The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Requirement for Coronin 1 in T Lymphocyte Trafficking and Cellular Homeostasis
Abstract
The evolutionarily conserved actin-related protein (Arp2/3) complex is a key component of actin filament networks that is dynamically regulated by nucleation-promoting and inhibitory factors. Although much is known about actin assembly, the physiologic functions of inhibitory proteins are unclear. We generated coronin 1 –/– mice and found that coronin 1 exerted an inhibitory effect on cellular steady-state F-actin formation via an Arp2/3-dependent mechanism. Whereas coronin 1 was required for chemokine-mediated migration, it was dispensable for T cell antigen receptor functions in T cells. Moreover, actin dynamics, through a mitochondrial pathway, was linked to lymphocyte homeostasis.
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Cites
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Cited by
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Survival of Mycobacteria in Macrophages Is Mediated by Coronin 1-Dependent Activation of Calcineurin
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The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans
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Metadata
- Authors
- Föger, N., Rangell, L., Danilenko, D. M., & Chan, A. C.
- Venue
- Science
- Published
- 2006-08-11
- Volume
- 313
- Issue
- 5788
- Pages
- 839-842
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1965572078
- Cited by
- 272
- References
- 25
- FWCI
- 7.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Föger, N., Rangell, L., Danilenko, D. M., & Chan, A. C. (2006). Requirement for Coronin 1 in T Lymphocyte Trafficking and Cellular Homeostasis. Science. https://doi.org/10.1126/science.1130563
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
