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Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate.
Open accessAbstract
The folate receptor is a glycosyl-phosphatidylinositol (GPI)-anchored membrane protein that mediates the delivery of 5-methyltetrahydrofolate to the cytoplasm of MA104 cells. Ordinarily the receptor is sequestered into numerous discrete clusters that are associated with an uncoated pit membrane specialization called a caveola. By using two different methodological approaches, we found that the maintenance of both receptor clusters and caveolae depends upon the presence of cholesterol in the membrane. These results suggest that cholesterol plays a critical role in maintaining the caveola membrane domain and modulates the interaction of GPI-anchored membrane proteins via their phospholipid anchors.
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Citations
Cited by
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Role for Human Immunodeficiency Virus Type 1 Membrane Cholesterol in Viral Internalization
Guyader, M., Kiyokawa, E., Abrami, L., Turelli, P., & Trono, D. (2002) · Journal of Virology · doi:10.1128/jvi.76.20.10356-10364.2002 · Cited by 170
Takeshita, N., Higashitsuji, Y., Konzack, S., & Fischer, R. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-06-0523 · Cited by 163
Candela, P., Gosselet, F., Miller, F., Buee-Scherrer, V., Torpier, G., Cecchelli, R., & Fenart, L. (2008) · Endothelium · doi:10.1080/10623320802487759 · Cited by 117
Metadata
- Authors
- Rothberg, K. G., Ying, Y. S., Kamen, B. A., & Anderson, R. G.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1990-12-01
- Volume
- 111
- Issue
- 6
- Pages
- 2931-2938
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2068418997
- Cited by
- 532
- References
- 0
- FWCI
- 7.16
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate. https://app.cochat.ai/papers/10.1083/jcb.111.6.2931
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- Rothberg, K. G., Ying, Y. S., Kamen, B. A., & Anderson, R. G. (1990). Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate. The Journal of cell biology. https://doi.org/10.1083/jcb.111.6.2931
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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