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A 5S rRNA/L5 complex is a precursor to ribosome assembly in mammalian cells.
Open accessAbstract
A novel 5S RNA-protein (RNP) complex in human and mouse cells has been analyzed using patient autoantibodies. The RNP is small (approximately 7S) and contains most of the nonribosome-associated 5S RNA molecules in HeLa cells. The 5S RNA in the particle is matured at its 3' end, consistent with the results of in vivo pulse-chase experiments which indicate that this RNP represents a later step in 5S biogenesis than a previously described 5S*/La protein complex. The protein moiety of the 5S RNP has been identified as ribosomal protein L5, which is known to be released from ribosomes in a complex with 5S after various treatments of the 60S subunit. Indirect immunofluorescence indicates that the L5/5S complex is concentrated in the nucleolus. L5 may therefore play a role in delivering 5S rRNA to the nucleolus for assembly into ribosomes.
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Metadata
- Authors
- Steitz, J. A., Berg, C., Hendrick, J. P., La Branche-Chabot, H., Metspalu, A., Rinke, J., & Yario, T.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1988-03-01
- Volume
- 106
- Issue
- 3
- Pages
- 545-556
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2148829991
- Cited by
- 171
- References
- 0
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A 5S rRNA/L5 complex is a precursor to ribosome assembly in mammalian cells. https://app.cochat.ai/papers/10.1083/jcb.106.3.545
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- Steitz, J. A., Berg, C., Hendrick, J. P., La Branche-Chabot, H., Metspalu, A., Rinke, J., & Yario, T. (1988). A 5S rRNA/L5 complex is a precursor to ribosome assembly in mammalian cells. The Journal of cell biology. https://doi.org/10.1083/jcb.106.3.545
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
