Cited by 1,337Liver physiology and pathologyAngiogenesis and VEGF in CancerFibroblast Growth Factor Research

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Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth.

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Bussolino, F, Di Renzo, M F, Ziche, M, Bocchietto, E, Olivero, M, Naldini, L, Gaudino, G, Tamagnone, L, Coffer, A, Comoglio, P M·1992·The Journal of cell biology

DOI 10.1083/jcb.119.3.629PMC PMC2289675

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Abstract

Hepatocyte Growth Factor (HGF, also known as Scatter Factor) is a powerful mitogen or motility factor in different cells, acting through the tyrosine kinase receptor encoded by the MET protooncogene. Endothelial cells express the MET gene and expose at the cell surface the mature protein (p190MET) made of a 50 kD (alpha) subunit disulfide linked to a 145-kD (beta) subunit. HGF binding to endothelial cells identifies two sites with different affinities. The higher affinity binding site (Kd = 0.35 nM) corresponds to the p190MET receptor. Sub-nanomolar concentrations of HGF, but not of a recombinant inactive precursor, stimulate the receptor kinase activity, cell proliferation and motility. HGF induces repairs of a wound in endothelial cell monolayer. HGF stimulates the scatter of endothelial cells grown on three-dimensional collagen gels, inducing an elongated phenotype. In the rabbit cornea, highly purified HGF promotes neovascularization at sub-nanomolar concentrations. HGF lacks activities related to hemostasis-thrombosis, inflammation and endothelial cells accessory functions. These data show that HGF is an in vivo potent angiogenic factor and in vitro induces endothelial cells to proliferate and migrate.

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Authors: Bussolino, F., Di Renzo, M. F., Ziche, M., Bocchietto, E., Olivero, M., Naldini, L., Gaudino, G., Tamagnone, L., Coffer, A., & Comoglio, P. M.
Affiliations: University of Turin (IT)
Department of Genetics, Biology and Medical Chemistry, University of Torino.
ORCID: Bussolino, F
Ziche, M
Olivero, M
Naldini, L
Gaudino, G
Tamagnone, L
Comoglio, P M
Venue: The Journal of cell biology
Publisher: Rockefeller University Press
Published: 1992-11-01
Volume: 119
Issue: 3
Pages: 629-641
ISSN: 0021-9525 (ISSN-L)
1540-8140
DOI: 10.1083/jcb.119.3.629
PMC: PMC2289675
OpenAlex: W2035174231
Cited by: 1,337
References: 78
Citations by year: 2026: 8 · 2025: 11 · 2024: 20 · 2023: 13 · 2022: 19 · 2021: 24 · 2020: 27 · 2019: 22 · 2018: 38 · 2017: 30 · 2016: 40 · 2015: 47 · 2014: 50 · 2013: 50 · 2012: 47
FWCI: 22.99
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc-sa
Locations: The Journal of Cell Biology (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Use Siena air (University of Siena) (submittedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Keywords: hepatocyte growth factor, angiogenesis, endothelial cell motility, endothelial cell proliferation, c-Met, receptor tyrosine kinase, receptor binding affinity, wound healing, neovascularization, cornea, cell migration
MeSH terms: Animals, Cell Line, Cell Movement, Cells, Cultured, Cornea, Endothelium, Vascular, Humans, Kinetics, Neovascularization, Pathologic, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Proto-Oncogenes, Rabbits, Recombinant Proteins, Umbilical Veins, Wound Healing, Mutagenesis, Site-Directed, Hepatocyte Growth Factor, Proto-Oncogene Proteins c-met, Macromolecular Substances, Mice

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Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth.

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