Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 517

The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.

Molecular Basis of Thyroid Hormone-Dependent Brain Development*

Oppenheimer, Jack H., Schwartz, Harold L.·1997·Endocrine Reviews
DOI 10.1210/edrv.18.4.0309
Open this paper in CoChat — free account

Abstract

SOME 108 yr have passed since a committee of the Clinical Society of London stressed the important role of the thyroid gland in assuring normal brain development (1). Members of that committee drew this conclusion from the observation that patients with both sporadic and endemic cretinism clearly showed evidence of mental retardation. Subsequent clinical experience emphasized the importance of making the diagnosis of congenital hypothyroidism and initiating appropriate replacement treatment as soon as possible after birth. With the development of sensitive thyroid function screening tests (2–4) it became possible to identify congenital hypothyroidism at birth and to start treatment without delay (5). However, the persistence of iodine deficiency in many areas of the developing world still presents an important problem and has raised the possibility that even minimal degrees of undetected hypothyroidism in infants born in such iodine-deficient regions lead to suboptimal intellectual development (6, 7). Further, an understanding of the role of thyroid hormone in terminal brain differentiation may provide insights into the mechanisms by which other metabolic and nutritional factors influence this process. These considerations have stimulated renewed interest in the molecular basis of thyroid hormone-dependent brain development.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1210/edrv.18.4.0309

Cites

116 of 116 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 116 references

Cited by

See all 517

Metadata

Authors
Oppenheimer, J. H., & Schwartz, H. L.
Venue
Endocrine Reviews
Publisher
The Endocrine Society
Published
1997-08-01
Volume
18
Issue
4
Pages
462-475
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
DOI
10.1210/edrv.18.4.0309
OpenAlex
W2033638549
Cited by
517
References
116
FWCI
13.49
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Molecular Basis of Thyroid Hormone-Dependent Brain Development*. https://app.cochat.ai/papers/10.1210/edrv.18.4.0309
The paper
Oppenheimer, J. H., & Schwartz, H. L. (1997). Molecular Basis of Thyroid Hormone-Dependent Brain Development*. Endocrine Reviews. https://doi.org/10.1210/edrv.18.4.0309

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.