The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Transforming growth factor-beta 1 in the rat brain: increase after injury and inhibition of astrocyte proliferation
Open accessAbstract
Transforming growth factor-beta 1 (TGF-beta 1) has been shown to up-regulate the synthesis of nerve growth factor (NGF) in cultured rat astrocytes and in neonatal brain in vivo (Lindholm, D., B. Hengerer, F. Zafra, and H. Thoenen. 1990. NeuroReport. 1:9-12). Here we show that mRNA encoding TGF-beta 1 increased in rat cerebral cortex after a penetrating brain injury. The level of NGF mRNA is also transiently increased after the brain trauma, whereas that of brain-derived neurotrophic factor remained unchanged. In situ hybridization experiments showed a strong expression of TGF-beta 1 4 d after the lesion in cells within and in the vicinity of the wound. Staining of adjacent sections with OX-42 antibodies, specific for macrophages and microglia/brain macrophages, revealed a similar pattern of positive cells, suggesting that invading macrophages, and perhaps reactive microglia, are the source of TGF-beta 1 in injured brain. Both astrocytes and microglia express TGF-beta 1 in culture, and TGF-beta 1 mRNA levels in astrocytes are increased by various growth factors, including FGF, EGF, and TGF-beta itself. TGF-beta 1 is a strong inhibitor of astrocyte proliferation and suppresses the mitotic effects of FGF and EGF on astrocytes. The present results indicate that TGF-beta 1 expressed in the lesioned brain plays a role in nerve regeneration by stimulating NGF production and by controlling the extent of astrocyte proliferation and scar formation.
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Cites
Zafra, F., Hengerer, B., Leibrock, J., Thoenen, H., & Lindholm, D. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07564.x · Cited by 897
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Metadata
- Authors
- Lindholm, D., Castrén, E., Kiefer, R., Zafra, F., & Thoenen, H.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1992-04-15
- Volume
- 117
- Issue
- 2
- Pages
- 395-400
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2106829291
- Cited by
- 487
- References
- 1
- FWCI
- 32.45
- Type
- journal article
- Language
- en
- Open access
- green
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- Lindholm, D., Castrén, E., Kiefer, R., Zafra, F., & Thoenen, H. (1992). Transforming growth factor-beta 1 in the rat brain: increase after injury and inhibition of astrocyte proliferation. The Journal of cell biology. https://doi.org/10.1083/jcb.117.2.395
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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