

Yu, S., Wang, S., Wang, X., & Xu, X. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03518-8 · Cited by 65 · see citing works

Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling

Szybowska, P., Kostas, M., Wesche, J., Haugsten, E. M., & Więdłocha, A. (2021) · Cells · doi:10.3390/cells10061342 · Cited by 61 · see citing works

The role of retinal Müller cells in diabetic retinopathy and related therapeutic advances

Yang, S., Qi, S., & Wang, C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1047487 · Cited by 62 · see citing works

Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance

Edirisinghe, O., Ternier, G., Alraawi, Z., & Kumar, T. K. S. (2024) · Biomolecules · doi:10.3390/biom14121622 · Cited by 60 · see citing works

Implanted synthetic cells trigger tissue angiogenesis through de novo production of recombinant growth factors

Chen, G., Levin, R., Landau, S., Kaduri, M., Adir, O., Ianovici, I., Krinsky, N., Doppelt‐Flikshtain, O., Shklover, J., Shainsky‐Roitman, J., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2207525119 · Cited by 57 · see citing works

Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult Xenopus laevis

Murugan, N. J., Vigran, H. J., Miller, K. A., Golding, A. S., Pham, Q. L., Sperry, M. M., Rasmussen-Ivey, C. R., Kane, A., Kaplan, D. L., & Levin, M. G. (2022) · Science Advances · doi:10.1126/sciadv.abj2164 · Cited by 57 · see citing works

Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS‐CoV ‐2

Gour, A., Manhas, D., Bag, S., Gorain, B., & Nandi, U. (2021) · Phytotherapy Research · doi:10.1002/ptr.7092 · Cited by 57 · see citing works

Neurotrophins and Other Growth Factors in the Pathogenesis of Alzheimer’s Disease

Numakawa, T., & Kajihara, R. (2023) · Life · doi:10.3390/life13030647 · Cited by 57 · see citing works

The state of the art in secondary pharmacology and its impact on the safety of new medicines

Brennan, R., Jenkinson, S. G., Brown, A. J., Delaunois, A. G., Dumotier, B. M., Pannirselvam, M., Rao, M., Ribeiro, L. R., Schmidt, F., Sibony, A., et al. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-00942-3 · Cited by 57 · see citing works

COVID-19 and the Risk of Relapse in Multiple Sclerosis Patients: A Fight with No Bystander Effect?

Etemadifar, M., Sedaghat, N., Aghababaee, A., Kargaran, P. K., Maracy, M. R., Ganjalıkhani-Hakemi, M., Rayani, M., Abhari, A. P., Khorvash, R., Salari, M., et al. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.102915 · Cited by 55 · see citing works

Fibroblast growth factor 18 stimulates the proliferation of hepatic stellate cells, thereby inducing liver fibrosis

Tsuchiya, Y., Seki, T., Kobayashi, K., Komazawa‐Sakon, S., Shichino, S., Nishina, T., Fukuhara, K., Ikejima, K., Nagai, H., Igarashi, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42058-z · Cited by 55 · see citing works

Fibroblast growth factor signaling in macrophage polarization: impact on health and diseases

Shen, L., Li, Y., & Zhao, H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1390453 · Cited by 54 · see citing works

The Extracellular Matrix Stiffening: A Trigger of Prostate Cancer Progression and Castration Resistance?

Luthold, C., Hallal, T., Labbé, D. P., & Bordeleau, F. (2022) · Cancers · doi:10.3390/cancers14122887 · Cited by 59 · see citing works

FGF/FGFR Pathways in Multiple Sclerosis and in Its Disease Models

Rajendran, R., Böttiger, G., Stadelmann, C., Karnati, S., & Berghoff, M. (2021) · Cells · doi:10.3390/cells10040884 · Cited by 53 · see citing works

Signaling Pathways and Potential Therapeutic Strategies in Cardiac Fibrosis

Foucault‐Bertaud, A., Joshkon, A., Heim, X., Bachelier, R., Bardin, N., Leroyer, A. S., & Blot‐Chabaud, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021756 · Cited by 51 · see citing works

Personalized medicine: An alternative for cancer treatment

Singh, D., Dhiman, V. K., Pandey, M., Dhiman, V. K., Sharma, A., Pandey, H., Verma, S. K., & Pandey, R. (2024) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2024.100860 · Cited by 50 · see citing works

Clinical advances and challenges in targeting FGF/FGFR signaling in lung cancer

Peng, M., Deng, J., & Li, X. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02167-9 · Cited by 49 · see citing works

Wnt-TCF7-SOX9 axis promotes cholangiocarcinoma proliferation and pemigatinib resistance in a FGF7-FGFR2 autocrine pathway

Liu, Z., Liu, J., Chen, T., Wang, Y., Shi, A., Li, K., Li, X., Qiu, B., Zheng, L., Zhao, L., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02313-x · Cited by 49 · see citing works

Ang II (Angiotensin II)–Induced FGFR1 (Fibroblast Growth Factor Receptor 1) Activation in Tubular Epithelial Cells Promotes Hypertensive Kidney Fibrosis and Injury

Xu, Z., Luo, W., Chen, L., Zhuang, Z., Yang, D., Qian, J., Khan, Z. A., Guan, X., Wang, Y., Li, X., et al. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.18657 · Cited by 48 · see citing works

FGF-based drug discovery: advances and challenges

Chen, G., Chen, L., Li, X., & Mohammadi, M. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01125-w · Cited by 51 · see citing works

Functional Roles of FGF Signaling in Early Development of Vertebrate Embryos

Kumar, V., Goutam, R. S., Park, S., Lee, U., & Kim, J. (2021) · Cells · doi:10.3390/cells10082148 · Cited by 46 · see citing works

The Coevolution of Placentation and Cancer

Wagner, G. P., Gupta, K., Dighe, A., & Levchenko, A. (2021) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-020420-031544 · Cited by 45 · see citing works

Engineered autocrine signaling eliminates muscle cell FGF2 requirements for cultured meat production

Stout, A. J., Zhang, X., Letcher, S. M., Rittenberg, M. L., Shub, M., Chai, K. M., Kaul, M., & Kaplan, D. L. (2024) · Cell Reports Sustainability · doi:10.1016/j.crsus.2023.100009 · Cited by 45 · see citing works

The contributory role of lymphocyte subsets, pathophysiology of lymphopenia and its implication as prognostic and therapeutic opportunity in COVID-19

Delshad, M., Tavakolinia, N., Pourbagheri‐Sigaroodi, A., Safaroghli‐Azar, A., Bagheri, N., & Bashash, D. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107586 · Cited by 45 · see citing works

Eye on the horizon: The metabolic landscape of the RPE in aging and disease

Hansman, D., Du, J., Casson, R. J., & Peet, D. J. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101306 · Cited by 48 · see citing works

Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities

Desai, P. A., Takahashi, N., Kumar, R., Nichols, S., Malin, J., Hunt, A. L., Schultz, C. W., Cao, Y., Tillo, D., Nousome, D., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101610 · Cited by 43 · see citing works

FGFR3 alterations in bladder cancer: Sensitivity and resistance to targeted therapies

Noeraparast, M., Krajina, K., Pichler, R., Niedersüß-Beke, D., Shariat, S., Grünwald, V., Ahyai, S., & Pichler, M. (2024) · Cancer Communications · doi:10.1002/cac2.12602 · Cited by 45 · see citing works

Role and Therapeutic Potential for Targeting Fibroblast Growth Factor 10/ FGFR1 in Relapsed Rheumatoid Arthritis

Meng, X., Chen, Z., Li, T., Nie, Z., Han, H., Zhong, S., Yin, Z., Sun, S., Xie, J., Shen, J., et al. (2023) · Arthritis & Rheumatology · doi:10.1002/art.42674 · Cited by 44 · see citing works

Effects and action mechanisms of individual cytokines contained in PRP on osteoarthritis

Wang, Z., Zhu, P., Liao, B., You, H., & Cai, Y. (2023) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-023-04119-3 · Cited by 43 · see citing works

Covid-19 rapid test by combining a Random Forest-based web system and blood tests

Barbosa, V. A. D. F., Gomes, J. C., de Santana, M. A., de Lima, C. L., Calado, R. B., Júnior, C. R. B., Albuquerque, J. E. D. A., de Souza, R. G., de Araújo, R. J. E., Júnior, L. A. R. M., et al. (2021) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2021.1966509 · Cited by 42 · see citing works

Single-nucleotide variants within heart enhancers increase binding affinity and disrupt heart development

Jindal, G. A., Bantle, A., Solvason, J. J., Grudzien, J. L., D’Antonio‐Chronowska, A., Lim, F., Le, S. H., Song, B. P., Ragsac, M. F., Klie, A., et al. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.09.005 · Cited by 41 · see citing works

Transcriptional regulation of cancer stem cell: regulatory factors elucidation and cancer treatment strategies

Zhang, Z., & Zhang, Y. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03021-y · Cited by 40 · see citing works

New insights into the role of Klotho in inflammation and fibrosis: molecular and cellular mechanisms

Zhao, X., Han, D., Zhao, C., Yang, F., Wang, Z., Gao, Y., Jin, M., & Tao, R. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1454142 · Cited by 49 · see citing works

Regenerative potential of PRP-based scaffolds in chronic wound healing: Mechanisms, advances, and therapeutic insights

Altalbawy, F. M. A., mukhlif, B. A., Hussen, A., Mohammed, J. S., Renuka Jyothi, S., Singh, A., Mishra, S. B., Chauhan, A. S., Astaneh, M. E., & Fereydouni, N. (2025) · Regenerative Therapy · doi:10.1016/j.reth.2025.06.008 · Cited by 40 · see citing works

Emerging Importance of Tyrosine Kinase Inhibitors against Cancer: Quo Vadis to Cure?

Mongre, R. K., Mishra, C. B., Shukla, A. K., Prakash, A., Jung, S., Ashraf-Uz-Zaman, M., & Lee, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111659 · Cited by 40 · see citing works

Anti-angiogenic therapy in ovarian cancer: Current understandings and prospects of precision medicine

Mei, C., Gong, W., Wang, X., Lv, Y., Zhang, Y., Wu, S., & Zhu, C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1147717 · Cited by 39 · see citing works

FGFR Inhibition in Urothelial Carcinoma

Li, R., Linscott, J. A., Catto, J. W. F., Daneshmand, S., Faltas, B. M., Kamat, A. M., Meeks, J. J., Necchi, A., Pradère, B., Ross, J. S., et al. (2024) · European Urology · doi:10.1016/j.eururo.2024.09.012 · Cited by 39 · see citing works

Emerging biosensing platforms for quantitative detection of exosomes as diagnostic biomarkers

Tan, J., Wen, Y., & Li, M. (2021) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2021.214111 · Cited by 38 · see citing works

Targeting Lymphangiogenesis and Lymph Node Metastasis in Liver Cancer

Roy, S., Banerjee, P., Ekser, B., Bayless, K. J., Zawieja, D. C., Alpini, G. D., Glaser, S. S., & Chakraborty, S. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.08.011 · Cited by 38 · see citing works

Molecularly Targeted Therapy towards Genetic Alterations in Advanced Bladder Cancer

Thomas, J. V., & Sonpavde, G. (2022) · Cancers · doi:10.3390/cancers14071795 · Cited by 38 · see citing works

Fibroblast growth factor 21 in metabolic syndrome

Yang, M., Liu, C., Jiang, N., Liu, Y., Luo, S., Li, C., Zhao, H., Han, Y., Chen, W., Li, L., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1220426 · Cited by 39 · see citing works

Growth factors in the treatment of Achilles tendon injury

Lin, M., Li, W., Ni, X., Yu, S., Li, H., Chen, X., Lu, Y., Jiang, M., & Wang, C. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1250533 · Cited by 37 · see citing works

Antiangiogenic Strategies in Epithelial Ovarian Cancer: Mechanism, Resistance, and Combination Therapy

Jin, C., Yuan, M., Bu, H., & Jin, C. (2022) · Journal of Oncology · doi:10.1155/2022/4880355 · Cited by 37 · see citing works

FGF8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma

Hao, Y., Xiao, Y., Liao, X., Tang, S., Xie, X., Liu, R. R., & Chen, Q. (2021) · International Journal of Oral Science · doi:10.1038/s41368-021-00111-x · Cited by 36 · see citing works

FGF7/FGFR2–JunB signalling counteracts the effect of progesterone in luminal breast cancer

Mieczkowski, K., Kitowska, K., Braun, M., Galikowska-Bogut, B., Gorska-Arcisz, M., Piasecka, D., Stawiski, K., Żaczek, A., Nejc, D., Kordek, R., et al. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13274 · Cited by 20 · see citing works

Discovery of TYRA-300: First Oral Selective FGFR3 Inhibitor for the Treatment of Urothelial Cancers and Achondroplasia.

Hudkins, R., Allen, E. L., Balcer, A., Hoffman, I., Iyer, S., Neal, M., Nelson, K., Rideout, M., Ye, Q., Starrett, J. H., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c01531 · Cited by 35 · see citing works

EPS364, a Novel Deep-Sea Bacterial Exopolysaccharide, Inhibits Liver Cancer Cell Growth and Adhesion

Wang, Y., Liu, G., Liu, R., Wei, M., Zhang, J., & Sun, C. (2021) · Marine Drugs · doi:10.3390/md19030171 · Cited by 34 · see citing works

Peptide ligands targeting FGF receptors promote recovery from dorsal root crush injury via AKT/mTOR signaling

Zhao, Y., Wang, Q., Xie, C., Cai, Y., Chen, X., Hou, Y., He, L., Li, J., Yao, M., Chen, S., et al. (2021) · Theranostics · doi:10.7150/thno.62525 · Cited by 34 · see citing works

Neurodevelopmental disorders, immunity, and cancer are connected

Nussinov, R., Tsai, C., & Jang, H. (2022) · iScience · doi:10.1016/j.isci.2022.104492 · Cited by 34 · see citing works

Phase I study of the irreversible fibroblast growth factor receptor 1–4 inhibitor futibatinib in Japanese patients with advanced solid tumors

Doi, T., Shitara, K., Kojima, T., Kuboki, Y., Matsubara, N., Bando, H., Yoh, K., Naito, Y., Hirai, H., Kurokawa, Y., et al. (2022) · Cancer Science · doi:10.1111/cas.15486 · Cited by 34 · see citing works

FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3

Jiang, H., Fang, Y., Wang, Y., Li, T., Lin, H., Lin, J., Pan, T., Liu, Q., Lv, J., Chen, D., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109762 · Cited by 34 · see citing works

Biological and clinical implications of FGFR aberrations in paediatric and young adult cancers

Brown, L. M., Ekert, P. G., & Fleuren, E. D. G. (2023) · Oncogene · doi:10.1038/s41388-023-02705-7 · Cited by 34 · see citing works

Residue-Selective Inhibitors Discovery via Covalent DNA-Encoded Chemical Libraries with Diverse Warheads

Wu, X., Pan, J., Fan, R., Zhang, Y., Wang, C., Wang, G., Liu, J., Cui, M., Yue, J., Jin, R., et al. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c01712 · Cited by 34 · see citing works

Racial Disparities in Pathological Complete Response Among Patients Receiving Neoadjuvant Chemotherapy for Early-Stage Breast Cancer

Zhao, F., Miyashita, M., Hattori, M., Yoshimatsu, T. F., Howard, F. M., Kaneva, K., Jones, R., Bell, J. S. K., Fleming, G. F., Jaskowiak, N. T., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.3329 · Cited by 33 · see citing works

Targeting Drugs Against Fibroblast Growth Factor(s)-Induced Cell Signaling

Agrawal, S., Maity, S., Alraawi, Z., Al-Ameer, M., & Kumar, T. K. S. (2020) · Current Drug Targets · doi:10.2174/1389450121999201012201926 · Cited by 34 · see citing works

Perspective Chapter: FGF/FGFR Signaling in Disease Pathogenesis

Qi, X., Geng, X., & Wu, H. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1015716

Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction

Carter, E. P., Fearon, A. E., & Grose, R. P. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.11.003 · Cited by 147 · see citing works

Advances in FGF/FGFR Signaling: Implications for Disease and Therapy

Song, M., Liu, X., Xiao, Y., Li, Y., & Zhao, H. (2026) · MedComm · doi:10.1002/mco2.70922

Fibroblast growth factor and kidney disease: Updates for emerging novel therapeutics

Trivedi, N., & Kumar, D. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30497 · Cited by 2 · see citing works