The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Cell nucleus and DNA fragmentation are not required for apoptosis.
Open accessAbstract
Apoptosis is the predominant form of cell death and occurs under a variety of physiological and pathological conditions. Cells undergoing apoptotic cell death reveal a characteristic sequence of cytological alterations including membrane blebbing and nuclear and cytoplasmic condensation. Activation of an endonuclease which cleaves genomic DNA into internucleosomal DNA fragments is considered to be the hallmark of apoptosis. However, no clear evidence exists that DNA degradation plays a primary and causative role in apoptotic cell death. Here we show that cells enucleated with cytochalasin B still undergo apoptosis induced either by treatment with menadione, an oxidant quinone compound, or by triggering APO-1/Fas, a cell surface molecule involved in physiological cell death. Incubation of enucleated cells with the agonistic monoclonal anti-APO-1 antibody revealed the key morphological features of apoptosis. Moreover, in non-enucleated cells inhibitors of endonuclease blocked DNA fragmentation, but not cell death induced by anti-APO-1. These data suggest that DNA degradation and nuclear signaling are not required for induction of apoptotic cell death.
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Cites
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Cited by
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Ischemic Cell Death in Brain Neurons
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Metadata
- Authors
- Schulze-Osthoff, K., Walczak, H., Dröge, W., & Krammer, P. H.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1994-10-01
- Volume
- 127
- Issue
- 1
- Pages
- 15-20
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2150882718
- Cited by
- 429
- References
- 32
- FWCI
- 15.93
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Cell nucleus and DNA fragmentation are not required for apoptosis. https://app.cochat.ai/papers/10.1083/jcb.127.1.15
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- Schulze-Osthoff, K., Walczak, H., Dröge, W., & Krammer, P. H. (1994). Cell nucleus and DNA fragmentation are not required for apoptosis. The Journal of cell biology. https://doi.org/10.1083/jcb.127.1.15
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
