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Dictyostelium mutants lacking the cytoskeletal protein coronin are defective in cytokinesis and cell motility.
Open accessAbstract
Coronin is an actin-binding protein in Dictyostelium discoideum that is enriched at the leading edge of the cells and in projections of the cell surface called crowns. The polypeptide sequence of coronin is distinguished by its similarities to the beta-subunits of trimeric G proteins (E. L. de Hostos, B. Bradtke, F. Lottspeich, R. Guggenheim, and G. Gerisch, 1991. EMBO (Eur. Mol. Biol. Organ.) J. 10:4097-4104). To elucidate the in vivo function of coronin, null mutants have been generated by gene replacement. The mutant cells lacking coronin grow and migrate more slowly than wild-type cells. When these cor- cells grow in liquid medium they become multinucleate, indicating a role of coronin in cytokinesis. To explore this role, coronin has been localized in mitotic wild-type cells by immunofluorescence labeling. During separation of the daughter cells, coronin is strongly accumulated at their distal portions including the leading edges. This contrasts with the localization of myosin II in the cleavage furrow and suggests that coronin functions independently of the conventional myosin in facilitating cytokinesis.
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Citations
Cited by
A Coat Protein on Phagosomes Involved in the Intracellular Survival of Mycobacteria
Ferrari, G., Langen, H., Naito, M., & Pieters, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80754-0 · Cited by 580
Maniak, M., Rauchenberger, R., Albrecht, R., Murphy, J., & Gerisch, G. (1995) · Cell · doi:10.1016/0092-8674(95)90207-4 · Cited by 354
Self-citationSurvival of Mycobacteria in Macrophages Is Mediated by Coronin 1-Dependent Activation of Calcineurin
Jayachandran, R., Sundaramurthy, V., Combaluzier, B., Mueller, P., Korf, H., Huygen, K., Miyazaki, T., Albrecht, I., Massner, J., & Pieters, J. (2007) · Cell · doi:10.1016/j.cell.2007.04.043 · Cited by 310
Requirement for Coronin 1 in T Lymphocyte Trafficking and Cellular Homeostasis
Föger, N., Rangell, L., Danilenko, D. M., & Chan, A. C. (2006) · Science · doi:10.1126/science.1130563 · Cited by 272
Ahmed, Z., Shaw, G., Sharma, V. P., Yang, C., McGowan, E., & Dickson, D. W. (2007) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.6a7156.2007 · Cited by 258
Metadata
- Authors
- de Hostos, E. L., Rehfuess, C., Bradtke, B., Waddell, D. R., Albrecht, R., Murphy, J., & Gerisch, G.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1993-01-01
- Volume
- 120
- Issue
- 1
- Pages
- 163-173
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2111531358
- Cited by
- 250
- References
- 0
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- green
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- de Hostos, E. L., Rehfuess, C., Bradtke, B., Waddell, D. R., Albrecht, R., Murphy, J., & Gerisch, G. (1993). Dictyostelium mutants lacking the cytoskeletal protein coronin are defective in cytokinesis and cell motility. The Journal of cell biology. https://doi.org/10.1083/jcb.120.1.163
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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