The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation
Open accessAbstract
Thyroid hormones play an important role in brain development, but the mechanism(s) by which triiodothyronine (T3) mediates neuronal differentiation is poorly understood. Here we demonstrate that T3 regulates the neurotrophic factor, neurotrophin-3 (NT-3), in developing rat cerebellar granule cells both in cell culture and in vivo. In situ hybridization experiments showed that developing Purkinje cells do not express NT-3 mRNA but do express trkC, the putative neuronal receptor for NT-3. Addition of recombinant NT-3 to cerebellar cultures from embryonic rat brain induces hypertrophy and neurite sprouting of Purkinje cells, and upregulates the mRNA encoding the calcium-binding protein, calbindin-28 kD. The present study demonstrates a novel interaction between cerebellar granule neurons and developing Purkinje cells in which NT-3 induced by T3 in the granule cells promotes Purkinje cell differentiation.
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Cites
Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF
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Self-citationErnfors, P., Ibáñez, C. F., Ebendal, T., Olson, L., & Persson, H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.14.5454 · Cited by 700
Light regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex.
Castrén, E., Zafra, F., Thoenen, H., & Lindholm, D. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.20.9444 · Cited by 513
Self-citationDepolarizing stimuli regulate nerve growth factor gene expression in cultured hippocampal neurons.
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Cited by
Neurotrophins and Neuronal Plasticity
Thoenen, H. (1995) · Science · doi:10.1126/science.270.5236.593 · Cited by 1,927
Self-citationMolecular Basis of Thyroid Hormone-Dependent Brain Development*
Oppenheimer, J. H., & Schwartz, H. L. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.4.0309 · Cited by 517
Influence of maternal thyroid hormones during gestation on fetal brain development
Moog, N. K., Entringer, S., Heim, C., Wadhwa, P. D., Kathmann, N., & Buss, C. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.070 · Cited by 474
Action of thyroid hormone in brain
Bernal, J. (2002) · Journal of Endocrinological Investigation · doi:10.1007/bf03344003 · Cited by 358
Thyroid Hormone Action and Brain Development
Koibuchi, N., & Chin, W. W. (2000) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(00)00238-1 · Cited by 329
Metadata
- Authors
- Lindholm, D., Castrén, E., Tsoulfas, P., Kolbeck, R., Berzaghi, M. D. P., Leingärtner, A., Heisenberg, C., Tessarollo, L., Parada, L., Thoenen, H., & Tesarollo, L.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1993-07-15
- Volume
- 122
- Issue
- 2
- Pages
- 443-450
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2148601264
- Cited by
- 181
- References
- 7
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation. https://app.cochat.ai/papers/10.1083/jcb.122.2.443
- The paper
- Lindholm, D., Castrén, E., Tsoulfas, P., Kolbeck, R., Berzaghi, M. D. P., Leingärtner, A., Heisenberg, C., Tessarollo, L., Parada, L., Thoenen, H., & Tesarollo, L. (1993). Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation. The Journal of cell biology. https://doi.org/10.1083/jcb.122.2.443
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
