MUC1 (CD227): a multi-tasked molecule

Apostolopoulos, Vasso; Stojanovska, Lily; Gargosky, Sharron E.

doi:10.1007/s00018-015-2014-z

Cited by 138Glycosylation and Glycoproteins ResearchProteoglycans and glycosaminoglycans researchCell Adhesion Molecules Research

MUC1 (CD227): a multi-tasked molecule

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Apostolopoulos, Vasso, Stojanovska, Lily, Gargosky, Sharron E.·2015·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-015-2014-zPMC PMC11113675

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Abstract

Mucin 1 (MUC1 [CD227]) is a high-molecular weight (>400 kDa), type I membrane-tethered glycoprotein that is expressed on epithelial cells and extends far above the glycocalyx. MUC1 is overexpressed and aberrantly glycosylated in adenocarcinomas and in hematological malignancies. As a result, MUC1 has been a target for tumor immunotherapeutic studies in mice and in humans. MUC1 has been shown to have anti-adhesive and immunosuppressive properties, protects against infections, and is involved in the oncogenic process as well as in cell signaling. In addition, MUC1 plays a key role in the reproductive tract, in the immune system (affecting dendritic cells, monocytes, T cells, and B cells), and in chronic inflammatory diseases. Evidence for all of these roles for MUC1 is discussed herein and demonstrates that MUC1 is truly a multitasked molecule.

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MUC1 is overexpressed on some adenocarcinoma cells and is an important tumor surface marker, especially for breast cancer.
“MUC1 is a mucin glycoprotein overexpressed on some adenocarcinoma cells and is considered an important tumor surface marker, especially breast cancer. It has been used as a potential target for the treatment of breast cancer.250,251”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [250]

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Authors: Apostolopoulos, V., Stojanovska, L., & Gargosky, S. E.
Affiliations: Victoria University (AU)
Corresponding author: Apostolopoulos, Vasso
ORCID: Apostolopoulos, Vasso
Stojanovska, Lily
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2015-08-21
Volume: 72
Issue: 23
Pages: 4475-4500
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-015-2014-z
PMC: PMC11113675
OpenAlex: W1199355021
Cited by: 138
References: 241
Citations by year: 2026: 13 · 2025: 18 · 2024: 18 · 2023: 11 · 2022: 9 · 2021: 12 · 2020: 15 · 2019: 10 · 2018: 16 · 2017: 9 · 2016: 6
FWCI: 1.00
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Victoria University Research Repository (Victoria University) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords: MUC1, mucin 1, aberrant glycosylation, cancer immunotherapy, immunosuppression, infection control, carcinogenesis, signal transduction, reproductive tract, dendritic cells, monocytes, T cells, B cells, chronic inflammatory diseases
MeSH terms: Amino Acid Sequence, Animals, Cell Communication, Epithelial Cells, Female, Gene Expression Regulation, Humans, Immunotherapy, Leukocytes, Male, Molecular Sequence Data, Pregnancy, Alternative Splicing, Mucin-1, Protein Isoforms, Mice, Host-Pathogen Interactions

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MUC1 (CD227): a multi-tasked molecule

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