The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis.
Open accessAbstract
Among the many target genes of the transcription factor NF-kappaB are p53 and c-myc, both of which are involved in apoptosis. This prompted us to investigate the role of NF-kappaB in this process. We report that NF-kappaB is potently activated upon serum starvation, a condition leading to apoptosis in 293 cells. Similar to Bcl-2, a transdominant-negative mutant of the NF-kappaB p65 subunit partially inhibited apoptosis, indicating a direct involvement of the transcription factor in induction of cell death. As expected, the p65 mutant suppresses kappaB-dependent gene expression. Surprisingly, transiently or stably overexpressed Bcl-2 had the same effect. The transcription inhibitory activity of the two proteins correlated with their cell death protective potential. Like Bcl-2, the related protein Bcl-xL but not Bcl-xS was able to suppress kB-dependent transcription. Bcl-2 inhibited NF-kappaB activity by an unusual mechanism. It did not prevent the release of IkappaB in the cytoplasm but down-modulated the transactivating potential of nuclear p65. These data show that NF-kappaB can participate in apoptosis. We suggest that at least part of the anti-apoptotic potential of Bcl-2 may be explained from a hitherto undiscovered activity of Bcl-2 in controlling nuclear gene expression.
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Cites
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Self-citationBcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
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Cited by
Control of apoptosis by Rel/NF-κB transcription factors
Barkett, M., & Gilmore, T. D. (1999) · Oncogene · doi:10.1038/sj.onc.1203238 · Cited by 1,204
The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal
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Self-citationTo be, or not to be: NF-κB is the answer – role of Rel/NF-κB in the regulation of apoptosis
Kucharczak, J., Simmons, M. J., Fan, Y., & Gélinas, C. (2003) · Oncogene · doi:10.1038/sj.onc.1207230 · Cited by 769
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Long Term Lithium Treatment Suppresses p53 and Bax Expression but Increases Bcl-2 Expression
Chen, R.-W., & Chuang, D.-M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6039 · Cited by 469
Metadata
- Authors
- Grimm, S., Bauer, M. K., Baeuerle, P. A., & Schulze-Osthoff, K.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1996-07-01
- Volume
- 134
- Issue
- 1
- Pages
- 13-23
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1973060929
- Cited by
- 354
- References
- 86
- FWCI
- 16.82
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis. https://app.cochat.ai/papers/10.1083/jcb.134.1.13
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- Grimm, S., Bauer, M. K., Baeuerle, P. A., & Schulze-Osthoff, K. (1996). Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis. The Journal of cell biology. https://doi.org/10.1083/jcb.134.1.13
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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