The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Signal sequences specify the targeting route to the endoplasmic reticulum membrane.
Open accessAbstract
In the yeast Saccharomyces cerevisiae, only a subset of preproteins that are translocated across the ER membrane require the function of the signal recognition particle (SRP), suggesting that an alternative, SRP-independent pathway must exist (Hann, B.C., and P. Walter. 1991. Cell. 67:131-144). We have established that the two targeting pathways function in parallel. Mutant alleles of SEC62 and SEC63 were isolated that specifically impaired the translocation of SRP-independent preproteins in vivo and in vitro, whereas SRP-dependent preproteins were unaffected. Based on this analysis, preproteins fall into three distinct classes: SRP dependent, SRP independent, and those that can use both pathways. Pathway specificity is conferred by the hydrophobic core of signal sequences. Our studies show a previously unrecognized diversity in ER-directed signal sequences, that carry structural information that serves to identify the route taken.
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Cites
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TnphoA: a transposon probe for protein export signals.
Manoil, C., & Beckwith, J. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.23.8129 · Cited by 1,013
Signal Sequence Recognition and Protein Targeting to the Endoplasmic Reticulum Membrane
Walter, P., & Johnson, A. E. (1994) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.10.110194.000511 · Cited by 821
Self-citationGORLICH, D. (1993) · Cell · doi:10.1016/0092-8674(93)90483-7 · Cited by 674
Hydrophobicity scales and computational techniques for detecting amphipathic structures in proteins
Cornette, J. L., Cease, K. B., Margalit, H., Spouge, J. L., Berzofsky, J. A., & DeLisi, C. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90189-6 · Cited by 641
PROTEIN TRANSPORT ACROSS THE EUKARYOTIC ENDOPLASMIC RETICULUM AND BACTERIAL INNER MEMBRANES
Rapoport, T. A., Jungnickel, B., & Kutay, U. (1996) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.65.070196.001415 · Cited by 561
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Cited by
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
Rapoport, T. A. (2007) · Nature · doi:10.1038/nature06384 · Cited by 977
A comprehensive review of signal peptides: Structure, roles, and applications
Owji, H., Nezafat, N., Negahdaripour, M., Hajiebrahimi, A., & Ghasemi, Y. (2018) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2018.06.003 · Cited by 523
Paetzel, M., Karla, A., Strynadka, N. C. J., & Dalbey, R. E. (2002) · Chemical Reviews · doi:10.1021/cr010166y · Cited by 440
PROTEIN TRANSLOCATION BY THE SEC61/SECY CHANNEL
Osborne, A. R., Rapoport, T. A., & van den Berg, B. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.012704.133214 · Cited by 391
Secretory Protein Biogenesis and Traffic in the Early Secretory Pathway
Barlowe, C. K., & Miller, E. A. (2013) · Genetics · doi:10.1534/genetics.112.142810 · Cited by 330
Metadata
- Authors
- Ng, D. T., Brown, J. D., & Walter, P.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1996-07-15
- Volume
- 134
- Issue
- 2
- Pages
- 269-278
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2169597956
- Cited by
- 472
- References
- 38
- FWCI
- 7.45
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
